| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anfei Liu, Yunting Li, Lifan Li, Kaiju Chen, Meitao Tan, Fei Zou, Xingmei Zhang, Xiaojing Men. Bile acid metabolism is altered in learning and memory impairment induced by chronic lead exposure. Journal of hazardous materials. vol 471. 2024-04-25. PMID:38663295. |
in addition, supplementation with tudca or int-777 significantly alleviated chronic lead exposure-induced learning and memory impairment, primarily through inhibition of the nlrp3 inflammasome in the hippocampus to relieve neuroinflammation. |
2024-04-25 |
2024-04-28 |
mouse |
| Zhu Wang, Bowen Li, Jingrui Yang, Ying Gao, Liu Gao, Qiang Jia, Li Yu, Yunzhi Lin. ML365 ameliorates postoperative cognitive impairment in aged mice by inhibiting NLRP3 inflammasome activation in the hippocampus. Brain research. 2024-04-25. PMID:38663469. |
ml365 ameliorates postoperative cognitive impairment in aged mice by inhibiting nlrp3 inflammasome activation in the hippocampus. |
2024-04-25 |
2024-04-28 |
mouse |
| Zhu Wang, Bowen Li, Jingrui Yang, Ying Gao, Liu Gao, Qiang Jia, Li Yu, Yunzhi Lin. ML365 ameliorates postoperative cognitive impairment in aged mice by inhibiting NLRP3 inflammasome activation in the hippocampus. Brain research. 2024-04-25. PMID:38663469. |
western blotting and qpcr were used to detect hippocampal nlrp3, caspase-1 and il-1β expression levels on days 3 and 7 post-surgery. |
2024-04-25 |
2024-04-28 |
mouse |
| Zhu Wang, Bowen Li, Jingrui Yang, Ying Gao, Liu Gao, Qiang Jia, Li Yu, Yunzhi Lin. ML365 ameliorates postoperative cognitive impairment in aged mice by inhibiting NLRP3 inflammasome activation in the hippocampus. Brain research. 2024-04-25. PMID:38663469. |
ml365 pretreatment also reduced nlrp3, caspase-1, asc and il-1β expression levels in the hippocampus, improved pocd-induced pathological changes in the hippocampal ca1 and ca3 areas of aged mice, and decreased levels of plasma mda and oxidative stress. |
2024-04-25 |
2024-04-28 |
mouse |
| Zhu Wang, Bowen Li, Jingrui Yang, Ying Gao, Liu Gao, Qiang Jia, Li Yu, Yunzhi Lin. ML365 ameliorates postoperative cognitive impairment in aged mice by inhibiting NLRP3 inflammasome activation in the hippocampus. Brain research. 2024-04-25. PMID:38663469. |
together, our findings indicate that ml365 can alleviate pocd in mice by inhibiting nlrp3 inflammasome activation in the hippocampus. |
2024-04-25 |
2024-04-28 |
mouse |
| Jiahong Shen, Jiawen Xu, Yuxin Wen, Zili Tang, Jiaqi Li, Jianliang Su. Carnosine ameliorates postoperative cognitive dysfunction of aged rats by limiting astrocytes pyroptosis. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2024-04-25. PMID:38664193. |
we found that the administrated of carnosine notably attenuated surgery-induced nlrp3 inflammasome activation and pyroptosis in astrocytes, central inflammation, and neuronal damage in the hippocampus of aged rats. |
2024-04-25 |
2024-04-28 |
rat |
| Lancheng Wei, Hongjian He, Shuting Yang, Qianqian Shi, Xinhang Wang, Liyuan Huang, Jianyong Lu, Yinghui Shen, Kaikai Zhi, Junni Xiang, Chengying Chen, Jiao Mo, Zhijian Zheng, Yunfeng Zou, Xiaobo Yang, Shen Tang, Xiyi Li, Cailing L. Synergistic suppression of BDNF via epigenetic mechanism deteriorating learning and memory impairment caused by Mn and Pb co-exposure. Ecotoxicology and environmental safety. vol 277. 2024-04-24. PMID:38657452. |
we also observe abnormal activation of microglia characterized by enhanced release of the nlrp3 inflammasome, casepase-1 and pro-inflammatory cytokines il-1β, in the hippocampus of mice and bv2 cells. |
2024-04-24 |
2024-04-28 |
mouse |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
nerolidol rescues hippocampal injury of diabetic rats through inhibiting nlrp3 inflammasome and regulation of mapk/akt pathway. |
2024-04-16 |
2024-04-18 |
rat |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
notably, the nlrp3 inflammasome is highly expressed in the hippocampus of diabetic individuals. |
2024-04-16 |
2024-04-18 |
rat |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
immunofluorescence was used to detect gfap, iba1, and nlrp3 expression in the hippocampus. |
2024-04-16 |
2024-04-18 |
rat |
| Yining Lei, Manqin Li, Xinran Liu, Lu Zhang, Ruyi Zhang, Fei Ca. Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway. BioFactors (Oxford, England). 2024-04-16. PMID:38624190. |
further studies revealed that nerolidol decreased neuroinflammation, nlrp3 and inflammatory factor expression in hippocampal tissue while also decreasing mapk pathway expression and enhancing akt pathway expression. |
2024-04-16 |
2024-04-18 |
rat |
| Qi Xu, Lihong Sun, Qing Chen, Cuicui Jiao, Yuan Wang, Hua Li, Jiaqian Xie, Fangfang Zhu, Jiangling Wang, Wen Zhang, Linghua Xie, Hui Wu, Zhiyi Zuo, Xinzhong Che. Gut microbiota dysbiosis contributes to depression-like behaviors via hippocampal NLRP3-mediated neuroinflammation in a postpartum depression mouse model. Brain, behavior, and immunity. 2024-04-10. PMID:38599497. |
also, downregulation of nlrp3 in the hippocampus mitigated depression-like behaviors in ppd mice and overexpression of nlrp3 in the hippocampal dentate gyrus induced depression-like behaviors in naïve female mice. |
2024-04-10 |
2024-04-13 |
mouse |
| Qi Xu, Lihong Sun, Qing Chen, Cuicui Jiao, Yuan Wang, Hua Li, Jiaqian Xie, Fangfang Zhu, Jiangling Wang, Wen Zhang, Linghua Xie, Hui Wu, Zhiyi Zuo, Xinzhong Che. Gut microbiota dysbiosis contributes to depression-like behaviors via hippocampal NLRP3-mediated neuroinflammation in a postpartum depression mouse model. Brain, behavior, and immunity. 2024-04-10. PMID:38599497. |
intriguingly, fmt from healthy mice failed to alleviate depression-like behaviors in ppd mice with nlrp3 overexpression in the hippocampus. |
2024-04-10 |
2024-04-13 |
mouse |
| Zhicheng Gao, Kangxin Luo, Yulin Hu, Yunqian Niu, Xinchao Zhu, Shoujun Li, Haiyang Zhan. Melatonin alleviates chronic stress-induced hippocampal microglia pyroptosis and subsequent depression-like behaviors by inhibiting Cathepsin B/NLRP3 signaling pathway in rats. Translational psychiatry. vol 14. issue 1. 2024-03-28. PMID:38538614. |
in addition, inhibition of cathepsin b and nlrp3 alleviated hippocampal pyroptosis. |
2024-03-28 |
2024-03-30 |
rat |
| Xue Li, Yu Jin, Xianyi Ding, Tongyang Zhu, Changling Wei, Li Ya. Long-term exercise training inhibits inflammation by suppressing hippocampal NLRP3 in APP/PS1 mice. Sports medicine and health science. vol 5. issue 4. 2024-02-05. PMID:38314041. |
long-term exercise training inhibits inflammation by suppressing hippocampal nlrp3 in app/ps1 mice. |
2024-02-05 |
2024-02-07 |
mouse |
| Daniela M Magalhães, Myrthe Mampay, Ana M Sebastião, Graham K Sheridan, Cláudia A Valent. Age-related impact of social isolation in mice: Young vs middle-aged. Neurochemistry international. 2024-01-24. PMID:38266657. |
increased iba-1 expression and nlrp3 priming were both observed in the hippocampus of socially isolated middle-aged mice, suggesting a role for microglia and nlrp3 pathway in the detrimental effects of social isolation on cognition and behaviour. |
2024-01-24 |
2024-01-27 |
mouse |
| Ning Jiang, Yiwen Zhang, Caihong Yao, Fang Chen, Yupei Liu, Yuzhen Chen, Yan Wang, Muhammad Iqbal Choudhary, Xinmin Li. Hemerocallis citrina Baroni ameliorates chronic sleep deprivation-induced cognitive deficits and depressive-like behaviours in mice. Life sciences in space research. vol 40. 2024-01-20. PMID:38245346. |
in summary, our findings indicated that hce attenuated sd-induced cognitive impairment and depression-like behavior and that this effect may be mediated by the inhibition of inflammatory progression and microglial activation in the hippocampus, as well as the down-regulation of nf-κb and nlrp3 signaling. |
2024-01-20 |
2024-01-23 |
mouse |
| Oluwatosin Olalekan Ogedengbe, Halima Saliu, Adedamola Adediran Fafure, Christopher Oloruntoba Akintayo, Adeshina Oloruntoba Adekeye, Basiru Olaitan Ajiboye, Onyemaechi Okpara Az. Hippocampus and Prefrontal Cortex Following the Use of Anti-Retroviral Therapy in Adult Wistar Rats: Therapeutic Role of Epigallocatechin Gallate. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. vol 37. issue 2. 2024-01-20. PMID:38243557. |
treatment with egcg resulted in partial neuronal restoration of histopathological alterations, and modulation of nlrp3 inflammasome in the hippocampus and prefrontal cortex. |
2024-01-20 |
2024-01-22 |
rat |
| Jianxiong Gui, Jie Liu, Lingman Wang, Xiaoyue Yang, Bing Tian, Hanyu Luo, Dishu Huang, Ziyao Han, Jiaxin Yang, Ran Ding, Zhixu Fang, Xue Li, Li Cheng, Li Jian. Autophagy alleviates hippocampal neuroinflammation by inhibiting the NLRP3 inflammasome in a juvenile rat model exposed particulate matter. Toxicology. 2024-01-18. PMID:38237716. |
autophagy alleviates hippocampal neuroinflammation by inhibiting the nlrp3 inflammasome in a juvenile rat model exposed particulate matter. |
2024-01-18 |
2024-01-21 |
rat |
| Jianxiong Gui, Jie Liu, Lingman Wang, Xiaoyue Yang, Bing Tian, Hanyu Luo, Dishu Huang, Ziyao Han, Jiaxin Yang, Ran Ding, Zhixu Fang, Xue Li, Li Cheng, Li Jian. Autophagy alleviates hippocampal neuroinflammation by inhibiting the NLRP3 inflammasome in a juvenile rat model exposed particulate matter. Toxicology. 2024-01-18. PMID:38237716. |
we observed that pm exposure induced the activation of the nlrp3 inflammasome, leading to the production of il-1β and il-18 in the rat hippocampus and bv-2 cells. |
2024-01-18 |
2024-01-21 |
rat |