| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruirui Li, Ruirui Zhu, Xintong Yang, Ye Feng, Qin He, Haopeng Wang, Qingyou Liu, Deshun Shi, Jieping Huan. The role of lncFABP4 in modulating adipogenic differentiation in buffalo intramuscular preadipocytes. Animal science journal = Nihon chikusan Gakkaiho. vol 95. issue 1. 2024-05-04. PMID:38703069. |
moreover, lncfabp4 significantly increased intramuscular preadipocyte differentiation, as indicated by an increase in the expression of the adipogenic markers peroxisome proliferator-activated receptor gamma (pparg), ccaat enhancer binding protein alpha (c/ebpα), and fabp4. |
2024-05-04 |
2024-05-07 |
Not clear |
| Beata Lecka-Czernik, Mohd Parvez Khan, Joshua Letson, Sudipta Baroi, Amit Chougul. Regulatory Effect of Osteocytes on Extramedullary and Bone Marrow Adipose Tissue Development and Function. Current osteoporosis reports. 2024-04-16. PMID:38625510. |
this review summarizes evidence on osteocyte support of extramedullary and bone marrow adipocyte development and discusses the role of endogenous osteocyte activities of nuclear receptors peroxisome proliferator-activated receptor gamma (pparg) and alpha (ppara) in this support. |
2024-04-16 |
2024-04-18 |
Not clear |
| Yanping Li, Feng Yang, Wanying Lang, Qi An, Zhi Pan, Wenyu Shi, Xiaowei Sh. Network pharmacology and pharmacological evaluation of Wenzheng Jiedu Powder Modified Formula for neuropathic pain relief. General physiology and biophysics. vol 43. issue 2. 2024-03-13. PMID:38477604. |
wjpmf significantly improved pain behaviors in sni rats by regulating atp-binding cassette transporter a1 (abca1), peroxisome proliferator-activated receptor alpha (ppara), peroxisome proliferator-activated receptor gamma (pparg), and superoxide dismutase 2 (sod2) expression, which were key targets involved in the peroxisome proliferator-activated receptor (ppar) signaling pathway. |
2024-03-13 |
2024-03-15 |
rat |
| Prakash P Praharaj, Srimanta Patra, Amruta Singh, Debasna P Panigrahi, Hwa Y Lee, Mohammad F Kabir, Muhammad K Hossain, Samir K Patra, Birija S Patro, Shankargouda Patil, Daniel J Klionsky, Han J Chae, Sujit K Bhuti. CLU (clusterin) and PPARGC1A/PGC1α coordinately control mitophagy and mitochondrial biogenesis for oral cancer cell survival. Autophagy. 2024-03-06. PMID:38447939. |
in parallel, we determined that ppargc1a/pgc1α (pparg coactivator 1 alpha) activates mitochondrial biogenesis during clu-induced mitophagy to maintain the mitochondrial pool. |
2024-03-06 |
2024-03-09 |
Not clear |
| Meng Zhang, Yuanzhan Yang, Zhu Zhu, Zixuan Chen, Dongyang Huan. Implications of Activating the ANT2/mTOR/PGC-1α Feedback Loop: Insights into Mitochondria-Mediated Injury in Hypoxic Myocardial Cells. Current issues in molecular biology. vol 45. issue 11. 2023-11-25. PMID:37998720. |
additionally, we discovered that ant2 is involved in myocardial apoptosis by activating the mtor (mechanistic target of rapamycin kinase)-dependent pgc-1α (pparg coactivator 1 alpha) pathway, establishing a novel feedback loop during ami. |
2023-11-25 |
2023-11-28 |
mouse |
| Mohd Zahoor Ul Haq Shah, Vinoy Kumar Shrivastava, Shazia Sofi, Yahya F Jamous, Mohd Faiyaz Khan, Faisal K Alkholifi, Wasim Ahmad, Manzoor Ahmad Mi. Chlorogenic Acid Restores Ovarian Functions in Mice with Letrozole-Induced Polycystic Ovarian Syndrome Via Modulation of Adiponectin Receptor. Biomedicines. vol 11. issue 3. 2023-03-29. PMID:36979879. |
adiponectin showed interactions with hub genes, namely mlx interacting protein like (mlxipl), peroxisome proliferator-activated receptor gamma coactivator 1- alpha (ppargc1), peroxisome proliferator-activated receptor gamma (pparg), and adiponectin receptor 1 (adipor1). |
2023-03-29 |
2023-08-14 |
mouse |
| Ziyi Pan, Guoqing Du, Guoyu Li, Dongsheng Wu, Xingyong Chen, Zhaoyu Gen. Apolipoprotein H: a novel regulator of fat accumulation in duck myoblasts. Journal of animal science and technology. vol 64. issue 6. 2023-02-22. PMID:36812035. |
cs2s overexpressing apoh showed enhanced triglyceride (tg) and cholesterol (chol) contents and elevated the mrna and protein expression of akt serine/threonine kinase 1 (akt1), elovl fatty acid elongase 6 (elovl6), and acetyl-coa carboxylase 1 (acc1) while reducing the expression of protein kinase amp-activated catalytic subunit alpha 1 (ampk), peroxisome proliferator activated receptor gamma (pparg), acyl-coa synthetase long chain family member 1 (acsl1), and lipoprotein lipase (lpl). |
2023-02-22 |
2023-08-14 |
Not clear |
| Zhou Lan, Kun Zhang, Jianhui He, Qiong Kang, Wei Meng, Songhua Wan. Pectolinarigenin shows lipid-lowering effects by inhibiting fatty acid biosynthesis in vitro and in vivo. Phytotherapy research : PTR. 2022-11-23. PMID:36415143. |
among them, pparg coactivator 1 beta (ppargc1b) and carnitine palmitoyltransferase 1a (cpt1a) were found to be upregulated, solute carrier family 27 member 1(slc27a1), acetyl-coa carboxylase alpha (acaca), fatty-acid synthase (fasn), 3-hydroxy-3-methylglutaryl-coa reductase (hmgcr), etc. |
2022-11-23 |
2023-08-14 |
Not clear |
| Ruirui Zhu, Duo Guo, Ruirui Li, Ye Feng, Xintong Yang, Qixin Huang, Yuanyu Zheng, Deshun Shi, Jieping Huan. A long non-coding RNA lnc210 promotes adipogenic differentiation of buffalo intramuscular adipocytes. Animal biotechnology. 2022-08-24. PMID:36001396. |
lnc210 overexpression promoted lipid accumulation by upregulating the mrna expression of peroxisome proliferator-activated receptor gamma (pparg) and ccaat enhancer binding protein alpha (c/ebpα) in buffalo intramuscular adipocytes. |
2022-08-24 |
2023-08-14 |
Not clear |
| Xinghui Wang, Mengyao Zhu, Juan J Loor, Qianming Jiang, Yiwei Zhu, Wei Li, Xiliang Du, Yuxiang Song, Wenwen Gao, Lin Lei, Jianguo Wang, Guowen Liu, Xinwei L. Propionate alleviates fatty acid-induced mitochondrial dysfunction, oxidative stress, and apoptosis by upregulating PPARG coactivator 1 alpha in hepatocytes. Journal of dairy science. 2022-02-19. PMID:35181129. |
propionate alleviates fatty acid-induced mitochondrial dysfunction, oxidative stress, and apoptosis by upregulating pparg coactivator 1 alpha in hepatocytes. |
2022-02-19 |
2023-08-13 |
Not clear |
| Yi Zhang, Konosuke Otomaru, Kazunaga Oshima, Yuji Goto, Ichiro Oshima, Susumu Muroya, Mitsue Sano, Sanggun Roh, Takafumi Goto. Maternal Nutrition During Gestation Alters Histochemical Properties, and mRNA and microRNA Expression in Adipose Tissue of Wagyu Fetuses. Frontiers in endocrinology. vol 12. 2022-02-18. PMID:35178028. |
only in sat, low fetuses had more leptin (lep) mrna and tended to have more peroxisome proliferator-activated receptor gamma (pparg) ccaat-enhancer-binding proteins alpha (cebpa) and glucose transporter (glut) 4 mrna(p<0.10). |
2022-02-18 |
2023-08-13 |
cattle |
| Huimin Pei, Shaokang Wu, Lijun Zheng, Hanxun Wang, Xiangrong Zhan. Identification of the active compounds and their mechanisms of medicinal and edible Shanzha based on network pharmacology and molecular docking. Journal of food biochemistry. 2021-11-26. PMID:34825377. |
the key targets were prostaglandin-endoperoxide synthase 2 (ptgs2), serine/threonine-protein kinase mtor (mtor), heat shock protein hsp 90-alpha (hsp90aa1), mitogen-activated protein kinase 1 (mapk1), mapk3, e3 ubiquitin-protein ligase mdm2 (mdm2), receptor tyrosine-protein kinase erbb-2 (erbb2), caspase-3 (casp3), matrix metalloproteinase-9 (mmp9), estrogen receptor (esr1), tumor necrosis factor (tnf), phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (pik3ca), and peroxisome proliferator-activated receptor gamma (pparg), which played the vital roles in tnf, prostate cancer, thyroid hormone, hepatitis b and estrogen signaling pathway. |
2021-11-26 |
2023-08-13 |
Not clear |
| Hanze Guo, Yan Chi, Naiyu Ch. Bioinformatis analysis reveals possible molecular mechanism of PXR on regulating ulcerative colitis. Scientific reports. vol 11. issue 1. 2021-11-22. PMID:33686088. |
finally, carboxylesterase 2 (ces2), atp binding cassette subfamily g member 2 (abcg2), phosphoenolpyruvate carboxykinase (pck1), pparg coactivator 1 alpha (ppargc1a), cytochrome p450 family 2 subfamily b member 6 (cyp2b6) from gene set 1 and c-x-c motif chemokine ligand 8 (cxcl8) from gene set 2 were screened out. |
2021-11-22 |
2023-08-13 |
Not clear |
| Laura C A Galbraith, Ernest Mui, Colin Nixon, Ann Hedley, David Strachan, Gillian MacKay, David Sumpton, Owen J Sansom, Hing Y Leung, Imran Ahma. PPAR-gamma induced AKT3 expression increases levels of mitochondrial biogenesis driving prostate cancer. Oncogene. vol 40. issue 13. 2021-10-18. PMID:33654198. |
akt3 has previously been shown to regulate pparg co-activator 1 alpha (pgc1α) localisation and function through its action on chromosome maintenance region 1 (crm1). |
2021-10-18 |
2023-08-13 |
Not clear |
| Jing Ma, Yue Ren, Jia-Ning Zhang, Li Lin, Yan-Ling Zhan. [Analysis on targets of regulating Qi and activating blood based on activity spectrum of targets]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 15. 2021-09-03. PMID:34472274. |
the enrichment analysis of topology, go and kegg showed that tcm for activating blood circulation mainly exerted its anti-inflammatory, neuroprotective and angiogenic effects on signaling cascade pathway mediated by vegf/vegfr2, erk signaling pathway, calcium signaling pathway and pi3 k-akt signaling pathway, and the key targets included mitogen activated protein kinases 3(mapk3), proto-oncogene tyrosine-protein kinase src(src), mitogen activated protein kinases 1(mapk1), epidermal growth factor receptor(egfr), phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(pik3 ca), peroxisome proliferators-activated receptor gamma(pparg), nitric oxide synthase 3(nos3), prostaglandin g/h synthetase 2(ptgs2), matrix metalloproteinase-9(mmp9), and vascular endothelial growth factor a(vegfa). |
2021-09-03 |
2023-08-13 |
Not clear |
| Honglei Wu, Bin Liu, Zhaosheng Chen, Guangchun Li, Zhen Zhan. MSC-induced lncRNA HCP5 drove fatty acid oxidation through miR-3619-5p/AMPK/PGC1α/CEBPB axis to promote stemness and chemo-resistance of gastric cancer. Cell death & disease. vol 11. issue 4. 2021-04-08. PMID:32300102. |
mechanistically, hcp5 sequestered mir-3619-5p and upregulated pparg coactivator 1 alpha (ppargc1a), increasing transcription complex peroxisome proliferator activated receptor (ppar) coactivator-1α (pgc1α)/cebpb and transcriptionally inducing carnitine palmitoyltransferase 1 (cpt1), which prompted the fatty acid oxidation (fao) in gc cells. |
2021-04-08 |
2023-08-13 |
Not clear |
| Jing Luo, Weian Zhao, Yi Gan, Bo Pan, Lingjuan Liu, Zhenguo Liu, Jie Tia. Cardiac Troponin I R193H Mutation Is Associated with Mitochondrial Damage in Cardiomyocytes. DNA and cell biology. vol 40. issue 2. 2021-02-26. PMID:33465007. |
western blot analysis demonstrated that expressions of mitochondria-related genes, including nd5 (ubiquinone oxidoreductase chain 5), lrpprc (a leucine-rich protein of pentatricopeptide repeat family), and pgc-1α (pparg co-activator 1 alpha), were significantly downregulated in r193h mutation cardiomyocytes compared with the control. |
2021-02-26 |
2023-08-13 |
mouse |
| Letícia Fracaro, Alexandra C Senegaglia, Roberto H Herai, Amanda Leitolis, Lidiane M Boldrini-Leite, Carmen L K Rebelatto, Paul J Travers, Paulo R S Brofman, Alejandro Corre. The Expression Profile of Dental Pulp-Derived Stromal Cells Supports Their Limited Capacity to Differentiate into Adipogenic Cells. International journal of molecular sciences. vol 21. issue 8. 2021-02-08. PMID:32326648. |
while dpscs differentiated readily along osteogenic and chondrogenic pathways, after 21 days in two different types of adipogenic induction media, dpscs cultures did not contain lipid vacuoles and had low expression levels of the adipogenic genes proliferator-activated receptor gamma (pparg), lipoprotein lipase (lpl) and ccaat/enhancer-binding protein alpha (cebpa). |
2021-02-08 |
2023-08-13 |
Not clear |
| Wei Zhang, Qiangqiang Chen, Liaoyi Xu, Jianfeng Cai, Jinzhi Zhan. The potential role of PSMA6 in modulating fat deposition in pigs by promoting preadipocyte proliferation and differentiation. Gene. vol 769. 2021-01-29. PMID:33096182. |
it was also found that the transcription factors ccaat/enhancer-binding protein alpha (cebpa) and peroxisome proliferator-activated receptor gamma (pparg), as well as the key genes related to adipogenesis, were upregulated, while the genes related to fat oxidation were significantly downregulated, which indicated that the psma6 gene could stimulate the differentiation of preadipocytes. |
2021-01-29 |
2023-08-13 |
Not clear |
| K Deng, C Ren, Y Fan, Z Liu, G Zhang, Y Zhang, P You, F Wan. miR-27a is an important adipogenesis regulator associated with differential lipid accumulation between intramuscular and subcutaneous adipose tissues of sheep. Domestic animal endocrinology. vol 71. 2021-01-06. PMID:31731253. |
however, the expression of peroxisome proliferator-activated receptor gamma (pparg) and retinoid x receptor alpha (rxr alpha) in im adipose tissue was significantly lower than that in sc adipose tissue. |
2021-01-06 |
2023-08-13 |
Not clear |