| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marta Halasa, Ahmed Uosef, Henry V Ubelaker, Arijita Subuddhi, Krupa R Mysore, Jacek Z Kubiak, Rafik M Ghobrial, Jarek Wosik, Malgorzata Klo. Gadolinium retention effect on macrophages - a potential cause of MRI contrast agent Dotarem toxicity. Cell and tissue research. 2024-04-16. PMID:38625373. |
gadolinium retention for 7 days decreased macrophage adhesion and motility and dysregulated the expression of adhesion and fibrotic pathway-related proteins such as notch1 and its ligand jagged1, adhesion/migration-related proteins pak1 and shp1, immune response-related transcription factors smad3 and tcf19, and chemokines cxcl10 and cxcl13, and dysregulated the mrna expression of fibrosis-related genes involved in extracellular matrix (ecm) synthesis, such as col6a1, fibronectin, mmp9, and mmp12. |
2024-04-16 |
2024-04-18 |
Not clear |
| Zhiwei Liao, Wencan Ke, Hui Liu, Bide Tong, Kun Wang, Xiaobo Feng, Wenbin Hua, Bingjin Wang, Yu Song, Rongjin Luo, Huaizhen Liang, Weifeng Zhang, Kangcheng Zhao, Shuai Li, Cao Yan. Vasorin-containing small extracellular vesicles retard intervertebral disc degeneration utilizing an injectable thermoresponsive delivery system. Journal of nanobiotechnology. vol 20. issue 1. 2022-09-19. PMID:36123708. |
in this study, we intensively investigated the therapeutic mechanism of small evs, and found that vasorin protein enriched in evs promoted the proliferation and extracellular matrix anabolism of nucleus pulposus cells via the notch1 signaling pathway. |
2022-09-19 |
2023-08-14 |
Not clear |
| Xing-Mei Liu, Yan Shen, Yu He, Xiao-Xia Ban, Hong-Jun Jin, Xiao-Lan He, He Tia. [Effect of Notch1 on extracellular matrix deposition in the renal tubulointerstitium of diabetes]. Sheng li xue bao : [Acta physiologica Sinica]. vol 74. issue 3. 2022-06-30. PMID:35770637. |
[effect of notch1 on extracellular matrix deposition in the renal tubulointerstitium of diabetes]. |
2022-06-30 |
2023-08-14 |
mouse |
| Xing-Mei Liu, Yan Shen, Yu He, Xiao-Xia Ban, Hong-Jun Jin, Xiao-Lan He, He Tia. [Effect of Notch1 on extracellular matrix deposition in the renal tubulointerstitium of diabetes]. Sheng li xue bao : [Acta physiologica Sinica]. vol 74. issue 3. 2022-06-30. PMID:35770637. |
the aim of the present study was to observe the effects of notch1 and autophagy on extracellular matrix deposition in renal tubulointerstitium of diabetes and to explore the mechanism. |
2022-06-30 |
2023-08-14 |
mouse |
| Xing-Mei Liu, Yan Shen, Yu He, Xiao-Xia Ban, Hong-Jun Jin, Xiao-Lan He, He Tia. [Effect of Notch1 on extracellular matrix deposition in the renal tubulointerstitium of diabetes]. Sheng li xue bao : [Acta physiologica Sinica]. vol 74. issue 3. 2022-06-30. PMID:35770637. |
autophagy was decreased and extracellular matrix deposition was aggravated when notch1 was overexpressed. |
2022-06-30 |
2023-08-14 |
mouse |
| Xing-Mei Liu, Yan Shen, Yu He, Xiao-Xia Ban, Hong-Jun Jin, Xiao-Lan He, He Tia. [Effect of Notch1 on extracellular matrix deposition in the renal tubulointerstitium of diabetes]. Sheng li xue bao : [Acta physiologica Sinica]. vol 74. issue 3. 2022-06-30. PMID:35770637. |
in contrast, autophagy was increased and extracellular matrix deposition was relieved by knockdown of notch1 under hg conditions. |
2022-06-30 |
2023-08-14 |
mouse |
| Xing-Mei Liu, Yan Shen, Yu He, Xiao-Xia Ban, Hong-Jun Jin, Xiao-Lan He, He Tia. [Effect of Notch1 on extracellular matrix deposition in the renal tubulointerstitium of diabetes]. Sheng li xue bao : [Acta physiologica Sinica]. vol 74. issue 3. 2022-06-30. PMID:35770637. |
the extracellular matrix deposition in the renal tubulointerstitium was relieved by regulating autophagy after the knockdown of notch1. |
2022-06-30 |
2023-08-14 |
mouse |
| Ping Zhu, Chuping Chen, Daoai Wu, Guangshu Chen, Rongshao Tan, Jianmin Ra. AGEs-induced MMP-9 activation mediated by Notch1 signaling is involved in impaired wound healing in diabetic rats. Diabetes research and clinical practice. vol 186. 2022-03-20. PMID:35306046. |
to elucidate the relationship between advanced glycation end products (ages), notch1 signaling, nuclear factor-kappa b (nf-κb), and matrix metalloproteinase-9 (mmp-9) in diabetic wound healing in vitro and in vivo. |
2022-03-20 |
2023-08-13 |
rat |
| I Yilmaz, N Karaarslan, D Yasar Sirin, H Ozbe. Pharmaco-molecular assessment of the effects of anandamide and its antagonists on hippocampal tissue in Wistar albino rats. European review for medical and pharmacological sciences. vol 24. issue 22. 2021-07-01. PMID:33275258. |
the present study aimed to investigate the changes in the gene and protein expression levels of matrix metallopeptidase 9 (mmp-9), phosphatase and tensin homolog (pten), and notch receptor 1 (notch1) in rat hippocampal tissues treated with anandamide (aea), am251, 6-iodopravadolin (am630), and n-[4-{[(3,4-dimethyl-5-isoxazolyl)amino]sulfonyl}phenyl] (ml193). |
2021-07-01 |
2023-08-13 |
rat |
| William R Swindell, Krzysztof Bojanowski, Ratan K Chaudhur. A Zingerone Analog, Acetyl Zingerone, Bolsters Matrisome Synthesis, Inhibits Matrix Metallopeptidases, and Represses IL-17A Target Gene Expression. The Journal of investigative dermatology. vol 140. issue 3. 2020-11-09. PMID:31465741. |
both z and az increased notch pathway gene expression (notch1 and maml3) and decreased expression of genes linked to extracellular matrix disassembly (mmp3 and ctsv) and reactive oxygen species metabolism (pmaip1 and arg2). |
2020-11-09 |
2023-08-13 |
human |
| Federica Lo Presti, David G Guzzardi, Ciro Bancone, Paul W M Fedak, Alessandro Della Cort. The science of BAV aortopathy. Progress in cardiovascular diseases. vol 63. issue 4. 2020-10-15. PMID:32599028. |
while genetic studies have so far identified variants relevant to either valve malformation or aortic complications (including those in the genes notch1, tgfbr2, acta2, gata5, nkx2.5, smad6, robo4), however each explaining not more than 5% of the study population, other investigations have thoroughly described both the flow features, with consequent forces acting on the arterial wall (including skewed flow jet direction, rotational flow, wall shear stress), and the main changes in the molecular and cellular wall structure (including extracellular matrix degradation, smooth muscle cell changes, oxidative stress, unbalance of tgf-β signaling, aberrant endothelial-to-mesenchymal transition). |
2020-10-15 |
2023-08-13 |
Not clear |
| Bin Jiang, Jinhuang Chen, Wenzheng Yuan, Jintong Ji, Zhengyi Liu, Liang Wu, Qiang Tang, Xiaogang Sh. Platelet-derived growth factor-D promotes colorectal cancer cell migration, invasion and proliferation by regulating Notch1 and matrix metalloproteinase-9. Oncology letters. vol 15. issue 2. 2020-10-01. PMID:29434852. |
platelet-derived growth factor-d promotes colorectal cancer cell migration, invasion and proliferation by regulating notch1 and matrix metalloproteinase-9. |
2020-10-01 |
2023-08-13 |
human |
| Bin Jiang, Jinhuang Chen, Wenzheng Yuan, Jintong Ji, Zhengyi Liu, Liang Wu, Qiang Tang, Xiaogang Sh. Platelet-derived growth factor-D promotes colorectal cancer cell migration, invasion and proliferation by regulating Notch1 and matrix metalloproteinase-9. Oncology letters. vol 15. issue 2. 2020-10-01. PMID:29434852. |
silencing pdgf-d in the sw480 cell line inhibited migration, invasion and proliferation distinctly, with reduced expression of notch1 and matrix metalloproteinase-9. |
2020-10-01 |
2023-08-13 |
human |
| Na Li, Ling Zhang, Qi Li, Yu Du, Hengwei Liu, Yi Liu, Wenqian Xion. Notch activity mediates oestrogen-induced stromal cell invasion in endometriosis. Reproduction (Cambridge, England). vol 157. issue 4. 2019-09-30. PMID:30753135. |
primary stromal cells obtained from normal endometria cultured with oestrogen presented significant increases in the expression of notch components and notch activity, the cytoplasmic and nuclear accumulation of notch1 intracellular domain, the expression of matrix metallopeptidase 9 and vascular endothelial growth factor and cell invasiveness. |
2019-09-30 |
2023-08-13 |
Not clear |
| Na Li, Ling Zhang, Qi Li, Yu Du, Hengwei Liu, Yi Liu, Wenqian Xion. Notch activity mediates oestrogen-induced stromal cell invasion in endometriosis. Reproduction (Cambridge, England). vol 157. issue 4. 2019-09-30. PMID:30753135. |
knockdown of notch1 markedly alleviated oestrogen-induced matrix metallopeptidase 9 and vascular endothelial growth factor expression and cell invasion. |
2019-09-30 |
2023-08-13 |
Not clear |
| Chun-Tao Lei, Hui Tang, Chen Ye, Chao-Qun You, Jiao Zhang, Chun-Yun Zhang, Wei Xiong, Hua Su, Chun Zhan. MDM2 Contributes to High Glucose-Induced Glomerular Mesangial Cell Proliferation and Extracellular Matrix Accumulation via Notch1. Scientific reports. vol 7. issue 1. 2019-06-04. PMID:28871126. |
mdm2 contributes to high glucose-induced glomerular mesangial cell proliferation and extracellular matrix accumulation via notch1. |
2019-06-04 |
2023-08-13 |
mouse |
| Lijiao Pei, Xiaoqian He, Shuman Li, Ran Sun, Qin Xiang, Guosheng Ren, Tingxiu Xian. KRAB zinc-finger protein 382 regulates epithelial-mesenchymal transition and functions as a tumor suppressor, but is silenced by CpG methylation in gastric cancer. International journal of oncology. vol 53. issue 3. 2018-11-26. PMID:29956735. |
znf382 expression downregulated the expression of snail, vimentin, twist, notch1, notch2, notch3, notch4, hes-1, jag1, matrix metalloproteinase (mmp)2 and mmp11, as well as that of the stem cell markers, nanog, octamer-binding transcription factor 4 (oct4) and sox2. |
2018-11-26 |
2023-08-13 |
Not clear |
| Bin Sun, Changxian Dong, Hongzhao Lei, Yubin Gong, Miaomiao Li, Yuanfang Zhang, Hongyu Zhang, Longlong Su. Propranolol inhibits proliferation and invasion of hemangioma-derived endothelial cells by suppressing the DLL4/Notch1/Akt pathway. Chemico-biological interactions. vol 294. 2018-09-14. PMID:30130526. |
the expressions of matrix metalloproteinase (mmp)-2, mmp-9, delta-like 4 (dll4), notch1, akt, p-akt, and vascular endothelial growth factor (vegf) were detected using western blot. |
2018-09-14 |
2023-08-13 |
human |
| Chen Jue, Wu Zhifeng, Zhang Zhisheng, Cui Lin, Qian Yayun, Jin Feng, Gu Hao, Ishikawa Shintaro, Tadashi Hisamitsu, Guo Shiyu, Liu Yanqin. Vasculogenic mimicry in hepatocellular carcinoma contributes to portal vein invasion. Oncotarget. vol 7. issue 47. 2018-03-20. PMID:27793002. |
the regulatory molecules of vm formation such as notch1, vimentin and matrix metalloproteinases (mmps) were investigated by immunohistochemical staining. |
2018-03-20 |
2023-08-13 |
Not clear |
| Fei Han, Shanshan Wang, Yunpeng Chang, Chunjun Li, Juhong Yang, Zhe Han, Baocheng Chang, Bei Sun, Liming Che. Triptolide prevents extracellular matrix accumulation in experimental diabetic kidney disease by targeting microRNA-137/Notch1 pathway. Journal of cellular physiology. vol 233. issue 3. 2017-12-12. PMID:28695984. |
and triptolide also inhibited extracellular matrix (ecm) protein accumulation and the notch1 pathway activation under diabetic conditions. |
2017-12-12 |
2023-08-13 |
rat |