| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| Sivasundaram Karnan, Ichiro Hanamura, Akinobu Ota, Lam Quang Vu, Kaori Uchino, Tomohiro Horio, Satsuki Murakami, Shohei Mizuno, Md Lutfur Rahman, Md Wahiduzzaman, Muhammad Nazmul Hasan, Mrityunjoy Biswas, Toshinori Hyodo, Hideaki Ito, Atsushi Suzuki, Hiroyuki Konishi, Shinobu Tsuzuki, Yoshitaka Hosokawa, Akiyoshi Takam. ARK5 enhances cell survival associated with mitochondrial morphological dynamics from fusion to fission in human multiple myeloma cells. Cell death discovery. vol 10. issue 1. 2024-01-28. PMID:38282096. |
furthermore, ark5-ko cells demonstrated a lower phosphorylated dynamin-related protein 1 at serine 616, higher protein expression of mitofusin-1 (mfn1) and mfn2, optic atrophy 1 with a lower level of atp, and higher levels of lactate and reactive oxygen species than ark5-wt cells. |
2024-01-28 |
2024-01-31 |
human |
| Weilin Liu, Fan Li, Dongwei Guo, Congyuan Du, Song Zhao, Juan Li, Zhe Yan, Jun Ha. Schisandrin B Alleviates Renal Tubular Cell Epithelial-Mesenchymal Transition and Mitochondrial Dysfunction by Kielin/Chordin-like Protein Upregulation via Akt Pathway Inactivation and Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase Pathway Activation in Diabetic Kidney Disease. Molecules (Basel, Switzerland). vol 28. issue 23. 2023-12-09. PMID:38067580. |
moreover, under high glucose conditions, sch b effectively increased mitochondrial membrane potential, lowered ros production, and increased the atp content in hk2 cells, accompanied by the upregulation of pgc-1α, tfam, mfn1, and mfn2. |
2023-12-09 |
2023-12-17 |
mouse |
| Shengnan Wang, Haiyang Zhao, Suxian Lin, Yang Lv, Yue Lin, Yinai Liu, Renyi Peng, Huanzhi Ji. New therapeutic directions in type II diabetes and its complications: mitochondrial dynamics. Frontiers in endocrinology. vol 14. 2023-09-06. PMID:37670891. |
the former is coordinated by mitofusin-1 (mfn1), mitofusin-2 (mfn2), and optic atrophy 1 (opa1), and the latter is mediated by dynamin related protein 1 (drp1), mitochondrial fission 1 (fis1) and mitochondrial fission factor (mff). |
2023-09-06 |
2023-10-07 |
Not clear |
| Hamed Alizadeh Pahlavan. Exercise therapy to prevent and treat Alzheimer's disease. Frontiers in aging neuroscience. vol 15. 2023-08-21. PMID:37600508. |
in the hippocampus, exercise training decreases mitochondrial fragmentation, drp1, and fis1, improving opa1, mfn1, mfn2, and mitochondrial morphology. |
2023-08-21 |
2023-09-07 |
human |
| Yu Xia, Shanshan Li, Xixi Wang, Bing Zhao, Shasha Chen, Qihang Jiang, Shiwen Xu, Shu L. Astilbin targeted Sirt1 to inhibit acetylation of Nrf2 to alleviate grass carp hepatocyte apoptosis caused by PCB126-induced mitochondrial kinetic and metabolism dysfunctions. Fish & shellfish immunology. 2023-08-19. PMID:37597642. |
our findings revealed that pcb126 exposure resulted in a decrease in expression levels of sirt1, factors related to mitochondrial fusion (opa1, mfn1, and mfn2), antioxidant (cat, sod1, and sod2), energy metabolism (pkm2, idh, and sdh) and anti-apoptosis (bcl-2), and an increase in expression levels of nrf2 acetylation, mitochondrial fission (drp1), factors that promote apoptosis (cytc, bax, cas9, and cas3) in l8824 cells. |
2023-08-19 |
2023-09-07 |
cat |
| Pierce Colpman, Asish Dasgupta, Stephen L Arche. The Role of Mitochondrial Dynamics and Mitotic Fission in Regulating the Cell Cycle in Cancer and Pulmonary Arterial Hypertension: Cells. vol 12. issue 14. 2023-07-29. PMID:37508561. |
mitochondrial fusion is regulated by the large gtpases mitofusin-1 (mfn1) and mitofusin-2 (mfn2), which fuse the omm, and optic atrophy 1 (opa-1), which fuses the inner mitochondrial membrane. |
2023-07-29 |
2023-08-14 |
Not clear |
| Minfang Guo, Huiyu Zhang, Peijun Zhang, Jingwen Yu, Tao Meng, Suyao Li, Lijuan Song, Zhi Chai, Jiezhong Yu, Cungen M. [Knock-down of ROCK2 gene improves cognitive function and reduces neuronal apoptosis in AD mice by promoting mitochondrial fusion and inhibiting its division]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 8. 2023-07-29. PMID:37515336. |
western blot analysis was used to detect the expression rock2, cleaved-caspase-3 (c-caspase-3), b-cell lymphoma 2 (bcl2), bcl2-related protein x (bax), p-drp1, mitochondrial fission 1 (fis1), optic atrophy 1 (opa1), mfn1 and mfn2. |
2023-07-29 |
2023-08-14 |
mouse |
| Minfang Guo, Huiyu Zhang, Peijun Zhang, Jingwen Yu, Tao Meng, Suyao Li, Lijuan Song, Zhi Chai, Jiezhong Yu, Cungen M. [Knock-down of ROCK2 gene improves cognitive function and reduces neuronal apoptosis in AD mice by promoting mitochondrial fusion and inhibiting its division]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 8. 2023-07-29. PMID:37515336. |
results compared with ad group mice, the expression of rock2 in shrock2 group mice was significantly reduced; the cognitive function was significantly improved with the number of neurons in the hippocampal ca3 and dg areas increasing, and nissl bodies were deeply stained; the expression of c-caspase-3 and bax was decreased, while the expression of bcl2 was increased; the expression of mitochondrial division related proteins p-drp1 and fis1 were decreased, while the expression of mitochondrial fusion-related proteins opa1, mfn1 and mfn2 were increased. |
2023-07-29 |
2023-08-14 |
mouse |
| Wei Han, Muhan Li, Mengyi Yang, Si Chen, Yuanyuan Lu, Tiantian Tang, Rui Wang, Chenguang Zhang, Kemin Q. Dietary Folic Acid Supplementation Inhibits HighFat DietInduced Body Weight Gain through Gut Microbiota-Associated Branched-Chain Amino Acids and Mitochondria in Mice. Journal of nutritional science and vitaminology. vol 69. issue 2. 2023-04-30. PMID:37121720. |
in cv mice, the hd-induced increases in body weight and plasma bcaa concentrations, downregulated expression of genes related to bcaa catabolism (bcat2, bckdha, or ppm1k), mitochondrial biogenesis (pgc-1α, cox1, nd1 or nd6), fusion (mfn1, mfn2 or opa1) and mitophagy (pink1 or park2), and upregulated expression of the fission-associated gene drp1 in epididymal fat were reversely corrected with fshd feeding. |
2023-04-30 |
2023-08-14 |
mouse |
| Minxin Wang, Jinyu Xu, Zhengbo Zhao, Lichao Gong, Yu Su, Zhichao Fang, Pengfei Chen, Yifan Liu, Lianshuang Zhang, Feibo X. Triphenyl phosphate induced apoptosis of mice testicular Leydig cells and TM3 cells through ROS-mediated mitochondrial fusion inhibition. Ecotoxicology and environmental safety. vol 256. 2023-04-07. PMID:37027944. |
moreover, tphp disrupted mitochondrial ultrastructure of testicular leydig cells and tm3 cells, reduced healthy mitochondria content and depressed mitochondrial membrane potential of tm3 cells, as well as inhibited mitochondrial fusion proteins mitofusin 1 (mfn1), mitofusin 2 (mfn2), and optic atrophy 1 (opa1) expression, without effect on mitochondrial fission proteins dynamin-related protein 1 (drp1) and fission 1 (fis1) in testicular tissue and/or tm3 cells. |
2023-04-07 |
2023-08-14 |
mouse |
| Yi Xia, Xu Zhang, Peng An, Junjie Luo, Yongting Lu. Mitochondrial Homeostasis in VSMCs as a Central Hub in Vascular Remodeling. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834896. |
guanosine triphosphate-hydrolyzing enzymes, including mitofusin 1 (mfn1), mitofusin 2 (mfn2), optic atrophy protein 1 (opa1) and dynamin-related protein 1 (drp1), are crucial for mitochondrial fusion and fission. |
2023-02-25 |
2023-08-14 |
Not clear |
| Xiaxia Xiong, Weiping Xiong, Linyuan Li, Juan DU, Daozhuang Wang, Xu Wan. [Down-regulation of miR-29a inhibits mitochondrial fusion and fission in rat H9c2 cardiomyocytes induced by oxygen and glucose deprivation/reoxygenation]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 11. 2022-11-03. PMID:36328430. |
western blot analysis was employed to test the levels of bcl2-associated x protein (bax), bcl2 antagonist/killer (bak), caspase-9, mitochondrial fission protein 1(fis1), mitofusin 1 (mfn1), mfn2, optic atrophy 1(opa1), phosphoryerated extracellular signal-regulated kinase (p-erk) and phosphoryerated dynamin related protein-1(p-drp1). |
2022-11-03 |
2023-08-14 |
rat |
| Lepeng Gao, Chang Zhang, Sicong Yu, Shuang Liu, Guoxia Wang, Hainan Lan, Xin Zheng, Suo L. Environmental pollution glycine ameliorates MBP-induced meiotic abnormalities and apoptosis by regulating mitochondrial-endoplasmic reticulum interactions in porcine oocytes. Environmental pollution (Barking, Essex : 1987). 2022-07-15. PMID:35839969. |
the results showed that the addition of gly significantly decreased the rate of mbp-induced spindle abnormalities, decreased the frequency of mbp-induced mitochondria-associated er membrane (mam) interactions, and downregulated the protein and gene expression of the linkage molecules mitofusin 1 (mfn1) and mitofusin 2 (mfn2) in the mam. |
2022-07-15 |
2023-08-14 |
human |
| Jianguo Lin, Jinlong Duan, Qingqing Wang, Siyu Xu, Simin Zhou, Kuiwu Ya. Mitochondrial Dynamics and Mitophagy in Cardiometabolic Disease. Frontiers in cardiovascular medicine. vol 9. 2022-07-05. PMID:35783853. |
this paper reviewed the mechanisms of mitochondrial dynamics and mitophagy (focus on mfn1, mfn2, opa1, drp1, and pink1 proteins) and their roles in diabetic cardiomyopathy, myocardial infarction, cardiac hypertrophy, heart failure, atherosclerosis, and obesity. |
2022-07-05 |
2023-08-14 |
Not clear |
| Eleni Georgiadou, Charanya Muralidharan, Michelle Martinez, Pauline Chabosseau, Elina Akalestou, Alejandra Tomas, Fiona Yong Su Wern, Theodoros Stylianides, Asger Wretlind, Cristina Legido-Quigley, Ben Jones, Livia Lopez Noriega, Yanwen Xu, Guoqiang Gu, Nour Alsabeeh, Céline Cruciani-Guglielmacci, Christophe Magnan, Mark Ibberson, Isabelle Leclerc, Yusuf Ali, Scott A Soleimanpour, Amelia K Linnemann, Tristan A Rodriguez, Guy A Rutte. Mitofusins Mfn1 and Mfn2 are Required to Preserve Glucose- But Not Incretin-Stimulated Beta Cell Connectivity and Insulin Secretion. Diabetes. 2022-04-26. PMID:35472764. |
mitofusins mfn1 and mfn2 are required to preserve glucose- but not incretin-stimulated beta cell connectivity and insulin secretion. |
2022-04-26 |
2023-08-13 |
mouse |
| Teresa Vezza, Pedro Díaz-Pozo, Francisco Canet, Aranzazu M de Marañón, Zaida Abad-Jiménez, Celia García-Gargallo, Ildefonso Roldan, Eva Solá, Celia Bañuls, Sandra López-Domènech, Milagros Rocha, Víctor M Vícto. The Role of Mitochondrial Dynamic Dysfunction in Age-Associated Type 2 Diabetes. The world journal of men's health. 2022-01-12. PMID:35021300. |
the molecular mechanisms underlying these processes include fusion proteins (mitofusin 1 [mfn1], mitofusin 2 [mfn2], and optic atrophy 1 [opa1]) and fission mediators (mitochondrial fission 1 [fis1] and dynamin-related protein 1 [drp1]), which interact with each other to ensure mitochondrial quality control. |
2022-01-12 |
2023-08-13 |
Not clear |
| Fei-Fei Wu, Kun-Long Zhang, Zheng-Mei Wang, Yi Yang, Shao-Hua Li, Jia-Qi Wang, Jin Ma, Yan-Ling Yang, Hai-Feng Zhang, Ya-Yun Wan. Benefit of a single simulated hypobaric hypoxia in healthy mice performance and analysis of mitochondria-related gene changes. Scientific reports. vol 11. issue 1. 2021-11-15. PMID:33627689. |
third, the effects of shh on 8 mitochondria-related genes of drp1, mfn1, mfn2, opa1, tfam, sgk1, ucp2 and ucp4, were assessed in cerebellum, hippocampus and gastrocnemius muscles. |
2021-11-15 |
2023-08-13 |
mouse |
| Azam Kia, Mona Nadi, Vahideh Hajhasan, Jafar Salimia. Alterations in Mitochondrial and Inflammasome Homeostasis by 2-Chloroethyl Ethyl Sulfide and Their Mitigation by Curcumin: An in Vitro Study. Iranian journal of allergy, asthma, and immunology. vol 20. issue 5. 2021-10-20. PMID:34664820. |
after the treatment of pulmonary epithelial cell line (a549) by 2-chloroethyl ethyl sulfide (cees) (2500 mm) for 48h, the transcriptional activity of mitochondrial fission and fusion genes such as dynamin-related protein 1 (drp1), mitochondrial fission 1 protein (fis1), mitofusin-1 (mfn1), mitofusin-2 (mfn2), and dominant optic atrophy (opa1) and inflammasome pathway genes including absent in melanoma 2 (aim2), nlr family containing protein 3 (nlrp3), and apoptosis-associated speck-like protein containing a caspase recruitment domain (asc) was measured. |
2021-10-20 |
2023-08-13 |
Not clear |
| Weidong Zhang, Hideyuki Sakoda, Yuki Nakazato, Md Nurul Islam, François Pattou, Julie Kerr-Conte, Masamitsu Nakazat. Neuromedin U uses Gαi2 and Gαo to suppress glucose-stimulated Ca2+ signaling and insulin secretion in pancreatic β cells. PloS one. vol 16. issue 4. 2021-09-24. PMID:33857254. |
knockdown of gαi2 and gαo in β cells counteracted nmu-induced suppression of insulin secretion and gene alterations related to mitochondrial fusion (mfn1, mfn2), fission (fis1, drp1), mitophagy (pink1, park2), mitochondrial dynamics (pgc-1α, nrf1, and tfam), er stress (chop, atp2a3, ryr2, and itpr2), intracellular atp level, and mitochondrial membrane potential. |
2021-09-24 |
2023-08-13 |
mouse |