| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
western blot was used to detect apoptosis (bcl-2, bax, and cleaved-caspase-3); synapses (postsynaptic densifying protein 95, syn1, and synaptophysin); mitochondria (drp1, opa1, mfn1, and mfn2); er (grp78, atf6, chop, and caspase-12); nlrp3 inflammasome (nlrp3, asc, and caspase-1); inflammatory cytokines (il-18, il-1β, and tnf-α); akt (p-akt); and mitogen-activated protein kinase (mapk) pathway (p-erk, p-p38, and p-jnk) related protein expression. |
2024-04-16 |
2024-04-18 |
rat |
| Ying He, Ruicheng Li, Yuxi Yu, Chusheng Huang, Zhiran Xu, Tianbao Wang, Chen Ming, Hongri Huang, Zhongquan Q. Human neural stem cells promote mitochondrial genesis to alleviate neuronal damage in MPTP-induced cynomolgus monkey models. Neurochemistry international. 2024-02-28. PMID:38417589. |
furthermore, nscs elevated proliferator-activated receptor gamma coactivator-1 alpha(pgc-1a), mitofusin 2(mfn2), and optic atrophy 1(opa1) expression, three genes mediating mitochondrial biogenesis, in the sn and striatum of pd monkeys. |
2024-02-28 |
2024-03-02 |
human |
| Chenfei Li, Qi Liu, Qing Chang, Meiqin Xie, Jiali Weng, Xiaohui Wang, Mengnan Li, Jiani Chen, Yan Huang, Xiaohua Yang, Kai Wang, Na Zhang, Kian Fan Chung, Ian M Adcock, Hai Zhang, Feng L. Role of mitochondrial fusion proteins MFN2 and OPA1 on lung cellular senescence in chronic obstructive pulmonary disease. Respiratory research. vol 24. issue 1. 2023-12-19. PMID:38110986. |
this study examined mitochondrial dynamics, mitophagy and lung cellular senescence in copd patients and investigated the effects of modulation of mitochondrial fusion [mitofusin2 (mfn2) and optic atrophy 1 (opa1)] on cs extract (cse)-induced lung cellular senescence. |
2023-12-19 |
2023-12-21 |
Not clear |
| A Reum Han, Tae Kwon Moon, Im Kyeung Kang, Dae Bong Yu, Yechan Kim, Cheolhwan Byon, Sujeong Park, Hae Lin Kim, Kyoung Jin Lee, Heuiran Lee, Ha-Na Woo, Seong Who Ki. Research progress on hydrogel-based drug therapy in melanoma immunotherapy. BMB reports. 2023-12-06. PMID:38053296. |
furthermore, data-driven analyses involving human subjects within the hippocampus and brain revealed significant reductions of opa1 and mfn2 in the alzheimer's disease (ad) patients. |
2023-12-06 |
2023-12-10 |
human |
| Wanling Zhang, Haiyan Yang, Zhengyun Liu, Shengyu Wang, Tianyang Chen, Hong Song, Yunbin Xu, Fajin Li, Guo Luo, Huan Wan. Enterovirus 71 leads to abnormal mitochondrial dynamics in human neuroblastoma SK-N-SH cells. Virus research. 2023-11-10. PMID:37949375. |
furthermore, we identified the reduction in the expression of dynamin-related protein 1 (drp1) and optic atrophy protein 1 (opa1) and the increased expression of mitofusion 2 (mfn2) upon ev71 infection. |
2023-11-10 |
2023-11-20 |
human |
| Jing Zhao, Hua-Qing Yu, Feng-Qin Ge, Man-Ru Zhang, Yu-Chen Song, Dan-Dan Guo, Qi-Hang Li, Hua Zhu, Peng-Zhou Han. 7,8,3'-Trihydroxyflavone prevents doxorubicin-induced cardiotoxicity and mitochondrial dysfunction via activating Akt signaling pathway in H9c2 cells. Cellular signalling. 2023-10-14. PMID:37838311. |
the protein levels of key mitochondria-related factors such as adenosine monophosphate-activated protein kinase (ampk), mitofusin 2 (mfn2), dynamin-related protein 1 (drp1), and optic atrophy protein 1 (opa1) were examined. |
2023-10-14 |
2023-11-08 |
Not clear |
| B Haridevamuthu, Raghul Murugan, Boopathi Seenivasan, Ramu Meenatchi, Raman Pachaiappan, Bader O Almutairi, Selvaraj Arokiyaraj, Kathiravan M K, Jesu Arockiara. Synthetic azo-dye, Tartrazine induces neurodevelopmental toxicity via mitochondria-mediated apoptosis in zebrafish embryos. Journal of hazardous materials. vol 461. 2023-09-23. PMID:37741213. |
gene expression analyses revealed broad disruptions in genes associated with antioxidant defense (sod1, cat, and gstp1), mitochondrial dysfunction (mfn2, opa1, and fis1),evoked inflammatory response (nfkb, tnfa, and il1b), apoptosis activation (bcl2, bax, and p53), and neural development (bdnf, mbp, and syn2a). |
2023-09-23 |
2023-10-07 |
human |
| Shengnan Wang, Haiyang Zhao, Suxian Lin, Yang Lv, Yue Lin, Yinai Liu, Renyi Peng, Huanzhi Ji. New therapeutic directions in type II diabetes and its complications: mitochondrial dynamics. Frontiers in endocrinology. vol 14. 2023-09-06. PMID:37670891. |
the former is coordinated by mitofusin-1 (mfn1), mitofusin-2 (mfn2), and optic atrophy 1 (opa1), and the latter is mediated by dynamin related protein 1 (drp1), mitochondrial fission 1 (fis1) and mitochondrial fission factor (mff). |
2023-09-06 |
2023-10-07 |
Not clear |
| Hamed Alizadeh Pahlavan. Exercise therapy to prevent and treat Alzheimer's disease. Frontiers in aging neuroscience. vol 15. 2023-08-21. PMID:37600508. |
in the hippocampus, exercise training decreases mitochondrial fragmentation, drp1, and fis1, improving opa1, mfn1, mfn2, and mitochondrial morphology. |
2023-08-21 |
2023-09-07 |
human |
| Yu Xia, Shanshan Li, Xixi Wang, Bing Zhao, Shasha Chen, Qihang Jiang, Shiwen Xu, Shu L. Astilbin targeted Sirt1 to inhibit acetylation of Nrf2 to alleviate grass carp hepatocyte apoptosis caused by PCB126-induced mitochondrial kinetic and metabolism dysfunctions. Fish & shellfish immunology. 2023-08-19. PMID:37597642. |
our findings revealed that pcb126 exposure resulted in a decrease in expression levels of sirt1, factors related to mitochondrial fusion (opa1, mfn1, and mfn2), antioxidant (cat, sod1, and sod2), energy metabolism (pkm2, idh, and sdh) and anti-apoptosis (bcl-2), and an increase in expression levels of nrf2 acetylation, mitochondrial fission (drp1), factors that promote apoptosis (cytc, bax, cas9, and cas3) in l8824 cells. |
2023-08-19 |
2023-09-07 |
cat |
| Peng Zheng, Wenjing Ma, Yilu Gu, Hengfang Wu, Zhiping Bian, Nannan Liu, Di Yang, Xiangjian Che. High-fat diet causes mitochondrial damage and downregulation of mitofusin-2 and optic atrophy-1 in multiple organs. Journal of clinical biochemistry and nutrition. vol 73. issue 1. 2023-08-03. PMID:37534099. |
these results indicated that high-fat feeding caused pathological changes in multiple organs, accompanied by mitochondrial ultrastructural damage, and mfn2 and opa1 downregulation. |
2023-08-03 |
2023-08-14 |
mouse |
| Minfang Guo, Huiyu Zhang, Peijun Zhang, Jingwen Yu, Tao Meng, Suyao Li, Lijuan Song, Zhi Chai, Jiezhong Yu, Cungen M. [Knock-down of ROCK2 gene improves cognitive function and reduces neuronal apoptosis in AD mice by promoting mitochondrial fusion and inhibiting its division]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 8. 2023-07-29. PMID:37515336. |
western blot analysis was used to detect the expression rock2, cleaved-caspase-3 (c-caspase-3), b-cell lymphoma 2 (bcl2), bcl2-related protein x (bax), p-drp1, mitochondrial fission 1 (fis1), optic atrophy 1 (opa1), mfn1 and mfn2. |
2023-07-29 |
2023-08-14 |
mouse |
| Minfang Guo, Huiyu Zhang, Peijun Zhang, Jingwen Yu, Tao Meng, Suyao Li, Lijuan Song, Zhi Chai, Jiezhong Yu, Cungen M. [Knock-down of ROCK2 gene improves cognitive function and reduces neuronal apoptosis in AD mice by promoting mitochondrial fusion and inhibiting its division]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 39. issue 8. 2023-07-29. PMID:37515336. |
results compared with ad group mice, the expression of rock2 in shrock2 group mice was significantly reduced; the cognitive function was significantly improved with the number of neurons in the hippocampal ca3 and dg areas increasing, and nissl bodies were deeply stained; the expression of c-caspase-3 and bax was decreased, while the expression of bcl2 was increased; the expression of mitochondrial division related proteins p-drp1 and fis1 were decreased, while the expression of mitochondrial fusion-related proteins opa1, mfn1 and mfn2 were increased. |
2023-07-29 |
2023-08-14 |
mouse |
| Kun Zhang, Tao Wang, Gui-Feng Sun, Jin-Xing Xiao, Li-Ping Jiang, Fang-Fang Tou, Xin-Hui Qu, Xiao-Jian Ha. Metformin protects against retinal ischemia/reperfusion injury through AMPK-mediated mitochondrial fusion. Free radical biology & medicine. 2023-05-30. PMID:37253410. |
compound c and knockdown of mfn2 or opa1 dramatically alleviated the protective effect of metformin against intracellular ros generation, mmp disruption, mitochondrial fission and loss of rgcs in ganglion cell layer-induced by sir or i/r. |
2023-05-30 |
2023-08-14 |
Not clear |
| Wei Han, Muhan Li, Mengyi Yang, Si Chen, Yuanyuan Lu, Tiantian Tang, Rui Wang, Chenguang Zhang, Kemin Q. Dietary Folic Acid Supplementation Inhibits HighFat DietInduced Body Weight Gain through Gut Microbiota-Associated Branched-Chain Amino Acids and Mitochondria in Mice. Journal of nutritional science and vitaminology. vol 69. issue 2. 2023-04-30. PMID:37121720. |
in cv mice, the hd-induced increases in body weight and plasma bcaa concentrations, downregulated expression of genes related to bcaa catabolism (bcat2, bckdha, or ppm1k), mitochondrial biogenesis (pgc-1α, cox1, nd1 or nd6), fusion (mfn1, mfn2 or opa1) and mitophagy (pink1 or park2), and upregulated expression of the fission-associated gene drp1 in epididymal fat were reversely corrected with fshd feeding. |
2023-04-30 |
2023-08-14 |
mouse |
| Minxin Wang, Jinyu Xu, Zhengbo Zhao, Lichao Gong, Yu Su, Zhichao Fang, Pengfei Chen, Yifan Liu, Lianshuang Zhang, Feibo X. Triphenyl phosphate induced apoptosis of mice testicular Leydig cells and TM3 cells through ROS-mediated mitochondrial fusion inhibition. Ecotoxicology and environmental safety. vol 256. 2023-04-07. PMID:37027944. |
moreover, tphp disrupted mitochondrial ultrastructure of testicular leydig cells and tm3 cells, reduced healthy mitochondria content and depressed mitochondrial membrane potential of tm3 cells, as well as inhibited mitochondrial fusion proteins mitofusin 1 (mfn1), mitofusin 2 (mfn2), and optic atrophy 1 (opa1) expression, without effect on mitochondrial fission proteins dynamin-related protein 1 (drp1) and fission 1 (fis1) in testicular tissue and/or tm3 cells. |
2023-04-07 |
2023-08-14 |
mouse |
| Yi Xia, Xu Zhang, Peng An, Junjie Luo, Yongting Lu. Mitochondrial Homeostasis in VSMCs as a Central Hub in Vascular Remodeling. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834896. |
guanosine triphosphate-hydrolyzing enzymes, including mitofusin 1 (mfn1), mitofusin 2 (mfn2), optic atrophy protein 1 (opa1) and dynamin-related protein 1 (drp1), are crucial for mitochondrial fusion and fission. |
2023-02-25 |
2023-08-14 |
Not clear |
| Clement Larrue, Sarah Mouche, Shan Lin, Federico Simonetta, Nastassja K Scheidegger, Laury Poulain, Rudy Birsen, Jean-Emmanuel Sarry, Kimberly Stegmaier, Jerome Tamburin. Mitochondrial fusion is a therapeutic vulnerability of acute myeloid leukemia. Leukemia. 2023-02-04. PMID:36739349. |
genetic depletion of mitofusin 2 (mfn2) or optic atrophy 1 (opa1) or pharmacological inhibition of opa1 (myls22) blocked mitochondrial fusion and had significant anti-leukemic activity, while having limited impact on normal hematopoietic cells ex vivo and in vivo. |
2023-02-04 |
2023-08-14 |
Not clear |
| Lina Jia, Tianwen Ma, Liangyu Lv, Yue Yu, Mingchao Zhao, Hong Chen, Li Ga. Endoplasmic reticulum stress mediated by ROS participates in cadmium exposure-induced MC3T3-E1 cell apoptosis. Ecotoxicology and environmental safety. vol 251. 2023-01-20. PMID:36669278. |
in our study, cd is believed to induce mitochondrial dysfunction and endoplasmic reticulum stress (ers) in a dose-dependent manner, thereby leading to apoptosis, as evident by elevated drp1, fis1, grp78, chop, atf4, p-eif2α, p-perk, bax, cleaved caspase 3 proteins expression and ros levels, and decreased the levels of mfn2, opa1, bcl2, and intracellular collagen i, b-alp, runx2, and bgp genes. |
2023-01-20 |
2023-08-14 |
Not clear |
| Hongyu Li, Joseph C K Leung, Wai Han Yiu, Loretta Y Y Chan, Bin Li, Sarah W Y Lok, Rui Xue, Yixin Zou, Kar Neng Lai, Sydney C W Tan. Tubular β-catenin alleviates mitochondrial dysfunction and cell death in acute kidney injury. Cell death & disease. vol 13. issue 12. 2022-12-20. PMID:36539406. |
in both aki models, tubular β-catenin stabilization in tubcat animals significantly reduced bun/serum creatinine, tubular damage (ngal-positive tubules), apoptosis (tunel-positive cells) and necroptosis (phosphorylation of mlkl and rip3) through activating akt phosphorylation and p53 suppression; enhanced mitochondrial biogenesis (increased pgc-1α and nrf1) and restored mitochondrial mass (increased tim23) to re-establish mitochondrial homeostasis (increased fusion markers opa1, mfn2, and decreased fission protein drp1) through the foxo3/pgc-1α signaling cascade. |
2022-12-20 |
2023-08-14 |
mouse |