| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Simin Zheng, Yunpeng Teng, Hongtao Liu, Jiaxuan He, Shaobo Zhang, Hongfei Xion. Syringaresinol attenuates Tau phosphorylation and ameliorates cognitive dysfunction induced by sevoflurane in aged rats. Journal of neuropathology and experimental neurology. 2024-04-16. PMID:38622895. |
syr exerts neuroprotective effects on sevoflurane-induced cognitive dysfunction by modulating glial activity, apoptotic signaling, and tau phosphorylation through the sirt1 pathway. |
2024-04-16 |
2024-04-18 |
rat |
| Yingjun Zhu, Min Zhang, Jiayu Wang, Qingxiu Wan. Lin28A Reduced Sevoflurane-Induced Nerve Injury and Cognitive Dysfunction by Inhibiting Tau Acetylation and Phosphorylation via Activating SIRT1 in Elderly Rats. Neurotoxicity research. 2022-11-02. PMID:36322362. |
further mechanistic analysis showed that lin28a significantly promoted sirt1 expression, which further reversed sev-induced tau acetylation at lysine 280 and 686 and tau hyperphosphorylation, thereby alleviating nerve injury and cognitive dysfunction in elderly rats. |
2022-11-02 |
2023-08-14 |
rat |
| Yingjun Zhu, Min Zhang, Jiayu Wang, Qingxiu Wan. Lin28A Reduced Sevoflurane-Induced Nerve Injury and Cognitive Dysfunction by Inhibiting Tau Acetylation and Phosphorylation via Activating SIRT1 in Elderly Rats. Neurotoxicity research. 2022-11-02. PMID:36322362. |
lin28a reduced sevoflurane-induced nerve injury and cognitive dysfunction by inhibiting tau acetylation and phosphorylation via activating sirt1 in elderly rats. |
2022-11-02 |
2023-08-14 |
rat |
| Yingjun Zhu, Min Zhang, Jiayu Wang, Qingxiu Wan. Lin28A Reduced Sevoflurane-Induced Nerve Injury and Cognitive Dysfunction by Inhibiting Tau Acetylation and Phosphorylation via Activating SIRT1 in Elderly Rats. Neurotoxicity research. 2022-11-02. PMID:36322362. |
in conclusion, our findings demonstrated that lin28a reduced sevoflurane-induced nerve injury and cognitive dysfunction by inhibiting tau acetylation and phosphorylation via activating sirt1 in elderly rats. |
2022-11-02 |
2023-08-14 |
rat |
| Naihao Shi, Yuwen Lin, Binbin Yan, Xiaowei Jiao, Xiaobao Ding, Yuqing Wu, Chenghua Zho. Hippocampal SIRT1 improves cognitive impairment by deacetylating tau protein in diabetic models. European journal of pharmacology. vol 914. 2021-12-11. PMID:34861210. |
hippocampal sirt1 improves cognitive impairment by deacetylating tau protein in diabetic models. |
2021-12-11 |
2023-08-13 |
rat |
| Naihao Shi, Yuwen Lin, Binbin Yan, Xiaowei Jiao, Xiaobao Ding, Yuqing Wu, Chenghua Zho. Hippocampal SIRT1 improves cognitive impairment by deacetylating tau protein in diabetic models. European journal of pharmacology. vol 914. 2021-12-11. PMID:34861210. |
further study showed that the decreased level of sirt1 may result in the increase of acetylated tau protein in the hippocampus, which may mediate the development of diabetic cognitive impairment. |
2021-12-11 |
2023-08-13 |
rat |
| Jing Yan, Ailin Luo, Rao Sun, Xiaole Tang, Yilin Zhao, Jie Zhang, Biyun Zhou, Hua Zheng, Honghui Yu, Shiyong L. Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery. Oxidative medicine and cellular longevity. vol 2020. 2021-09-02. PMID:33381265. |
in the present study, our findings showed that tau acetylation mediated by sirt1 deficiency resulted in tau hyperphosphorylation in the hippocampus of the aged pocd model and consequently contributed to cognitive impairment. |
2021-09-02 |
2023-08-13 |
rat |
| Jing Yan, Ailin Luo, Rao Sun, Xiaole Tang, Yilin Zhao, Jie Zhang, Biyun Zhou, Hua Zheng, Honghui Yu, Shiyong L. Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery. Oxidative medicine and cellular longevity. vol 2020. 2021-09-02. PMID:33381265. |
what is more, we observed that microglia-derived neuroinflammation resulting from sirt1 inhibition in microglia probably aggravated the tau acetylation in cultured neurons in vitro. |
2021-09-02 |
2023-08-13 |
rat |
| Jing Yan, Ailin Luo, Rao Sun, Xiaole Tang, Yilin Zhao, Jie Zhang, Biyun Zhou, Hua Zheng, Honghui Yu, Shiyong L. Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery. Oxidative medicine and cellular longevity. vol 2020. 2021-09-02. PMID:33381265. |
interestingly, pretreatment with resveratrol almost restored the expression of sirt1, reduced the levels of acetylated tau and hyperphosphorylated tau in the hippocampus, and improved the cognitive performance in the behavioral tests. |
2021-09-02 |
2023-08-13 |
rat |
| Jing Yan, Ailin Luo, Rao Sun, Xiaole Tang, Yilin Zhao, Jie Zhang, Biyun Zhou, Hua Zheng, Honghui Yu, Shiyong L. Resveratrol Mitigates Hippocampal Tau Acetylation and Cognitive Deficit by Activation SIRT1 in Aged Rats following Anesthesia and Surgery. Oxidative medicine and cellular longevity. vol 2020. 2021-09-02. PMID:33381265. |
resveratrol mitigates hippocampal tau acetylation and cognitive deficit by activation sirt1 in aged rats following anesthesia and surgery. |
2021-09-02 |
2023-08-13 |
rat |
| Teresa Diaz-Perdigon, Francisco B Belloch, Ana Ricobaraza, Elghareeb E Elboray, Takayoshi Suzuki, Rosa M Tordera, Elena Puert. Early sirtuin 2 inhibition prevents age-related cognitive decline in a senescence-accelerated mouse model. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 2. 2020-12-28. PMID:31471557. |
samp8 showed hyperphosphorylation of tau protein and decrease levels of sirt1 in the hippocampus, which were not altered by 33i treatment. |
2020-12-28 |
2023-08-13 |
mouse |
| Hye Jin Heo, So Youn Park, Yi Sle Lee, Hwa Kyoung Shin, Ki Whan Hong, Chi Dae Ki. Combination therapy with cilostazol, aripiprazole, and donepezil protects neuronal cells from β-amyloid neurotoxicity through synergistically enhanced SIRT1 expression. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 24. issue 4. 2020-09-28. PMID:32587124. |
in the present study, we found the superior efficacies of donepezil add-on with combinatorial mixture of cilostazol plus aripiprazole in modulation of expression of ad-relevant genes: aβ accumulation, gsk-3β, p300, acetylated tau, phosphorylated-tau levels, and activation of α-secretase/adam 10 through sirt1 activation in the n2a swe cells expressing human app swedish mutation (n2a swe cells). |
2020-09-28 |
2023-08-13 |
human |
| Shuo Qian, Jianlan Gu, Wufei Dai, Nana Jin, Dandan Chu, Qin Huang, Fei Liu, Wei Qia. Sirt1 enhances tau exon 10 inclusion and improves spatial memory of Htau mice. Aging. vol 10. issue 9. 2019-11-08. PMID:30243024. |
sirt1 enhances tau exon 10 inclusion and improves spatial memory of htau mice. |
2019-11-08 |
2023-08-13 |
mouse |
| Shuo Qian, Jianlan Gu, Wufei Dai, Nana Jin, Dandan Chu, Qin Huang, Fei Liu, Wei Qia. Sirt1 enhances tau exon 10 inclusion and improves spatial memory of Htau mice. Aging. vol 10. issue 9. 2019-11-08. PMID:30243024. |
these findings suggest that sirt1 may serve as a new drug target for alzheimer's disease related tauopathies and resveratrol may be used to correct dysregulated tau exon 10 with 3r-tau > 4r-tau. |
2019-11-08 |
2023-08-13 |
mouse |
| Jesus Campagna, Patricia Spilman, Barbara Jagodzinska, Dongsheng Bai, Asa Hatami, Chunni Zhu, Tina Bilousova, Michael Jun, Chris Jean Elias, Johnny Pham, Gregory Cole, Mary Jo LaDu, Michael E Jung, Dale E Bredesen, Varghese Joh. A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model. Scientific reports. vol 8. issue 1. 2019-10-25. PMID:30514854. |
a deficiency in sirt1 level has been recently implicated in increased tau acetylation, a dominant post-translational modification and key pathological event in ad and tauopathies. |
2019-10-25 |
2023-08-13 |
mouse |
| Yue Cao, Zi Yan, Tong Zhou, Guixia Wan. SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models. Journal of diabetes research. vol 2017. 2018-07-23. PMID:29164153. |
in the present study, deacetylation, oxidative stress, mitochondrial dysfunction, inflammation, microrna, and tau phosphorylation are considered in the context of mechanism and significance of sirt1 in learning and memory in diabetic and nondiabetic murine models. |
2018-07-23 |
2023-08-13 |
Not clear |
| Sabrina Salberg, Glenn Yamakawa, Jennaya Christensen, Bryan Kolb, Richelle Mychasiu. Assessment of a nutritional supplement containing resveratrol, prebiotic fiber, and omega-3 fatty acids for the prevention and treatment of mild traumatic brain injury in rats. Neuroscience. vol 365. 2018-06-22. PMID:28988852. |
following the test battery, tissue was collected from the prefrontal cortex (pfc) and primary auditory cortex for golgi-cox analysis of spine density, and for changes in expression of 6 genes (aqp4, gfap, igf1, nfl, sirt1, and tau). |
2018-06-22 |
2023-08-13 |
rat |
| Rubén Corpas, Susana Revilla, Suzanna Ursulet, Marco Castro-Freire, Perla Kaliman, Valérie Petegnief, Lydia Giménez-Llort, Chamsy Sarkis, Mercè Pallàs, Coral Sanfeli. SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic Mechanisms. Molecular neurobiology. vol 54. issue 7. 2018-05-18. PMID:27614878. |
sirt1 induces cell survival and has shown neuroprotection against amyloid and tau pathologies in alzheimer's disease (ad). |
2018-05-18 |
2023-08-13 |
mouse |
| Lai-Ling Du, Jia-Zhao Xie, Xiang-Shu Cheng, Xiao-Hong Li, Fan-Li Kong, Xia Jiang, Zhi-Wei Ma, Jian-Zhi Wang, Chen Chen, Xin-Wen Zho. Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi. Age (Dordrecht, Netherlands). vol 36. issue 2. 2014-11-18. PMID:24142524. |
patients with diabetes in the aging population are at high risk of alzheimer's disease (ad), and reduction of sirtuin 1 (sirt1) activity occurs simultaneously with the accumulation of hyperphosphorylated tau in the ad-affected brain. |
2014-11-18 |
2023-08-12 |
rat |
| Lai-Ling Du, Jia-Zhao Xie, Xiang-Shu Cheng, Xiao-Hong Li, Fan-Li Kong, Xia Jiang, Zhi-Wei Ma, Jian-Zhi Wang, Chen Chen, Xin-Wen Zho. Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi. Age (Dordrecht, Netherlands). vol 36. issue 2. 2014-11-18. PMID:24142524. |
in conclusion, sirt1 protects hippocampus neurons from tau hyperphosphorylation and prevents cognitive impairment induced by icv-stz brain insulin resistance with decreased hippocampus erk1/2 activity. |
2014-11-18 |
2023-08-12 |
rat |