| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marta Halasa, Ahmed Uosef, Henry V Ubelaker, Arijita Subuddhi, Krupa R Mysore, Jacek Z Kubiak, Rafik M Ghobrial, Jarek Wosik, Malgorzata Klo. Gadolinium retention effect on macrophages - a potential cause of MRI contrast agent Dotarem toxicity. Cell and tissue research. 2024-04-16. PMID:38625373. |
gadolinium retention for 7 days decreased macrophage adhesion and motility and dysregulated the expression of adhesion and fibrotic pathway-related proteins such as notch1 and its ligand jagged1, adhesion/migration-related proteins pak1 and shp1, immune response-related transcription factors smad3 and tcf19, and chemokines cxcl10 and cxcl13, and dysregulated the mrna expression of fibrosis-related genes involved in extracellular matrix (ecm) synthesis, such as col6a1, fibronectin, mmp9, and mmp12. |
2024-04-16 |
2024-04-18 |
Not clear |
| Liang-Hsuan Chien, Jeng-Shyan Deng, Wen-Ping Jiang, Ya-Ni Chou, Jaung-Geng Lin, Guan-Jhong Huan. Evaluation of lung protection of Sanghuangporus sanghuang through TLR4/NF-κB/MAPK, keap1/Nrf2/HO-1, CaMKK/AMPK/Sirt1, and TGF-β/SMAD3 signaling pathways mediating apoptosis and autophagy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-01. PMID:37392658. |
western blot analysis of ss showed that it reduces inflammatory factors (tweak, inos, and cox-2), mapk (jnk, p-erk, and p-38), fibrosis-related molecules (tgf-β, smad3, fibronectin, collagen, α-sma, mmp2, and mmp9), apoptosis (p53, p21, and bax), and autophagy (beclin-1, lc3a/b-i/ii, and p62), and notably increases caspase 3, bcl-2, and antioxidant (catalase, gpx3, and sod-1) levels. |
2023-07-01 |
2023-08-14 |
mouse |
| Xiaohua Dai, Jianbin Shen, Neeraja Priyanka Annam, Hong Jiang, Edi Levi, Charles M Schworer, Gerard Tromp, Anandita Arora, Mary Higgins, Xiao-Fan Wang, Maozhou Yang, Hui J Li, Kezhong Zhang, Helena Kuivaniemi, Li L. SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infiltration in an inflammatory abdominal aortic aneurysm mouse model. Scientific reports. vol 5. 2016-03-24. PMID:25985281. |
the expressions of matrix metalloproteinases including mmp2, mmp9, and mmp12 and infiltration of macrophage/t cells are drastically enhanced in the vascular wall of smad3(-/-) mice. |
2016-03-24 |
2023-08-13 |
mouse |
| Dong Huang, Yingping Liu, Yongjun Huang, Youfu Xie, Kuanhong Shen, Dawei Zhang, Yong Mo. Mechanical compression upregulates MMP9 through SMAD3 but not SMAD2 modulation in hypertrophic scar fibroblasts. Connective tissue research. vol 55. issue 5-6. 2015-07-08. PMID:25166894. |
mechanical compression upregulates mmp9 through smad3 but not smad2 modulation in hypertrophic scar fibroblasts. |
2015-07-08 |
2023-08-13 |
Not clear |
| Eder Marcolin, Beatriz San-Miguel, Daniela Vallejo, Juliana Tieppo, Norma Marroni, Javier González-Gallego, María J Tuñó. Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis. The Journal of nutrition. vol 142. issue 10. 2012-12-03. PMID:22915297. |
feeding the mice the mcd diet also triggered an increase of col1a1, col3a1, plod3, tgfb1, smad3, smad7, pdgfb, ctgf, areg, mmp9, and timp1 mrna levels. |
2012-12-03 |
2023-08-12 |
mouse |