| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongjie Zhang, Zhixiong Hong, Zehua Jiang, Wei Hu, Jiashao Hu, Rusen Zh. miR-29b-3p Affects the Hypertrophy of Ligamentum Flavum in Lumbar Spinal Stenosis and its Mechanism. Biochemical genetics. 2024-04-16. PMID:38625592. |
to explore the effect of mir-29b-3p on fibrosis and hypertrophy of ligamentum flavum (lf) in lumbar spinal stenosis (lss) and its underlying mechanism. |
2024-04-16 |
2024-04-18 |
human |
| Hongjie Zhang, Zhixiong Hong, Zehua Jiang, Wei Hu, Jiashao Hu, Rusen Zh. miR-29b-3p Affects the Hypertrophy of Ligamentum Flavum in Lumbar Spinal Stenosis and its Mechanism. Biochemical genetics. 2024-04-16. PMID:38625592. |
upregulation of mir-29b-3p expression may play a role in improving lf fibrosis and hypertrophy in lss by inhibiting p16 expression and suppressing the activation of the tgf-β/smad signaling pathway. |
2024-04-16 |
2024-04-18 |
human |
| Nagy Mekhail, Krista Topalsky, Erin Templeton, Sherif Armanyous, Nicholas Prayson, Carl Olde, Shrif Costand. Patient and physician radiation exposure during minimally invasive lumbar decompression: A prospective assessment of X-ray exposure risks. Pain practice : the official journal of World Institute of Pain. 2023-12-09. PMID:38069541. |
minimally invasive lumbar decompression (mild®) is becoming a popular procedure for treating lumbar spinal stenosis (lss) secondary to hypertrophic ligamentum flavum (lf). |
2023-12-09 |
2023-12-17 |
Not clear |
| Kazuya Maeda, Kazuki Sugimoto, Masayoshi Tasaki, Takuya Taniwaki, Takahiro Arima, Yuto Shibata, Makoto Tateyama, Tatsuki Karasugi, Takanao Sueyoshi, Tetsuro Masuda, Yusuke Uehara, Takuya Tokunaga, Satoshi Hisanaga, Masaki Yugami, Ryuji Yonemitsu, Katsumasa Ideo, Kozo Matsushita, Yuko Fukuma, Masaru Uragami, Junki Kawakami, Naoto Yoshimura, Kosei Takata, Masaki Shimada, Shuntaro Tanimura, Hideto Matsunaga, Yuki Kai, Shu Takata, Ryuta Kubo, Rui Tajiri, Fuka Homma, Xiao Tian, Mitsuharu Ueda, Takayuki Nakamura, Takeshi Miyamot. Transthyretin amyloid deposition in ligamentum flavum (LF) is significantly correlated with LF and epidural fat hypertrophy in patients with lumbar spinal stenosis. Scientific reports. vol 13. issue 1. 2023-11-17. PMID:37973808. |
ligamentum flavum (lf) hypertrophy and spinal epidural lipomatosis in the spinal canal are known to contribute to stenosis of the spinal canal: however, detailed mechanisms underlying lss are still not fully understood. |
2023-11-17 |
2023-11-20 |
Not clear |
| Kevin G Burt, Dan C Viola, Lauren E Lisiewski, Joseph M Lombardi, Louis F Amorosa, Nadeen O Chahin. An in vivo model of ligamentum flavum hypertrophy from early-stage inflammation to fibrosis. JOR spine. vol 6. issue 3. 2023-10-02. PMID:37780823. |
multi-joint disease pathologies in the lumbar spine, including ligamentum flavum (lf) hypertrophy and intervertebral disc (ivd) bulging or herniation contribute to lumbar spinal stenosis (lss), a highly prevalent condition characterized by symptomatic narrowing of the spinal canal. |
2023-10-02 |
2023-10-07 |
rat |
| Yifei Gu, Jinquan Hu, Chen Wang, Min Qi, Yu Chen, Wenchao Yu, Zhanchao Wang, Xinwei Wang, Wen Yua. Smurf1 Facilitates Oxidative Stress and Fibrosis of Ligamentum Flavum by Promoting Nrf2 Ubiquitination and Degradation. Mediators of inflammation. vol 2023. 2023-04-24. PMID:37091902. |
lumbar spinal stenosis (lss), which can lead to irreversible neurologic damage and functional disability, is characterized by hypertrophy and fibrosis in the ligamentum flavum (lf). |
2023-04-24 |
2023-08-14 |
Not clear |
| Richard A Wawrose, Anthony A Oyekan, Yunting Melissa Tang, Stephen R Chen, Joseph Chen, Brandon K Couch, Dong Wang, Peter G Alexander, Gwendolyn A Sowa, Nam V Vo, Joon Y Le. MicroRNA-29a: a novel target for non-operative management of symptomatic lumbar spinal stenosis. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. 2023-04-12. PMID:37046075. |
the cause of lss is multifactorial; however, a significant contributor is ligamentum flavum hypertrophy (lfh) which causes mechanical compression of the cauda equina or nerve roots. |
2023-04-12 |
2023-08-14 |
Not clear |
| Kai Zhang, Xin Wang, Li-Ting Zeng, Xiao Yang, Xiao-Fei Cheng, Hai-Jun Tian, Chen Chen, Xiao-Jiang Sun, Chang-Qing Zhao, Hui Ma, Jie Zha. Circular RNA PDK1 targets miR-4731-5p to enhance TNXB expression in ligamentum flavum hypertrophy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 5. 2023-04-04. PMID:37014317. |
hypertrophic ligamentum flavum (lf) is a main factor responsible for lumbar spinal stenosis (lss); however, the exact mechanisms of the pathogenesis of these processes remain unknown. |
2023-04-04 |
2023-08-14 |
Not clear |
| Kai Zhang, Xin Wang, Li-Ting Zeng, Xiao Yang, Xiao-Fei Cheng, Hai-Jun Tian, Chen Chen, Xiao-Jiang Sun, Chang-Qing Zhao, Hui Ma, Jie Zha. Circular RNA PDK1 targets miR-4731-5p to enhance TNXB expression in ligamentum flavum hypertrophy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 37. issue 5. 2023-04-04. PMID:37014317. |
the circpdk1-mir-4731-tnxb pathway may be proposed as a regulatory axis in lf hypertrophy, which might shed light on in-depth research of lss, as well as providing a novel therapeutic target for lf hypertrophy-induced lss. |
2023-04-04 |
2023-08-14 |
Not clear |
| Yu-Chia Hsu, Hao-Chun Chuang, Kun-Ling Tsai, Ting-Yuan Tu, Yan-Jye Shyong, Cheng-Hsiang Kuo, Yuan-Fu Liu, Shu-Shien Shih, Cheng-Li Li. Administration of N-Acetylcysteine to Regress the Fibrogenic and Proinflammatory Effects of Oxidative Stress in Hypertrophic Ligamentum Flavum Cells. Oxidative medicine and cellular longevity. vol 2022. 2022-11-07. PMID:36338342. |
ligamentum flavum hypertrophy (lfh) is a major cause of lumbar spinal stenosis (lss). |
2022-11-07 |
2023-08-14 |
Not clear |
| Nina He, Wenbin Qi, Yongli Zhao, Xiaojun Wan. Relationship between Severity of Lumbar Spinal Stenosis and Ligamentum Flavum Hypertrophy and Serum Inflammatory Factors. Computational and mathematical methods in medicine. vol 2022. 2022-10-24. PMID:36277021. |
this study is aimed at investigating the correlation between lumbar spinal stenosis (lss) severity, ligamentum flavum hypertrophy, and the upregulation of inflammatory markers. |
2022-10-24 |
2023-08-14 |
Not clear |
| Yang Duan, Jianjun Li, Sujun Qiu, Songjia Ni, Yanlin Ca. TCF7/SNAI2/miR-4306 feedback loop promotes hypertrophy of ligamentum flavum. Journal of translational medicine. vol 20. issue 1. 2022-10-12. PMID:36224570. |
hypertrophy of ligamentum flavum (hlf) is the mainly cause of lumbar spinal stenosis (lss), but the precise mechanism of hlf formation has not been fully elucidated. |
2022-10-12 |
2023-08-14 |
Not clear |
| Jin Young Hong, Hyunseong Kim, Junseon Lee, Wan-Jin Jeon, Yoon Jae Lee, In-Hyuk H. Oxidative medicine and cellular longevity. vol 2022. 2022-09-26. PMID:36160714. |
ligamentum flavum hypertrophy is a major lss cause that may result from oxidative stress caused by degenerative cascades, including imbalanced iron homeostasis that leads to excessive reactive oxygen species production. |
2022-09-26 |
2023-08-14 |
Not clear |
| Christina C Westhoff, Christian-Dominik Peterlein, Hanna Daniel, Juergen R Paletta, Roland Moll, Annette Ramaswamy, Stefan Lakemeie. Expression of Estrogen Receptor Alpha and Evaluation of Histological Degeneration Scores in Fibroblasts of Hypertrophied Ligamentum Flavum: A Qualitative Study. Biomolecules. vol 11. issue 12. 2021-12-24. PMID:34944396. |
the most common spinal disorder in elderly is lumbar spinal stenosis (lss), resulting partly from ligamentum flavum (lf) hypertrophy. |
2021-12-24 |
2023-08-13 |
Not clear |
| Hamidullah Salimi, Akinobu Suzuki, Hasibullah Habibi, Kumi Orita, Yusuke Hori, Akito Yabu, Hidetomi Terai, Koji Tamai, Hiroaki Nakamur. Biglycan expression and its function in human ligamentum flavum. Scientific reports. vol 11. issue 1. 2021-11-22. PMID:33649499. |
hypertrophy of the ligamentum flavum (lf) is a major cause of lumbar spinal stenosis (lss), and the pathology involves disruption of elastic fibers, fibrosis with increased cellularity and collagens, and/or calcification. |
2021-11-22 |
2023-08-13 |
human |
| Hamidullah Salimi, Akinobu Suzuki, Hasibullah Habibi, Kumi Orita, Yusuke Hori, Akito Yabu, Hidetomi Terai, Koji Tamai, Hiroaki Nakamur. Biglycan expression and its function in human ligamentum flavum. Scientific reports. vol 11. issue 1. 2021-11-22. PMID:33649499. |
to investigate the involvement of bgn in the pathomechanism of human ligamentum hypertrophy, first we confirmed increased expression of bgn by immunohistochemistry in the extracellular matrix of hypertrophied lf of lss patients compared to lf without hypertrophy. |
2021-11-22 |
2023-08-13 |
human |
| Fumio Hayashi, Masatoshi Morimoto, Kosaku Higashino, Yuichiro Goda, Nori Sato, Fumitake Tezuka, Kazuta Yamashita, Koichi Sairy. Myofibroblasts are increased in the dorsal layer of the hypertrophic ligamentum flavum in lumbar spinal canal stenosis. The spine journal : official journal of the North American Spine Society. 2021-11-14. PMID:34775048. |
hypertrophy of the ligamentum flavum (lf) is a major contributor to the development of lumbar spinal canal stenosis (lss). |
2021-11-14 |
2023-08-13 |
Not clear |
| Zhongxiu Chen, Chunmei Li, Yajiao Li, Li Rao, Xiaoling Zhang, Dan Long, Chen L. Layer-specific strain echocardiography may reflect regional myocardial impairment in patients with hypertrophic cardiomyopathy. Cardiovascular ultrasound. vol 19. issue 1. 2021-10-25. PMID:33658038. |
our study aimed to determine whether layer-specific strain (lss) could reflect regional myocardial impairment in patients with hypertrophic cardiomyopathy (hcm). |
2021-10-25 |
2023-08-13 |
Not clear |
| Hasibullah Habibi, Akinobu Suzuki, Kazunori Hayashi, Hamidullah Salimi, Hidetomi Terai, Yusuke Hori, Koji Tamai, Kumi Orita, Shoichiro Ohyama, Akito Yabu, Mohammad Hasib Maruf, Hiroaki Nakamur. Expression and function of FGF9 in the hypertrophied ligamentum flavum of lumbar spinal stenosis patients. The spine journal : official journal of the North American Spine Society. vol 21. issue 6. 2021-07-28. PMID:33577925. |
ligamentum flavum (lf) hypertrophy plays a dominant role in lumbar spinal stenosis (lss). |
2021-07-28 |
2023-08-13 |
human |
| Rebecca Bradley, Aditaya Kumar, Chris Barret. The glasgow lumbar spinal stenosis scale: an individualised measurement formula for the radiological assessment of lumbar spinal stenosis. British journal of neurosurgery. 2021-07-28. PMID:34319198. |
lss can be described qualitatively with reference to facet and ligamentous hypertrophy, lack of perineural or intraforaminal fat, and reduced csf around the cauda equina. |
2021-07-28 |
2023-08-13 |
Not clear |