| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohammad S El-Wetidy, Mohamad I Rady, Islam Rady, Hamed Hela. Urolithin A affects cellular migration and modulates matrix metalloproteinase expression in colorectal cancer cells. Cell biochemistry and function. vol 42. issue 3. 2024-04-16. PMID:38622949. |
the western blot analysis investigation revealed that ua inhibits cellular metastasis by lowering the expression levels of matrix metalloproteinases 1 and 2 (mmp1 and mmp2) by more than 43% and 41% (p < .001) in ht29, 28% and 149% (p < .001) in sw480, and 90% and 74% (p < .001) in sw620, respectively, at a 100 µm dosage of ua compared to the control. |
2024-04-16 |
2024-04-18 |
Not clear |
| Hossam El-Sheikh Ali, Kirsten Scoggin, Harutaka Murase, Jamie Norris, Bruno Menarim, Pouya Dini, Barry Bal. Transcriptomic and histochemical analysis reveal the complex regulatory networks in equine Chorioallantois during spontaneous term labor. Biology of reproduction. 2022-08-01. PMID:35913756. |
also, tl was associated with the upregulation of matrix metalloproteinase (mmp1, mmp2, mmp3, and mmp9) with subsequent extracellular matrix degradation and apoptosis, as reflected by upregulation of several apoptosis-related genes (atf3, atf4, fas, fos, and birc3). |
2022-08-01 |
2023-08-14 |
Not clear |
| Shuang Wu, Lijun Song, Meirong Yu, Chao Gong, Lianhua Che. Inhibiting Matrix Metalloproteinases Protects Evoked Electromyography Amplitudes and Muscle Tension in the Orbicularis Oris Muscle in a Rat Model of Facial Nerve Injury. Journal of neuropathology and experimental neurology. 2022-06-03. PMID:35656867. |
we previously demonstrated that mmp1, mmp2, mmp3, mmp7, and mmp9 are overexpressed in facial nerve-innervated orbicularis oris muscle after facial nerve injury in a rat model. |
2022-06-03 |
2023-08-14 |
rat |
| Daiva Bironaitė, Ieva Kažukauskienė, Julius Bogomolovas, Dainius Daunoravičius, Artūras Jakubauskas, Dalius Vitkus, Edvardas Žurauskas, Kęstutis Ručinskas, Siegfried Labeit, Virginija Grabauskien. Molecular Mechanisms behind Persistent Presence of Parvovirus B19 in Human Dilated Myocardium. Advances in experimental medicine and biology. 2022-01-13. PMID:35025080. |
the fibrosis in pvb19-positive embs was also lower compared to the virus-negative ones, while ecm degrading matrix metalloproteinase mmp1 and gelatinase mmp2 were significantly (by twofold) upregulated. |
2022-01-13 |
2023-08-13 |
human |
| Xue-Ming Wang, Xiu-Mei Liu, Yuting Wang, Zhen-Yu Che. Activating transcription factor 3 (ATF3) regulates cell growth, apoptosis, invasion and collagen synthesis in keloid fibroblast through transforming growth factor beta (TGF-beta)/SMAD signaling pathway. Bioengineered. vol 12. issue 1. 2021-11-15. PMID:33315500. |
atf3 also enhanced the invasive potential via upregulating the expression of matrix metalloproteinases (mmp) family members (mmp1, mmp2, mmp9 and mmp13). |
2021-11-15 |
2023-08-13 |
Not clear |
| Han-Soo Kim, Ha Jeong Kim, Mi Ra Lee, Ilkyu Ha. EMMPRIN expression is associated with metastatic progression in osteosarcoma. BMC cancer. vol 21. issue 1. 2021-10-18. PMID:34565336. |
emmprin induces a metastatic phenotype by triggering the production of matrix metalloproteinase proteins (mmps) such as mmp1 and mmp2, and vascular endothelial growth factor (vegf) in cancer cells and the surrounding stromal cells. |
2021-10-18 |
2023-08-13 |
Not clear |
| Hossam El-Sheikh Ali, Kirsten E Scoggin, Rebecca Ruby, Alan Loynachan, Yatta Boakari, Claudia Fernandes, Pouya Dini, Carleigh Elizabeth Fedorka, Shavahn C Loux, Alejandro Esteller-Vico, Barry A Bal. Equine cervical remodeling during placentitis and the prepartum period: a transcriptomic approach. Reproduction (Cambridge, England). vol 161. issue 6. 2021-07-30. PMID:33780349. |
these pathways were accompanied by upregulation of several proteases, including matrix metalloproteinases (mmp1, mmp2, and mmp9), cathepsins (ctsb, ctsc, and ctsd) and a disintegrin and metalloproteinase with thrombospondin type 1 motifs (adamts1, adamts4, and adamts5), which are crucial for degradation of cervical collagens during remodeling. |
2021-07-30 |
2023-08-13 |
Not clear |
| Hossam El-Sheikh Ali, Pouya Dini, Kirsten Scoggin, Shavahn Loux, Carleigh Fedorka, Yatta Boakari, Jamie Norris, Alejandro Esteller-Vico, Theodore Kalbfleisch, Barry Bal. Transcriptomic analysis of equine placenta reveals key regulators and pathways involved in ascending placentitis†. Biology of reproduction. vol 104. issue 3. 2021-07-15. PMID:33345276. |
placentitis was associated with the upregulation of matrix metalloproteinase (mmp1, mmp2, and mmp9) and apoptosis-related genes such as caspases (casp3, casp4, and casp7) in ca. |
2021-07-15 |
2023-08-13 |
Not clear |
| Y Lan, Y Wang, H L. Opsin 3 is a key regulator of ultraviolet A-induced photoageing in human dermal fibroblast cells. The British journal of dermatology. vol 182. issue 5. 2021-05-14. PMID:31380578. |
chronic exposure to ultraviolet (uv) radiation (mainly uva) induces a sustained increase of matrix metalloproteinases (mmps), especially mmp1, mmp2, mmp3 and mmp9 in human skin fibroblasts. |
2021-05-14 |
2023-08-13 |
human |
| Concetta Schiano, Giuditta Benincasa, Monica Franzese, Nunzia Della Mura, Katia Pane, Marco Salvatore, Claudio Napol. Epigenetic-sensitive pathways in personalized therapy of major cardiovascular diseases. Pharmacology & therapeutics. vol 210. 2021-04-21. PMID:32105674. |
at histone level, increased hdac9 was associated with matrix metalloproteinase 1 (mmp1) and mmp2 expression in pro-inflammatory macrophages of human carotid plaque other than to have a positive effect on toll like receptor signaling and innate immunity. |
2021-04-21 |
2023-08-13 |
human |
| Hyeonseok Ko, Gyuwon Huh, Sang Hoon Jung, Hyukjoon Kwon, Youngsic Jeon, Young Nyun Park, Young-Joo Ki. Diospyros kaki leaves inhibit HGF/Met signaling-mediated EMT and stemness features in hepatocellular carcinoma. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 142. 2021-03-29. PMID:32522589. |
the ethanol extract of d. kaki leaves (eedk) markedly suppressed hgf-mediated cell migration and invasion through upregulation of cdh1 and downregulation of snai1, vim, mmp1, mmp2, and mmp9. |
2021-03-29 |
2023-08-13 |
Not clear |
| Zhilei Xie, Tao Fan. The expression and significance of NF-κB, MMP1, and MMP2 in rats with abdominal aortic aneurysm. Cellular and molecular biology (Noisy-le-Grand, France). vol 66. issue 3. 2021-01-22. PMID:32538742. |
this study aimed to investigate the expression and significance of nf-κb, matrix metal protein1 (mmp1), and matrix metal protein2 (mmp2) in rats with abdominal aortic aneurysm (aaa). |
2021-01-22 |
2023-08-13 |
rat |
| Guangjie Zhan, Jun Hu, Benjian Xiao, Xianli Wang, Zixian Yang, Guohua Yang, Lili L. Trillin prevents proliferation and induces apoptosis through inhibiting STAT3 nuclear translocation in hepatoma carcinoma cells. Medical oncology (Northwood, London, England). vol 37. issue 5. 2020-11-12. PMID:32270306. |
trillin could down-regulate bcl-2 and survivin, up-regulate cleaved prap, leading to dramatically apoptosis; trillin could also down-regulate mmp1, mmp2, muci and vegf, which displayed an inhibition effect on hepatocellular tumor cells invasion and development. |
2020-11-12 |
2023-08-13 |
Not clear |
| Tanya Tyagi, May Alarab, Yvonne Leong, Stephen Lye, Oksana Shynlov. Local oestrogen therapy modulates extracellular matrix and immune response in the vaginal tissue of post-menopausal women with severe pelvic organ prolapse. Journal of cellular and molecular medicine. vol 23. issue 4. 2020-07-22. PMID:30772947. |
we found that let application: (a) significantly increased (p < 0.05) gene and protein expression levels of extracellular matrix (ecm) structural proteins, collagen and elastin, as well as the expression of ecm maturation enzyme bmp1; (b) decreased protein expression level of ecm degradation enzymes mmp1, mmp2 and mmp3 accompanied by an increase in their tissue inhibitors, timp1 and timp4; (c) significantly increased (p < 0.05) the gene and protein expression levels of 14 vaginal cytokines involved in leucocyte infiltration, which was confirmed by immunohistochemistry. |
2020-07-22 |
2023-08-13 |
Not clear |
| Simona Slezakova, Petra Borilova Linhartova, Jirina Bartova, Jitka Petanova, Pavel Kuklinek, Antonin Fassmann, Ladislav Dusek, Lydie Izakovicova Holl. Gene variability in matrix metalloproteinases in patients with recurrent aphthous stomatitis. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. vol 49. issue 3. 2020-04-02. PMID:31968135. |
the aim of this study was to investigate polymorphisms located in seven genes coding different types of matrix metalloproteinases (mmps)-collagenases (mmp1, mmp8, and mmp13), gelatinases (mmp2 and mmp9), stromelysin (mmp3), and membrane-type metalloproteinase (mmp16) in patients with ras and healthy controls. |
2020-04-02 |
2023-08-13 |
Not clear |
| Yu Wang, Danyang Zhao, Xiao Wei, Lin Ma, Jing Sheng, Ping L. PEGylated Polyethylenimine Derivative-Mediated Local Delivery of the shSmad3 Inhibits Intimal Thickening after Vascular Injury. BioMed research international. vol 2019. 2020-01-28. PMID:31467913. |
moreover, peg-et 1:1/shsmad3 polyplex treatment significantly inhibited collagen, matrix metalloproteinase 1 (mmp1), mmp2 and mmp9 expression, and upregulated tissue inhibitor of metalloproteinase 1 (timp1) expression both |
2020-01-28 |
2023-08-13 |
Not clear |
| Di Wu, Xin-Ping Wang, Wei Zhan. Sesamolin exerts anti-proliferative and apoptotic effect on human colorectal cancer cells via inhibition of JAK2/STAT3 signaling pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 65. issue 6. 2020-01-08. PMID:31472054. |
the levels of expression of matrix metalloproteinases-1, 2 and 9 (mmp1, mmp2 and mmp9) were determined using real-time quantitative polymerase chain reaction (qrt-pcr). |
2020-01-08 |
2023-08-13 |
human |
| Dharmesh Patel, Sadhana Sharma, Hazel R C Screen, Stephanie J Bryan. Effects of cell adhesion motif, fiber stiffness, and cyclic strain on tenocyte gene expression in a tendon mimetic fiber composite hydrogel. Biochemical and biophysical research communications. vol 499. issue 3. 2018-10-09. PMID:29601813. |
genes associated with tendon (scx and tnmd), collagens (col1a1, col3a1, col11a1), and matrix remodelling (mmp1, mmp2, and timp3) were insensitive to cyclic strain. |
2018-10-09 |
2023-08-13 |
cattle |
| Pengfei Feng, Xiaona Li, Weiyi Chen, Rui He, Xiaojun Wan. [Effects of Tumor Necrosis Factor Alpha on the Expression of Matrix Metalloproteinases and Tissue Inhibitors of Matrix Metalloproteinases in Keratoconus Fibroblasts]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 33. issue 6. 2018-06-18. PMID:29714979. |
the aim of this article is to study the effect of tumor necrosis factor alpha(tnf-α)on the expression of matrix metalloproteinases(mmps)and tissue inhibitors of matrix metalloproteinases(timps)in keratoconus fibroblasts in vitro.normal cornea and keratoconus fibroblasts were extracted using enzyme digestion method and were cultured in the medium containing tnf-α(0,10 and 100ng/ml).the expression of mmps proteins in the supernatant of corneal fibroblasts and the expression of timps in the normal cornea and keratoconus fibroblasts were detected by western blot and real-time quantitative polymerase chain reaction respectively.the active form of mmp1 could be detected in the supernatant of keratoconus fibroblasts and upregulated by tnf-α.tnf-αcould increase the protein expression of mmp2,mmp3,mmp9 in the supernatant of keratoconus fibroblasts and decrease the gene expression of timp1,timp2 in keratoconus fibroblasts.the increased mmps and the decreased timps can increase the degradation of the extracellular matrix.tnf-αmay play an important role in the occurrence and development of keratoconus by regulating the expression of mmps/timps. |
2018-06-18 |
2023-08-13 |
Not clear |
| A S Shadrina, M A Smetanina, K S Sevost'yanova, A I Shevela, E I Seliverstov, E A Zakharova, E N Voronina, E A Ilyukhin, I A Zolotukhin, A I Kirienko, M L Filipenk. Polymorphism of Matrix Metalloproteinases Genes MMP1, MMP2, MMP3, and MMP7 and the Risk of Varicose Veins of Lower Extremities. Bulletin of experimental biology and medicine. vol 163. issue 5. 2018-06-11. PMID:28944430. |
polymorphism of matrix metalloproteinases genes mmp1, mmp2, mmp3, and mmp7 and the risk of varicose veins of lower extremities. |
2018-06-11 |
2023-08-13 |
human |