| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cécilia Tremblay, Sidra Aslam, Jessica E Walker, Ileana Lorenzini, Anthony J Intorcia, Richard A Arce, Parichita Choudhury, Charles H Adler, Holly A Shill, Erika Driver-Dunckley, Shyamal Mehta, Ignazio S Piras, Christine M Belden, Alireza Atri, Thomas G Beach, Geidy E Serran. RNA sequencing of olfactory bulb in Parkinson's disease reveals gene alterations associated with olfactory dysfunction. Neurobiology of disease. 2024-04-25. PMID:38663633. |
lair1 (leukocyte associated immunoglobulin like receptor 1) and ppara (peroxisome proliferator activated receptor alpha) were identified as hub genes with a high discriminative power between pd and controls reinforcing an important role of neuroinflammation in the olfactory bulb of pd subjects. |
2024-04-25 |
2024-04-28 |
human |
| Beata Lecka-Czernik, Mohd Parvez Khan, Joshua Letson, Sudipta Baroi, Amit Chougul. Regulatory Effect of Osteocytes on Extramedullary and Bone Marrow Adipose Tissue Development and Function. Current osteoporosis reports. 2024-04-16. PMID:38625510. |
this review summarizes evidence on osteocyte support of extramedullary and bone marrow adipocyte development and discusses the role of endogenous osteocyte activities of nuclear receptors peroxisome proliferator-activated receptor gamma (pparg) and alpha (ppara) in this support. |
2024-04-16 |
2024-04-18 |
Not clear |
| Yanping Li, Feng Yang, Wanying Lang, Qi An, Zhi Pan, Wenyu Shi, Xiaowei Sh. Network pharmacology and pharmacological evaluation of Wenzheng Jiedu Powder Modified Formula for neuropathic pain relief. General physiology and biophysics. vol 43. issue 2. 2024-03-13. PMID:38477604. |
wjpmf significantly improved pain behaviors in sni rats by regulating atp-binding cassette transporter a1 (abca1), peroxisome proliferator-activated receptor alpha (ppara), peroxisome proliferator-activated receptor gamma (pparg), and superoxide dismutase 2 (sod2) expression, which were key targets involved in the peroxisome proliferator-activated receptor (ppar) signaling pathway. |
2024-03-13 |
2024-03-15 |
rat |
| Kun Ma, Junhui Chu, Yufeng Liu, Linmao Sun, Shuo Zhou, Xianying Li, Changyong Ji, Ning Zhang, Xinyu Guo, Shuhang Liang, Tianming Cui, Qingsong Hu, Jiabei Wang, Yao Liu, Lianxin Li. Hepatocellular Carcinoma LINC01116 Outcompetes T Cells for Linoleic Acid and Accelerates Tumor Progression. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-03-09. PMID:38460179. |
the enhanced ewsr1 protein upregulates peroxisome proliferator activated receptor alpha (ppara) and fatty acid binding protein1 (fabp1) expression, a long-chain fatty acid (lcfa) transporter, and thus cancer cells outcompete t cells for lcfas, especially linoleic acid, for seeding their own growth, leading to t cell malfunction and hcc malignant progression. |
2024-03-09 |
2024-03-12 |
Not clear |
| Daisuke Aibar. [Epigenetic Regulation of Gene Expression and Hepatocyte Proliferation by Nuclear Receptor PPARA]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 144. issue 2. 2024-02-06. PMID:38296491. |
chronic activation of the nuclear receptor, peroxisome proliferator-activated receptor alpha (ppara), causes hepatocellular proliferation and increases the incidence of hepatocellular carcinoma in rodents. |
2024-02-06 |
2024-02-09 |
mouse |
| Derya Kazancı, Tolga Polat, Ömer Kaynar, Muhammet Fatih Bilici, Beste Tacal Aslan, Korkut Uluca. PPARA and IL6: exploring associations with athletic performance and genotype polymorphism. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 11. 2023-11-28. PMID:38015538. |
this study aims to investigate the interleukin (il)-6 rs1800795 and peroxisome proliferator-activated receptor alpha (ppara) rs4253778 polymorphism distributions in the relatively faster and slower subgroups of national cross-country skiing athletes and to identify advantageous genotypes for endurance performance. |
2023-11-28 |
2023-11-29 |
human |
| Qiannan Ren, Qiming Sun, Junfen F. Dysfunction of autophagy in high-fat diet-induced nonalcoholic fatty liver disease. Autophagy. 2023-09-13. PMID:37700498. |
acox1: acyl-coa oxidase 1; adh5: alcohol dehydrogenase 5 (class iii), chi polypeptide; adipoq: adiponectin, c1q and collagen domain containing; atg: autophagy related; becn1: beclin 1; crtc2: creb regulated transcription coactivator 2; er: endoplasmic reticulum; f2rl1: f2r like trypsin receptor 1; fa: fatty acid; foxo1: forkhead box o1; glp1r: glucagon like peptide 1 receptor; grk2: g protein-coupled receptor kinase 2; gtpase: guanosine triphosphatase; hfd: high-fat diet; hscs: hepatic stellate cells; htra2: htra serine peptidase 2; irgm: immunity related gtpase m; kd: knockdown; kdm6b: lysine demethylase 6b; ko: knockout; lamp2: lysosomal associated membrane protein 2; lap: lc3-associated phagocytosis; lds: lipid droplets; li ko: liver-specific knockout; lsecs: liver sinusoidal endothelial cells; map1lc3/lc3: microtubule associated protein 1 light chain 3; map3k5: mitogen-activated protein kinase kinase kinase 5; med1: mediator complex subunit 1; mtor: mechanistic target of rapamycin kinase; mtorc1: mechanistic target of rapamycin complex 1; nafld: non-alcoholic fatty liver disease; nash: non-alcoholic steatohepatitis; nfe2l2: nfe2 like bzip transcription factor 2; nos3: nitric oxide synthase 3; nr1h3: nuclear receptor subfamily 1 group h member 3; oa: oleic acid; oe: overexpression; osbpl8: oxysterol binding protein like 8; pa: palmitic acid; rubcnl: rubicon like autophagy enhancer; plin2: perilipin 2; plin3: perilipin 3; ppara: peroxisome proliferator activated receptor alpha; prkaa2/ampk: protein kinase amp-activated catalytic subunit alpha 2; rab: member ras oncogene family; rptor: regulatory associated protein of mtor complex 1; scd: stearoyl-coa desaturase; sirt1: sirtuin 1; sirt3: sirtuin 3; snare: soluble n-ethylmaleimide-sensitive factor attachment protein receptor; sqstm1/p62: sequestosome 1; srebf1: sterol regulatory element binding transcription factor 1;srebf2: sterol regulatory element binding transcription factor 2; sting1: stimulator of interferon response cgamp interactor 1; stx17: syntaxin 17; tags: triacylglycerols; tfeb: transcription factor eb; tp53/p53: tumor protein p53; ulk1: unc-51 like autophagy activating kinase 1; vmp1: vacuole membrane protein 1. |
2023-09-13 |
2023-10-07 |
Not clear |
| Xixi Xiang, Fu Li, Sha Zhou, Yunjing Zeng, Xiaojuan Deng, Hongyang Zhang, Jiali Li, Hongyun Liu, Jun Rao, Lei Gao, Cheng Zhang, Qin Wen, Li Gao, Xi Zhan. Significance of PPARA as a Treatment Target for Chronic Lymphocytic Leukemia. PPAR research. vol 2023. 2023-07-05. PMID:37404899. |
peroxisome proliferator-activated receptor alpha (ppara) has been suggested as a therapeutic target for chronic lymphocytic leukemia (cll). |
2023-07-05 |
2023-08-14 |
Not clear |
| Frangky Sangande, Kurnia Agustini, Krisyanti Budipraman. Antihyperlipidemic mechanisms of a formula containing Curcuma xanthorrhiza, Sechium edule, and Syzigium polyanthum: In silico and in vitro studies. Computational biology and chemistry. vol 105. 2023-07-01. PMID:37392529. |
based on the topology parameters, we identified 6 significant targets that play an important role in reducing lipid serum levels: hmg-coa reductase (hmgcr), peroxisome proliferator-activated receptor alpha (ppara), rac-alpha serine/threonine-protein kinase (akt1), epidermal growth factor receptor (egfr), matrix metalloproteinase-9 (mmp9), and tumor necrosis factor-alpha (tnf). |
2023-07-01 |
2023-08-14 |
Not clear |
| Shan Xin, Joel A Schic. PUFAs dictate the balance of power in ferroptosis. Cell calcium. vol 110. 2023-02-11. PMID:36773492. |
slc47a1 is transactivated by peroxisome proliferator activated receptor alpha (ppara). |
2023-02-11 |
2023-08-14 |
Not clear |
| Zhi Lin, Jiao Liu, Fei Long, Rui Kang, Guido Kroemer, Daolin Tang, Minghua Yan. The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis. Nature communications. vol 13. issue 1. 2022-12-27. PMID:36575162. |
we identified peroxisome proliferator activated receptor alpha (ppara) as a transcription factor that transactivates slc47a1. |
2022-12-27 |
2023-08-14 |
mouse |
| Haiyu Li, Yongyao Tang, Yujing Wang, Yue Li, Yi Yang, Kui Liao, Fangzhou Song, Shixiong Deng, Yaokai Che. Single-cell sequencing resolves the landscape of immune cells and regulatory mechanisms in HIV-infected immune non-responders. Cell death & disease. vol 13. issue 10. 2022-10-04. PMID:36195585. |
single-cell assays for transposase-accessible chromatin (scatac-seq) and flow cytometry revealed diminished mitochondrial fitness in mait cells from inrs, and mait had low expression of transcription factor a for mitochondria (tfam) and peroxisomal proliferator-activated receptor alpha (ppara). |
2022-10-04 |
2023-08-14 |
human |
| Samuel K Handelman, Yindra M Puentes, Annapurna Kuppa, Yanhua Chen, Xiaomeng Du, Mary F Feitosa, Nicholette D Palmer, Elizabeth K Speliote. Population-based meta-analysis and gene-set enrichment identifies FXR/RXR pathway as common to fatty liver disease and serum lipids. Hepatology communications. 2022-09-13. PMID:36098472. |
credible genes (proteins) in fxr/rxr activation include those associated with cholesterol/bile/bilirubin transport/absorption (abcc2 (mrp2) [atp binding cassette subfamily c member (multidrug resistance-associated protein 2)], abcg5, abcg8 [atp-binding cassette (abc) transporters g5 and g8], apob (apob) [apolipoprotein b], fabp6 (ilbp) [fatty acid binding protein 6 (ileal lipid-binding protein)], mttp (mtp) [microsomal triglyceride transfer protein], slc4a2 (ae2) [solute carrier family 4 member 2 (anion exchange protein 2)]), nuclear hormone-mediated control of metabolism (nr0b2 (shp) [nuclear receptor subfamily 0 group b member 2 (small heterodimer partner)], nr1h4 (fxr) [nuclear receptor subfamily 1 group h member 4 (fxr)], ppara (ppar) [peroxisome proliferator activated receptor alpha], foxo1 (foxo1a) [forkhead box o1]), or other pathways (fetub (fetub) [fetuin b]). |
2022-09-13 |
2023-08-14 |
human |
| Zhong Chen, Charles Wang, Arlin Blood, Shannon Bragg, Eugenia Mata-Greenwoo. Renal functional, transcriptome, and methylome adaptations in pregnant Sprague Dawley and Brown Norway rats. PloS one. vol 17. issue 6. 2022-06-16. PMID:35709218. |
key upstream regulators included peroxisome-proliferator-activated receptor alpha (ppara), platelet-derived growth factor b dimer (pdgf-bb), and nf-kb p65 (rela). |
2022-06-16 |
2023-08-14 |
rat |
| Xiumei He, Yueyue Fen. MicroRNA hsa-miR-657 promotes retinoblastoma malignancy by inhibiting peroxisome proliferator-activated receptor alpha expression. Anti-cancer drugs. 2022-03-24. PMID:35324527. |
our study aimed to evaluate the potential interaction between microrna mir-657 and the peroxisome proliferator-activated receptor alpha (ppara) in retinoblastoma. |
2022-03-24 |
2023-08-13 |
mouse |
| Yutao Wang, Jinshen Wang, Yuhua Zhao, Pingxiang Liu, Da Cai, Xiao Zhang, Lei Ga. Regulatory mechanisms of Beta-carotene and BCMO1 in adipose tissues: A gene enrichment-based bioinformatics analysis. Human & experimental toxicology. vol 41. 2022-03-21. PMID:35306905. |
besides, ppara (peroxisome proliferator-activated receptor alpha), acly (atp-citrate lyase) and fabp5 (fatty acid-binding protein 5) genes constituted functional partners with many genes in the ppi network, and these genes may be bcmo1 targeting molecules. |
2022-03-21 |
2023-08-13 |
mouse |
| Andrew M Jobbins, Nejc Haberman, Natalia Artigas, Christopher Amourda, Helen A B Paterson, Sijia Yu, Samuel J I Blackford, Alex Montoya, Marian Dore, Yi-Fang Wang, Alessandro Sardini, Inês Cebola, Johannes Zuber, Sheikh Tamir Rashid, Boris Lenhard, Santiago Verni. Dysregulated RNA polyadenylation contributes to metabolic impairment in non-alcoholic fatty liver disease. Nucleic acids research. 2022-03-16. PMID:35293570. |
consistently, inactivation of srsf10 in mouse and human hepatocytes in vitro, and in mouse liver in vivo, was found to dysregulate polyadenylation of key metabolic genes such as peroxisome proliferator-activated receptor alpha (ppara) and exacerbate diet-induced metabolic dysfunction. |
2022-03-16 |
2023-08-13 |
mouse |
| Poonam Dhillon, Jihwan Park, Carmen Hurtado Del Pozo, Lingzhi Li, Tomohito Doke, Shizheng Huang, Juanjuan Zhao, Hyun Mi Kang, Rojesh Shrestra, Michael S Balzer, Shatakshee Chatterjee, Patricia Prado, Seung Yub Han, Hongbo Liu, Xin Sheng, Pieterjan Dierickx, Kirill Batmanov, Juan P Romero, Felipe Prósper, Mingyao Li, Liming Pei, Junhyong Kim, Nuria Montserrat, Katalin Suszta. The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation. Cell metabolism. vol 33. issue 2. 2021-11-29. PMID:33301705. |
coupling of cell differentiation and the metabolism was established by nuclear receptors (estrogen-related receptor alpha [esrra] and peroxisomal proliferation-activated receptor alpha [ppara]) that directly control metabolic and pt-cell-specific gene expression in mice and patient samples while protecting from kidney disease in the mouse model. |
2021-11-29 |
2023-08-13 |
mouse |
| Chenhan Zhong, Li He, Sun-Young Lee, Hang Chang, Yuqing Zhang, David W Threadgill, Ying Yuan, Fuling Zhou, Susan E Celniker, Yankai Xia, Antoine M Snijders, Jian-Hua Ma. Host genetics and gut microbiota cooperatively contribute to azoxymethane-induced acute toxicity in Collaborative Cross mice. Archives of toxicology. vol 95. issue 3. 2021-10-27. PMID:33458792. |
genes located within these qtl, including peroxisome proliferator-activated receptor alpha (ppara), were enriched for enzyme activator and nucleoside-triphosphatase regulator activity. |
2021-10-27 |
2023-08-13 |
mouse |
| Hongyan Ding, Yu Li, Leihong Liu, Ning Hao, Suping Zou, Qianming Jiang, Yusheng Liang, Nana Ma, Shibing Feng, Xichun Wang, Jinjie Wu, Juan J Loo. Sirtuin 1 is involved in oleic acid-induced calf hepatocyte steatosis via alterations in lipid metabolism-related proteins. Journal of animal science. vol 99. issue 10. 2021-10-07. PMID:34436591. |
calf hepatocytes were cultured and incubated with oa (0.25 mm) for 24 h, followed by adenoviral ad-gfp-sirt1-e or ad-gfp-sirt1-n transduction for 48 h. overexpression of sirt1 led to greater protein and mrna abundance of sirt1 along with fatty acid oxidation-related genes including ppargc1a, peroxisome proliferator-activated receptor alpha (ppara), retinoid x receptor α (rxra), and ratio of phospho-acetyl-coa carboxylase alpha (p-acaca)/total acetyl-coa carboxylase alpha (acaca). |
2021-10-07 |
2023-08-13 |
cattle |