| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Tong, Genhong Yao, Yueqin Chen, Hairong Xie, Xinyu Zheng, Lingyun Sun, Zhenping Huang, Zhenggao Xi. Mesenchymal Stem Cells Regulate Microglial Polarization via Inhibition of the HMGB1/TLR4 Signaling Pathway in Diabetic Retinopathy. Inflammation. 2024-04-16. PMID:38625640. |
overexpression of hmgb1 in microglia reversed the effects of msc treatment, suggesting hmgb1/tlr4 pathway is necessary for mscs' regulatory effects on microglia polarization. |
2024-04-16 |
2024-04-18 |
rat |
| Guoqiang Yang, Xuehui Fan, Maryam Mazhar, Sijin Yang, Houping Xu, Nathupakorn Dechsupa, Li Wan. Mesenchymal Stem Cell Application and Its Therapeutic Mechanisms in Intracerebral Hemorrhage. Frontiers in cellular neuroscience. vol 16. 2022-06-30. PMID:35769327. |
msc transplantation has been proven to improve ich-induced injury, including the damage of nerve cells and oligodendrocytes, the activation of microglia and astrocytes, and the destruction of blood vessels. |
2022-06-30 |
2023-08-14 |
human |
| Ziyu Yu, Yuwen Wen, Nan Jiang, Zhidong Li, Jieying Guan, Yingying Zhang, Caibing Deng, Ling Zhao, Song Guo Zheng, Yingting Zhu, Wenru Su, Yehong Zhu. TNF-α stimulation enhances the neuroprotective effects of gingival MSCs derived exosomes in retinal ischemia-reperfusion injury via the MEG3/miR-21a-5p axis. Biomaterials. vol 284. 2022-04-04. PMID:35378413. |
the present study aimed to elucidate the pathways involving tnf-α-stimulated gingival msc (gmsc)-exosomes (tg-exos), in modulating inflammatory microglia and alleviating apoptosis. |
2022-04-04 |
2023-08-13 |
mouse |
| Ana Isabel Sánchez-Castillo, M Rosario Sepúlveda, José Luis Marín-Teva, Miguel A Cuadros, David Martín-Oliva, Elena González-Rey, Mario Delgado, Veronika E Neubran. Switching Roles: Beneficial Effects of Adipose Tissue-Derived Mesenchymal Stem Cells on Microglia and Their Implication in Neurodegenerative Diseases. Biomolecules. vol 12. issue 2. 2022-02-25. PMID:35204722. |
in this review, we will discuss the application of adipose tissue-derived msc and their conditioned medium, including extracellular vesicles, in neurological disorders, their beneficial effect on microglia and the signaling pathways involved. |
2022-02-25 |
2023-08-13 |
Not clear |
| Henrique C Campos, Deidiane Elisa Ribeiro, Debora Hashiguchi, Deborah Y Hukuda, Christiane Gimenes, Simone A A Romariz, Qing Ye, Yong Tang, Henning Ulrich, Beatriz Monteiro Long. Distinct Effects of the Hippocampal Transplantation of Neural and Mesenchymal Stem Cells in a Transgenic Model of Alzheimer's Disease. Stem cell reviews and reports. 2022-01-08. PMID:34997526. |
therefore, the present study aimed to investigate whether transplantation of nsc or msc into the hippocampus of app/ps1 mice reverses ad-induced pathological alterations, evaluated by the locomotor activity (open field test), short- and long-term memory (object recognition) tests, Αβ plaques (6-e10), microglia distribution (iba-1), m1 (inos) and m2 (arg-1) microglial phenotype frequencies. |
2022-01-08 |
2023-08-13 |
mouse |
| Henrique C Campos, Deidiane Elisa Ribeiro, Debora Hashiguchi, Deborah Y Hukuda, Christiane Gimenes, Simone A A Romariz, Qing Ye, Yong Tang, Henning Ulrich, Beatriz Monteiro Long. Distinct Effects of the Hippocampal Transplantation of Neural and Mesenchymal Stem Cells in a Transgenic Model of Alzheimer's Disease. Stem cell reviews and reports. 2022-01-08. PMID:34997526. |
nsc and msc engraftment reduced the number of Αβ plaques and produced an increase in m2 microglia polarization in the hippocampus of app/ps1 mice, suggesting an anti-inflammatory effect of stem cell transplantation. |
2022-01-08 |
2023-08-13 |
mouse |
| Fatemeh Tahmasebi, Parichehr Pasbakhsh, Shirin Barati, Soheila Madadi, Iraj R Kashan. The effect of microglial ablation and mesenchymal stem cell transplantation on a cuprizone-induced demyelination model. Journal of cellular physiology. vol 236. issue 5. 2021-09-29. PMID:32996165. |
the molecular results showed that msc transplantation significantly decreased the number of microglia through the cx3cl1/cx3cr1 axis. |
2021-09-29 |
2023-08-13 |
mouse |
| Pablo Bonilla, Joaquim Hernandez, Esther Giraldo, Miguel A González-Pérez, Ana Alastrue-Agudo, Hoda Elkhenany, María J Vicent, Xavier Navarro, Michael Edel, Victoria Moreno-Manzan. Human-Induced Neural and Mesenchymal Stem Cell Therapy Combined with a Curcumin Nanoconjugate as a Spinal Cord Injury Treatment. International journal of molecular sciences. vol 22. issue 11. 2021-07-21. PMID:34073117. |
ipsc-nsc + msc transplantation fostered the preservation of motoneurons and myelinated tracts, while pa-c treatment polarized microglia into an anti-inflammatory phenotype. |
2021-07-21 |
2023-08-13 |
human |
| Jan Korbecki, Karolina Bajdak-Rusinek, Patrycja Kupnicka, Patrycja Kapczuk, Donata Simińska, Dariusz Chlubek, Irena Baranowska-Bosiack. The Role of CXCL16 in the Pathogenesis of Cancer and Other Diseases. International journal of molecular sciences. vol 22. issue 7. 2021-07-08. PMID:33800554. |
next, we describe the role of cxcl16 in the tumor microenvironment, including involvement in angiogenesis, and its significance in tumor-associated cells (cancer associated fibroblasts (caf), microglia, tumor-associated macrophages (tam), tumor-associated neutrophils (tan), mesenchymal stem cells (msc), myeloid suppressor cells (mdsc), and regulatory t cells (t |
2021-07-08 |
2023-08-13 |
Not clear |
| Takeo Mukai, Elena Di Martino, Shunichiro Tsuji, Klas Blomgren, Tokiko Nagamura-Inoue, Ulrika Ådé. Umbilical cord-derived mesenchymal stromal cells immunomodulate and restore actin dynamics and phagocytosis of LPS-activated microglia via PI3K/Akt/Rho GTPase pathway. Cell death discovery. vol 7. issue 1. 2021-04-02. PMID:33723246. |
on the other hand, msc co-culture induced bimodal increase in active rac1 and cdc42 levels in lps-activated microglia. |
2021-04-02 |
2023-08-13 |
human |
| Leandro C Teixeira-Pinheiro, Maria F Toledo, Gabriel Nascimento-Dos-Santos, Rosalia Mendez-Otero, Louise A Mesentier-Louro, Marcelo F Santiag. Paracrine signaling of human mesenchymal stem cell modulates retinal microglia population number and phenotype in vitro. Experimental eye research. vol 200. 2021-03-02. PMID:32910940. |
considering the immunomodulating proprieties of msc and the controversial role of microglial contribution on retinal regeneration, we developed an in vitro co-culture model to analyze the effect of msc on retinal microglia population. |
2021-03-02 |
2023-08-13 |
human |
| Kazuki Yokokawa, Naotoshi Iwahara, Shin Hisahara, Miho C Emoto, Taro Saito, Hiromi Suzuki, Tatsuo Manabe, Akihiro Matsumura, Takashi Matsushita, Syuuichirou Suzuki, Jun Kawamata, Hideo Sato-Akaba, Hirotada G Fujii, Shun Shimoham. Transplantation of Mesenchymal Stem Cells Improves Amyloid-β Pathology by Modifying Microglial Function and Suppressing Oxidative Stress. Journal of Alzheimer's disease : JAD. vol 72. issue 3. 2020-11-30. PMID:31640102. |
transplantation of msc also decreased iba1-positive area in the cortex and reduced activated ameboid shaped microglia. |
2020-11-30 |
2023-08-13 |
mouse |
| Kazuki Yokokawa, Naotoshi Iwahara, Shin Hisahara, Miho C Emoto, Taro Saito, Hiromi Suzuki, Tatsuo Manabe, Akihiro Matsumura, Takashi Matsushita, Syuuichirou Suzuki, Jun Kawamata, Hideo Sato-Akaba, Hirotada G Fujii, Shun Shimoham. Transplantation of Mesenchymal Stem Cells Improves Amyloid-β Pathology by Modifying Microglial Function and Suppressing Oxidative Stress. Journal of Alzheimer's disease : JAD. vol 72. issue 3. 2020-11-30. PMID:31640102. |
on the other hand, msc transplantation accelerated accumulation of microglia around aβ deposits and prompted microglial aβ uptake and clearance as shown by higher frequency of aβ-containing microglia. |
2020-11-30 |
2023-08-13 |
mouse |
| Kazuki Yokokawa, Naotoshi Iwahara, Shin Hisahara, Miho C Emoto, Taro Saito, Hiromi Suzuki, Tatsuo Manabe, Akihiro Matsumura, Takashi Matsushita, Syuuichirou Suzuki, Jun Kawamata, Hideo Sato-Akaba, Hirotada G Fujii, Shun Shimoham. Transplantation of Mesenchymal Stem Cells Improves Amyloid-β Pathology by Modifying Microglial Function and Suppressing Oxidative Stress. Journal of Alzheimer's disease : JAD. vol 72. issue 3. 2020-11-30. PMID:31640102. |
msc transplantation also increased cd14-positive microglia in vivo, which play a critical role in aβ uptake. |
2020-11-30 |
2023-08-13 |
mouse |
| Kazuki Yokokawa, Naotoshi Iwahara, Shin Hisahara, Miho C Emoto, Taro Saito, Hiromi Suzuki, Tatsuo Manabe, Akihiro Matsumura, Takashi Matsushita, Syuuichirou Suzuki, Jun Kawamata, Hideo Sato-Akaba, Hirotada G Fujii, Shun Shimoham. Transplantation of Mesenchymal Stem Cells Improves Amyloid-β Pathology by Modifying Microglial Function and Suppressing Oxidative Stress. Journal of Alzheimer's disease : JAD. vol 72. issue 3. 2020-11-30. PMID:31640102. |
to confirm the effects of msc on microglia, we co-cultured the mouse microglial cell line mg6 with msc. |
2020-11-30 |
2023-08-13 |
mouse |
| Lu Zhang, Zhi-Fang Dong, Jie-Yuan Zhan. Immunomodulatory role of mesenchymal stem cells in Alzheimer's disease. Life sciences. vol 246. 2020-03-23. PMID:32035129. |
although numerous strategies have focused on the use of mscs to replace apoptotic or degenerating neurons, recent studies have implied that msc-immunoregulation, which modulates the activity state of microglia or astrocytes and mediates neuroinflammation via several transcription factors (nfs) signaling pathways, may act as a major mechanism for the therapeutic efficacy of msc and be responsible for some of the satisfactory results. |
2020-03-23 |
2023-08-13 |
Not clear |
| Min Young Noh, Su Min Lim, Ki-Wook Oh, Kyung-Ah Cho, Jinseok Park, Kyung-Suk Kim, Su-Jung Lee, Min-Soo Kwon, Seung Hyun Ki. Mesenchymal Stem Cells Modulate the Functional Properties of Microglia via TGF-β Secretion. Stem cells translational medicine. vol 5. issue 11. 2019-11-20. PMID:27400795. |
in this study, we aimed to clarify the role of tgf-β that is involved in msc effectiveness, especially focusing on microglia functional properties that play a pivotal role in neuroinflammation. |
2019-11-20 |
2023-08-13 |
Not clear |
| Hyun Jung Park, Se Hee Oh, Ha Na Kim, Yu Ju Jung, Phil Hyu Le. Mesenchymal stem cells enhance α-synuclein clearance via M2 microglia polarization in experimental and human parkinsonian disorder. Acta neuropathologica. vol 132. issue 5. 2017-09-20. PMID:27497943. |
in α-synuclein-inoculated mice, msc treatment induced m2 microglia polarization decreased α-synuclein levels, and had a prosurvival effect on neurons. |
2017-09-20 |
2023-08-13 |
mouse |
| Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Eva Santermans, Niel Hens, Herman Goossens, Zwi Berneman, Peter Ponsaert. Distinct spatial distribution of microglia and macrophages following mesenchymal stem cell implantation in mouse brain. Immunology and cell biology. vol 92. issue 8. 2015-05-25. PMID:24983456. |
in a model of mesenchymal stem cell (msc) grafting in the cns of immune-competent mice, we previously described that msc grafts become highly surrounded and invaded by iba1(+) myeloid cells (microglia and/or macrophages). |
2015-05-25 |
2023-08-13 |
mouse |
| Debbie Le Blon, Chloé Hoornaert, Jasmijn Daans, Eva Santermans, Niel Hens, Herman Goossens, Zwi Berneman, Peter Ponsaert. Distinct spatial distribution of microglia and macrophages following mesenchymal stem cell implantation in mouse brain. Immunology and cell biology. vol 92. issue 8. 2015-05-25. PMID:24983456. |
analysis of msc-bfp grafts in the cns of these mice confirmed our observation that peripheral monocytes/macrophages invade the msc graft and that resident microglia surround the msc graft site. |
2015-05-25 |
2023-08-13 |
mouse |