| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| Yuxuan Song, Shuang Ren, Xingmei Chen, Xuhong Li, Lin Chen, Shijie Zhao, Yue Zhang, Xiangchun Shen, Yan Che. Inhibition of MFN1 restores tamoxifen-induced apoptosis in resistant cells by disrupting aberrant mitochondrial fusion dynamics. Cancer letters. 2024-04-07. PMID:38583647. |
the interaction of mfn1 and cristae-shaping protein optic atrophy 1 (opa1) and opa1 oligomerization were reduced due to augmented opa1 proteolytic cleavage, and their apoptosis-promoting function was reduced due to cristae remodeling. |
2024-04-07 |
2024-04-10 |
Not clear |
| Xibing Yu, Hexiang Jiang, Jindou Li, Jiaxin Ding, Kainan Chen, Zhuang Ding, Xiaohong X. NDV inhibited IFN-β secretion through impeding CHCHD10-mediated mitochondrial fusion to promote viral proliferation. Veterinary microbiology. vol 290. 2024-01-11. PMID:38211361. |
the proteins involved in mitochondrial fusion, namely mitofusin 1 (mfn1) and optic atrophy 1 (opa1) are associated with interferon-beta (ifn-β) secretion during ndv infection. |
2024-01-11 |
2024-01-14 |
human |
| Li Wang, Rafael Rivas, Angelo Wilson, Yu Min Park, Shannon Walls, Tianzheng Yu, Alexandra C Mille. Dose-Dependent Effects of Radiation on Mitochondrial Morphology and Clonogenic Cell Survival in Human Microvascular Endothelial Cells. Cells. vol 13. issue 1. 2024-01-11. PMID:38201243. |
the study further revealed that low doses induced mitochondrial elongation, likely via an increase in mitochondrial fusion protein 1 (mfn1), while high doses caused mitochondrial fragmentation via a decrease in optic atrophy protein 1 (opa1). |
2024-01-11 |
2024-01-13 |
human |
| Jie Chen, Xufang Gao, Chengyou Zheng, Chen Zhang, Peimao Li, Kaiwu He, Gongping Liu, Xinfeng Huang, Jianjun Liu, Yongmei Xie, Xifei Yan. Low-dose Cu exposure enhanced α-synuclein accumulation associates with mitochondrial impairments in mice model of Parkinson's disease. Toxicology letters. 2023-09-17. PMID:37717680. |
these changes were associated with increased mitochondrial splitting protein (drp1), decreased mitochondrial fusion protein (opa1, mfn1), abnormalities in mitochondrial autophagy protein (lc3bii/i, p62), decreased dopamine neuron (th) expression, increased α-synuclein expression, inflammatory factors (il-6, il-1β, and tnf-α) release and microglia (iba1) activation. |
2023-09-17 |
2023-10-07 |
mouse |
| Shengnan Wang, Haiyang Zhao, Suxian Lin, Yang Lv, Yue Lin, Yinai Liu, Renyi Peng, Huanzhi Ji. New therapeutic directions in type II diabetes and its complications: mitochondrial dynamics. Frontiers in endocrinology. vol 14. 2023-09-06. PMID:37670891. |
the former is coordinated by mitofusin-1 (mfn1), mitofusin-2 (mfn2), and optic atrophy 1 (opa1), and the latter is mediated by dynamin related protein 1 (drp1), mitochondrial fission 1 (fis1) and mitochondrial fission factor (mff). |
2023-09-06 |
2023-10-07 |
Not clear |
| Hamed Alizadeh Pahlavan. Exercise therapy to prevent and treat Alzheimer's disease. Frontiers in aging neuroscience. vol 15. 2023-08-21. PMID:37600508. |
in the hippocampus, exercise training decreases mitochondrial fragmentation, drp1, and fis1, improving opa1, mfn1, mfn2, and mitochondrial morphology. |
2023-08-21 |
2023-09-07 |
human |
| Yu Xia, Shanshan Li, Xixi Wang, Bing Zhao, Shasha Chen, Qihang Jiang, Shiwen Xu, Shu L. Astilbin targeted Sirt1 to inhibit acetylation of Nrf2 to alleviate grass carp hepatocyte apoptosis caused by PCB126-induced mitochondrial kinetic and metabolism dysfunctions. Fish & shellfish immunology. 2023-08-19. PMID:37597642. |
our findings revealed that pcb126 exposure resulted in a decrease in expression levels of sirt1, factors related to mitochondrial fusion (opa1, mfn1, and mfn2), antioxidant (cat, sod1, and sod2), energy metabolism (pkm2, idh, and sdh) and anti-apoptosis (bcl-2), and an increase in expression levels of nrf2 acetylation, mitochondrial fission (drp1), factors that promote apoptosis (cytc, bax, cas9, and cas3) in l8824 cells. |
2023-08-19 |
2023-09-07 |
cat |
| Minfang Guo, Huiyu Zhang, Peijun Zhang, Jingwen Yu, Tao Meng, Suyao Li, Lijuan Song, Zhi Chai, Jiezhong Yu, Cungen M. [Knock-down of ROCK2 gene improves cognitive function and reduces neuronal apoptosis in AD mice by promoting mitochondrial fusion and inhibiting its division]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 8. 2023-07-29. PMID:37515336. |
western blot analysis was used to detect the expression rock2, cleaved-caspase-3 (c-caspase-3), b-cell lymphoma 2 (bcl2), bcl2-related protein x (bax), p-drp1, mitochondrial fission 1 (fis1), optic atrophy 1 (opa1), mfn1 and mfn2. |
2023-07-29 |
2023-08-14 |
mouse |
| Minfang Guo, Huiyu Zhang, Peijun Zhang, Jingwen Yu, Tao Meng, Suyao Li, Lijuan Song, Zhi Chai, Jiezhong Yu, Cungen M. [Knock-down of ROCK2 gene improves cognitive function and reduces neuronal apoptosis in AD mice by promoting mitochondrial fusion and inhibiting its division]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 8. 2023-07-29. PMID:37515336. |
results compared with ad group mice, the expression of rock2 in shrock2 group mice was significantly reduced; the cognitive function was significantly improved with the number of neurons in the hippocampal ca3 and dg areas increasing, and nissl bodies were deeply stained; the expression of c-caspase-3 and bax was decreased, while the expression of bcl2 was increased; the expression of mitochondrial division related proteins p-drp1 and fis1 were decreased, while the expression of mitochondrial fusion-related proteins opa1, mfn1 and mfn2 were increased. |
2023-07-29 |
2023-08-14 |
mouse |
| Wei Han, Muhan Li, Mengyi Yang, Si Chen, Yuanyuan Lu, Tiantian Tang, Rui Wang, Chenguang Zhang, Kemin Q. Dietary Folic Acid Supplementation Inhibits HighFat DietInduced Body Weight Gain through Gut Microbiota-Associated Branched-Chain Amino Acids and Mitochondria in Mice. Journal of nutritional science and vitaminology. vol 69. issue 2. 2023-04-30. PMID:37121720. |
in cv mice, the hd-induced increases in body weight and plasma bcaa concentrations, downregulated expression of genes related to bcaa catabolism (bcat2, bckdha, or ppm1k), mitochondrial biogenesis (pgc-1α, cox1, nd1 or nd6), fusion (mfn1, mfn2 or opa1) and mitophagy (pink1 or park2), and upregulated expression of the fission-associated gene drp1 in epididymal fat were reversely corrected with fshd feeding. |
2023-04-30 |
2023-08-14 |
mouse |
| Minxin Wang, Jinyu Xu, Zhengbo Zhao, Lichao Gong, Yu Su, Zhichao Fang, Pengfei Chen, Yifan Liu, Lianshuang Zhang, Feibo X. Triphenyl phosphate induced apoptosis of mice testicular Leydig cells and TM3 cells through ROS-mediated mitochondrial fusion inhibition. Ecotoxicology and environmental safety. vol 256. 2023-04-07. PMID:37027944. |
moreover, tphp disrupted mitochondrial ultrastructure of testicular leydig cells and tm3 cells, reduced healthy mitochondria content and depressed mitochondrial membrane potential of tm3 cells, as well as inhibited mitochondrial fusion proteins mitofusin 1 (mfn1), mitofusin 2 (mfn2), and optic atrophy 1 (opa1) expression, without effect on mitochondrial fission proteins dynamin-related protein 1 (drp1) and fission 1 (fis1) in testicular tissue and/or tm3 cells. |
2023-04-07 |
2023-08-14 |
mouse |
| Yi Xia, Xu Zhang, Peng An, Junjie Luo, Yongting Lu. Mitochondrial Homeostasis in VSMCs as a Central Hub in Vascular Remodeling. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834896. |
guanosine triphosphate-hydrolyzing enzymes, including mitofusin 1 (mfn1), mitofusin 2 (mfn2), optic atrophy protein 1 (opa1) and dynamin-related protein 1 (drp1), are crucial for mitochondrial fusion and fission. |
2023-02-25 |
2023-08-14 |
Not clear |
| Xuena Zhang, Mingying Li, Yun Yue, Ying Zhang, Anshi W. Luteoloside prevents sevoflurane-induced cognitive dysfunction in aged rats via maintaining mitochondrial function and dynamics in hippocampal neurons. Neuroscience. 2023-02-10. PMID:36764603. |
mechanistically, luteoloside maintained mitochondrial function and dynamics, as evidenced by the restored adenosine triphosphate (atp) production and mitochondrial membrane potential as well as the upregulated levels of mitochondrial fission (optic atrophy protein 1 (opa1) and mitofusin1 (mfn1)) and downregulated mitochondrial fusion (mitochondrial fission 1 (fisl) and dynamin-related protein 1 (drp1)) factors. |
2023-02-10 |
2023-08-14 |
rat |
| Xiaxia Xiong, Weiping Xiong, Linyuan Li, Juan DU, Daozhuang Wang, Xu Wan. [Down-regulation of miR-29a inhibits mitochondrial fusion and fission in rat H9c2 cardiomyocytes induced by oxygen and glucose deprivation/reoxygenation]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 38. issue 11. 2022-11-03. PMID:36328430. |
western blot analysis was employed to test the levels of bcl2-associated x protein (bax), bcl2 antagonist/killer (bak), caspase-9, mitochondrial fission protein 1(fis1), mitofusin 1 (mfn1), mfn2, optic atrophy 1(opa1), phosphoryerated extracellular signal-regulated kinase (p-erk) and phosphoryerated dynamin related protein-1(p-drp1). |
2022-11-03 |
2023-08-14 |
rat |
| Dandan Liu, Jiande Li, Xiaoming Rong, Jie Li, Ying Peng, Qingyu She. Cdk5 Promotes Mitochondrial Fission via Drp1 Phosphorylation at S616 in Chronic Ethanol Exposure-Induced Cognitive Impairment. Molecular neurobiology. 2022-09-09. PMID:36083519. |
in this study, we found that chronic exposure to ethanol caused abnormal mitochondrial fission/fusion and morphology by activating the mitochondrial fission protein dynamin-related protein 1 (drp1) and upregulating drp1 receptors, such as fission protein 1 (fis1), mitochondrial dynamics protein of 49 kda (mid49), and mitochondrial fission factor (mff), combined with decreasing optic atrophy 1 (opa1) and mitochondrial fusion protein mitofusin 1 (mfn1) levels. |
2022-09-09 |
2023-08-14 |
mouse |
| Jianguo Lin, Jinlong Duan, Qingqing Wang, Siyu Xu, Simin Zhou, Kuiwu Ya. Mitochondrial Dynamics and Mitophagy in Cardiometabolic Disease. Frontiers in cardiovascular medicine. vol 9. 2022-07-05. PMID:35783853. |
this paper reviewed the mechanisms of mitochondrial dynamics and mitophagy (focus on mfn1, mfn2, opa1, drp1, and pink1 proteins) and their roles in diabetic cardiomyopathy, myocardial infarction, cardiac hypertrophy, heart failure, atherosclerosis, and obesity. |
2022-07-05 |
2023-08-14 |
Not clear |
| Nancy P Gómez-Crisóstomo, Selva Rivas-Arancibia, Erika Rodríguez-Martínez, Erick N De la Cruz-Hernández, Corazón de María Márquez Álvarez, Pablo Alexis Estrada Caraveo, Noemí Gelista Herrera, Marlen Valdés-Fuentes, Eduardo Martínez-Abundi. Chronic exposition to ozone induces cardiac antioxidant response and overexpression of either mitochondrial fision protein DRP1 and hipertrophyc-related proteins. Journal of bioenergetics and biomembranes. 2022-03-29. PMID:35347511. |
oxidative stress was evaluated by tbars and protein nitrosylation in addition to superoxide dismutase 1 (sod1) and catalase levels; the apoptosis related-proteins caspase 3, caspase 9, bax, bcl-2, and the mitochondrial dynamic-associated proteins fis1, drp1, opa1, and mfn1 were quantified by western blot among the cardiac hypertrophy indicator alpha-actin (cardiac actin). |
2022-03-29 |
2023-08-13 |
rat |
| Xiao-Yu Song, Peng-Cheng Liu, Wei-Wei Liu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejim. Protective effects of silibinin against ethanol- or acetaldehyde-caused damage in liver cell lines involve the repression of mitochondrial fission. Toxicology in vitro : an international journal published in association with BIBRA. 2022-02-14. PMID:35158046. |
silibinin reduced the expression of mitochondrial fission-associated proteins, dynamin-related protein 1 (drp1), but increased mitochondrial fusion-associated proteins, optic atrophy 1 (opa1) and mitofusin 1 (mfn1). |
2022-02-14 |
2023-08-13 |
human |
| Teresa Vezza, Pedro Díaz-Pozo, Francisco Canet, Aranzazu M de Marañón, Zaida Abad-Jiménez, Celia García-Gargallo, Ildefonso Roldan, Eva Solá, Celia Bañuls, Sandra López-Domènech, Milagros Rocha, Víctor M Vícto. The Role of Mitochondrial Dynamic Dysfunction in Age-Associated Type 2 Diabetes. The world journal of men's health. 2022-01-12. PMID:35021300. |
the molecular mechanisms underlying these processes include fusion proteins (mitofusin 1 [mfn1], mitofusin 2 [mfn2], and optic atrophy 1 [opa1]) and fission mediators (mitochondrial fission 1 [fis1] and dynamin-related protein 1 [drp1]), which interact with each other to ensure mitochondrial quality control. |
2022-01-12 |
2023-08-13 |
Not clear |