| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| Azam Kia, Mona Nadi, Vahideh Hajhasan, Jafar Salimia. Alterations in Mitochondrial and Inflammasome Homeostasis by 2-Chloroethyl Ethyl Sulfide and Their Mitigation by Curcumin: An in Vitro Study. Iranian journal of allergy, asthma, and immunology. vol 20. issue 5. 2021-10-20. PMID:34664820. |
after the treatment of pulmonary epithelial cell line (a549) by 2-chloroethyl ethyl sulfide (cees) (2500 mm) for 48h, the transcriptional activity of mitochondrial fission and fusion genes such as dynamin-related protein 1 (drp1), mitochondrial fission 1 protein (fis1), mitofusin-1 (mfn1), mitofusin-2 (mfn2), and dominant optic atrophy (opa1) and inflammasome pathway genes including absent in melanoma 2 (aim2), nlr family containing protein 3 (nlrp3), and apoptosis-associated speck-like protein containing a caspase recruitment domain (asc) was measured. |
2021-10-20 |
2023-08-13 |
Not clear |
| Shunrong Zhang, Fei Feng, Jingting Dai, Jia Li, Xiangye Bu, Xiaojie Xi. Recombinant High-Mobility Group Box 1 (rHMGB1) Promotes NRF2-Independent Mitochondrial Fusion through CXCR4/PSMB5-Mediated Drp1 Degradation in Endothelial Cells. Oxidative medicine and cellular longevity. vol 2021. 2021-08-17. PMID:34394840. |
the expression of dynamin-related protein 1 (drp1), mitofusin 1 (mfn1), mitofusin 2 (mfn2), optic atrophy 1 (opa1), phosphatase and tensin homolog- (pten-) induced kinase 1 (pink1), nod-like receptor 3 (nlrp3), caspase 1, cleaved caspase 1, 20s proteasome subunit beta 5 (psmb5), and antioxidative master nuclear factor e2-related factor 2 (nrf2) and the concentration of interleukin 1 |
2021-08-17 |
2023-08-13 |
human |
| Cui-Cui Zhao, Juan Xu, Qiu-Meng Xie, Hai-Yun Zhang, Guang-He Fei, Hui-Mei W. Abscisic acid suppresses the activation of NLRP3 inflammasome and oxidative stress in murine allergic airway inflammation. Phytotherapy research : PTR. vol 35. issue 6. 2021-06-29. PMID:33570219. |
the results showed that aba effectively stunted the development of airway inflammation, and concordantly downregulated ova-induced activation of nlrp3 inflammasome, suppressed oxidative stress and decreased the expression of mitochondrial fusion/fission markers including optic atrophy 1 (opa1), mitofusion 2 (mfn2), dynamin-related protein 1 (drp1) and fission 1 (fis1). |
2021-06-29 |
2023-08-13 |
Not clear |