| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marta Halasa, Ahmed Uosef, Henry V Ubelaker, Arijita Subuddhi, Krupa R Mysore, Jacek Z Kubiak, Rafik M Ghobrial, Jarek Wosik, Malgorzata Klo. Gadolinium retention effect on macrophages - a potential cause of MRI contrast agent Dotarem toxicity. Cell and tissue research. 2024-04-16. PMID:38625373. |
gadolinium retention for 7 days decreased macrophage adhesion and motility and dysregulated the expression of adhesion and fibrotic pathway-related proteins such as notch1 and its ligand jagged1, adhesion/migration-related proteins pak1 and shp1, immune response-related transcription factors smad3 and tcf19, and chemokines cxcl10 and cxcl13, and dysregulated the mrna expression of fibrosis-related genes involved in extracellular matrix (ecm) synthesis, such as col6a1, fibronectin, mmp9, and mmp12. |
2024-04-16 |
2024-04-18 |
Not clear |
| Payaningal R Somanath, Jonathan Chernoff, Brian S Cummings, Sandip M Prasad, Harvey D Homa. Targeting P21-Activated Kinase-1 for Metastatic Prostate Cancer. Cancers. vol 15. issue 8. 2023-05-16. PMID:37190165. |
group-i paks (pak1, pak2, and pak3) are involved in the regulation of actin dynamics and thus are integral for cell morphology, adhesion to the extracellular matrix, and cell motility. |
2023-05-16 |
2023-08-14 |
mouse |
| Wanli Ma, Xiaohe Wang, Chunhui Wang, Mingzhi Gong, Peng Re. Up-regulation of P21-activated kinase 1 in osteoarthritis chondrocytes is responsible for osteoarthritic cartilage destruction. Bioscience reports. vol 40. issue 1. 2021-03-16. PMID:31868209. |
furthermore, we found that pak1 modulated the production of extracellular matrix and cartilage degrading enzymes in chondrocytes. |
2021-03-16 |
2023-08-13 |
rat |
| Roger R Markwald, Ricardo A Moreno-Rodriguez, Sibnath Ghatak, Suniti Misra, Russell A Norris, Yukiko Sug. Role of Periostin in Cardiac Valve Development. Advances in experimental medicine and biology. vol 1132. 2019-08-08. PMID:31037635. |
these morphogenetic activities are promoted or coordinated by periostin signaling through integrin receptors activating downstream kinases in cushion cells that activate hyaluronan synthetase ii (akt/pi3k), collagen synthesis (erk/mapk) and changes in cytoskeletal organization (pak1) which regulate postnatal remodeling of cells and associated collagenous matrix into a trilaminar (zonal) histoarchitecture. |
2019-08-08 |
2023-08-13 |
Not clear |
| Liang-Hui Li, Guo-Yang Wu, Yi-Zhuo Lu, Xue-Hua Chen, Bing-Ya Liu, Min-Hua Zheng, Jian-Chun Ca. p21-activated protein kinase 1 induces the invasion of gastric cancer cells through c-Jun NH2-terminal kinase-mediated activation of matrix metalloproteinase-2. Oncology reports. vol 38. issue 1. 2018-04-06. PMID:28534988. |
by qrt-pcr and gelatin zymograph assay, we demonstrated in the present study that stable overexpression of pak1 induced matrix metalloproteinase (mmp)-2 mrna expression and activity in the human mkn45 gc cell line. |
2018-04-06 |
2023-08-13 |
human |
| Sankar Jagadeeshan, R Vivek Sagayaraj, Navina Paneerselvan, Syed Shabin Ghouse, Raghunathan Malath. Toxicity and anti-angiogenicity evaluation of Pak1 inhibitor IPA-3 using zebrafish embryo model. Cell biology and toxicology. vol 33. issue 1. 2017-09-29. PMID:27581547. |
we provide novel evidence that pak1 inhibitor could act as anti-angiogenic agents by impeding the development of sub-intestinal vessel (siv) and intersegmental vessels (isvs) by suppressing the expression of vascular endothelial growth factor (vegf), vegf receptor 2 (vegfr2), neurophilin 1 (nrp1) and its downstream genes matrix metalloproteinase (mmp)-2 and mmp-9. |
2017-09-29 |
2023-08-13 |
zebrafish |
| S Jagadeeshan, Y R Krishnamoorthy, M Singhal, A Subramanian, J Mavuluri, A Lakshmi, A Roshini, G Baskar, M Ravi, L D Joseph, K Sadasivan, A Krishnan, A S Nair, G Venkatraman, S K Rayal. Transcriptional regulation of fibronectin by p21-activated kinase-1 modulates pancreatic tumorigenesis. Oncogene. vol 34. issue 4. 2015-04-08. PMID:24561527. |
by adopting a quantitative pcr array-based approach, we identified fibronectin, a component of the extracellular matrix and a mesenchymal marker, as a transcriptional target of pak1 signaling. |
2015-04-08 |
2023-08-12 |
mouse |
| Leah Rider, Peter Oladimeji, Maria Diakonov. PAK1 regulates breast cancer cell invasion through secretion of matrix metalloproteinases in response to prolactin and three-dimensional collagen IV. Molecular endocrinology (Baltimore, Md.). vol 27. issue 7. 2014-04-17. PMID:23744893. |
three-dimensional (3d) collagen iv stimulates the secretion of the matrix proteases, metalloproteinase (mmp)-1 and -3 that is further enhanced by the prl-dependent tyrosyl phosphorylation of pak1. |
2014-04-17 |
2023-08-12 |
human |
| Leah Rider, Peter Oladimeji, Maria Diakonov. PAK1 regulates breast cancer cell invasion through secretion of matrix metalloproteinases in response to prolactin and three-dimensional collagen IV. Molecular endocrinology (Baltimore, Md.). vol 27. issue 7. 2014-04-17. PMID:23744893. |
pak1 regulates breast cancer cell invasion through secretion of matrix metalloproteinases in response to prolactin and three-dimensional collagen iv. |
2014-04-17 |
2023-08-12 |
human |
| Anna Goc, Ahmad Al-Azayzih, Maha Abdalla, Belal Al-Husein, Sravankumar Kavuri, Jeffrey Lee, Kelvin Moses, Payaningal R Somanat. P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretion. The Journal of biological chemistry. vol 288. issue 5. 2013-03-28. PMID:23258534. |
p21 activated kinase-1 (pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretion. |
2013-03-28 |
2023-08-12 |
Not clear |
| Anna Goc, Ahmad Al-Azayzih, Maha Abdalla, Belal Al-Husein, Sravankumar Kavuri, Jeffrey Lee, Kelvin Moses, Payaningal R Somanat. P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretion. The Journal of biological chemistry. vol 288. issue 5. 2013-03-28. PMID:23258534. |
finally, gene array data revealed reduced expression of matrix metalloproteinase 9 with the ablation of either pak1 or pak6 gene expression in pc3 cells, whereas protein levels of tgfβ was elevated significantly with specific modulation of pak1 activity or ablation of the pak1 gene. |
2013-03-28 |
2023-08-12 |
Not clear |
| Jeanine Pignatelli, Sara E LaLonde, David P LaLonde, Dominic Clarke, Christopher E Turne. Actopaxin (α-parvin) phosphorylation is required for matrix degradation and cancer cell invasion. The Journal of biological chemistry. vol 287. issue 44. 2013-01-07. PMID:22955285. |
furthermore, actopaxin forms a complex with the rac1/cdc42 gef β-pix and rac1/cdc42 effector pak1, to regulate actopaxin-dependent matrix degradation. |
2013-01-07 |
2023-08-12 |
Not clear |
| Julia V Kichina, Anna Goc, Belal Al-Husein, Payaningal R Somanath, Eugene S Kande. PAK1 as a therapeutic target. Expert opinion on therapeutic targets. vol 14. issue 7. 2010-09-21. PMID:20507214. |
cell motility, survival and proliferation, the organization and function of cytoskeleton and extracellular matrix, transcription and translation are among the processes affected by pak1. |
2010-09-21 |
2023-08-12 |
Not clear |
| Sivan Elloul, Olga Vaksman, Helene Tuft Stavnes, Claes G Trope, Ben Davidson, Reuven Reic. Mesenchymal-to-epithelial transition determinants as characteristics of ovarian carcinoma effusions. Clinical & experimental metastasis. vol 27. issue 3. 2010-04-22. PMID:20213325. |
using dominant negative (dn) and constitutively active (ca) pak1 constructs, we found that dn pak1 es-2 and ovcar-3 clones had reduced attachment to matrix proteins, invasion and mmp-2 activity compared to ca and wild-type cells. |
2010-04-22 |
2023-08-12 |
Not clear |
| Martina Nagel, Olivia Luu, Nicolas Bisson, Bojan Macanovic, Tom Moss, Rudolf Winklbaue. Role of p21-activated kinase in cell polarity and directional mesendoderm migration in the Xenopus gastrula. Developmental dynamics : an official publication of the American Association of Anatomists. vol 238. issue 7. 2009-09-24. PMID:19504461. |
however, pak1 inhibition interferes with the guidance of mesendoderm migration by directional cues residing in the extracellular matrix of the blastocoel roof, and with mesendoderm translocation in the embryo. |
2009-09-24 |
2023-08-12 |
xenopus_laevis |
| Julie C Friedland, Johnathon N Lakins, Marcelo G Kazanietz, Jonathan Chernoff, David Boettiger, Valerie M Weave. alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini. Journal of cell science. vol 120. issue Pt 20. 2008-01-28. PMID:17911169. |
our data emphasize the importance of the extracellular matrix stroma in tissue survival and suggest that alpha6beta4 integrin-dependent rac stimulation of pak1 could be an important mechanism mediating apoptosis-resistance in some breast tumors. |
2008-01-28 |
2023-08-12 |
Not clear |
| Sangmyung Rhee, Frederick Grinnel. P21-activated kinase 1: convergence point in PDGF- and LPA-stimulated collagen matrix contraction by human fibroblasts. The Journal of cell biology. vol 172. issue 3. 2006-04-25. PMID:16449192. |
we also show that, depending on the agonist, different rho effectors cooperate with pak1 to regulate matrix contraction, rho kinase in the case of pdgf and mdia1 in the case of lpa. |
2006-04-25 |
2023-08-12 |
human |
| Sangmyung Rhee, Frederick Grinnel. P21-activated kinase 1: convergence point in PDGF- and LPA-stimulated collagen matrix contraction by human fibroblasts. The Journal of cell biology. vol 172. issue 3. 2006-04-25. PMID:16449192. |
in this study, we show that the pdgf and lpa signaling pathways required for matrix contraction converge on p21-activated kinase 1 (pak1) and its downstream effector cofilin1 and that contraction depends on cellular ruffling activity, rather than on the protrusion and retraction of cellular dendritic extensions. |
2006-04-25 |
2023-08-12 |
human |
| M C Parrini, M Matsuda, J de Gunzbur. Spatiotemporal regulation of the Pak1 kinase. Biochemical Society transactions. vol 33. issue Pt 4. 2005-12-14. PMID:16042564. |
moreover, pak1 is dynamically engaged into multiprotein complexes forming adhesions to the extracellular matrix. |
2005-12-14 |
2023-08-12 |
Not clear |
| Scott T Eblen, Jill K Slack, Michael J Weber, Andrew D Catlin. Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes. Molecular and cellular biology. vol 22. issue 17. 2002-09-09. PMID:12167697. |
however, upon replating of cells onto a fibronectin matrix, there was a substantial induction of mek1-erk2 association and erk activation, both of which could be inhibited by dominant-negative pak1. |
2002-09-09 |
2023-08-12 |
Not clear |