| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanzhang Xia, Yinghui Wu, Yuhao Gong, Caichun Yue, Linfeng Tao, Tianwen Xin, Cong Shen, Yue Zhu, Minghong Shen, Jun She. Brachyury Promotes Extracellular Matrix Synthesis through Transcriptional Regulation of Smad3 in Nucleus Pulposus. American journal of physiology. Cell physiology. 2024-05-01. PMID:38690917. |
brachyury promotes extracellular matrix synthesis through transcriptional regulation of smad3 in nucleus pulposus. |
2024-05-01 |
2024-05-04 |
human |
| Marta Halasa, Ahmed Uosef, Henry V Ubelaker, Arijita Subuddhi, Krupa R Mysore, Jacek Z Kubiak, Rafik M Ghobrial, Jarek Wosik, Malgorzata Klo. Gadolinium retention effect on macrophages - a potential cause of MRI contrast agent Dotarem toxicity. Cell and tissue research. 2024-04-16. PMID:38625373. |
gadolinium retention for 7 days decreased macrophage adhesion and motility and dysregulated the expression of adhesion and fibrotic pathway-related proteins such as notch1 and its ligand jagged1, adhesion/migration-related proteins pak1 and shp1, immune response-related transcription factors smad3 and tcf19, and chemokines cxcl10 and cxcl13, and dysregulated the mrna expression of fibrosis-related genes involved in extracellular matrix (ecm) synthesis, such as col6a1, fibronectin, mmp9, and mmp12. |
2024-04-16 |
2024-04-18 |
Not clear |
| Xingxing Zhu, Jiahui Lu, Jia Rao, Dongqing Ru, Mengru Gao, Dongyan Shi, Kelei Cao, Shuang Wen, Chunsun Dai, Xuerong Wang, Wenli Mi, Lixin Liu, Hong Zho. Crosstalk between ST2 and TGF-β Receptor Signaling Promotes Renal Fibrosis. The American journal of pathology. 2023-05-26. PMID:37236504. |
in hk-2 cells, il-33 promotes the phosphorylation of the tgf-β receptor, smad2, and smad3, and the production of extracellular matrix (ecm), with reduced expression of e-cadherin. |
2023-05-26 |
2023-08-14 |
mouse |
| Ying-Ying Zhang, Rui-Zhi Tan, Ying Yu, Yang-Yang Niu, Chen Y. LncRNA GAS5 protects against TGF-β-induced renal fibrosis via the Smad3/miRNA-142-5p axis. American journal of physiology. Renal physiology. vol 321. issue 4. 2021-11-08. PMID:34486400. |
taken together, our results uncovered a lncrna/mirna competing endogenous rna network-based mechanism that modulates extracellular matrix formation and cell apoptosis via the smad3 pathway. |
2021-11-08 |
2023-08-13 |
mouse |
| Sung Joon Park, Hyunsu Choi, Ji Heon Kim, Choung-Soo Ki. Antifibrotic effects of eupatilin on TGF-β1-treated human vocal fold fibroblasts. PloS one. vol 16. issue 3. 2021-10-12. PMID:33765087. |
western blotting was used to measure the expression of alpha-smooth muscle actin during myofibroblast differentiation, fibronectin (fn), collagen type i (col i), and collagen type iii (col iii) extracellular matrix proteins, and smad2, smad3, and p38 in the fibrotic pathway. |
2021-10-12 |
2023-08-13 |
human |
| Qiufen Xun, Jiulong Kuang, Qing Yang, Wei Wang, Guofeng Zh. Glucocorticoid induced transcript 1 represses airway remodeling of asthmatic mouse via inhibiting IL-13/periostin/TGF-β1 signaling. International immunopharmacology. vol 97. 2021-07-30. PMID:33895479. |
importantly, upregulation of glcci1 suppressed the expression of il-13, periostin and tgf-β1, phosphorylation of smad2 and smad3, and extracellular matrix (ecm) deposition-related proteins expression. |
2021-07-30 |
2023-08-13 |
mouse |
| Bo Li, Yue Zhou, Jing Chen, Tingting Wang, Zhijuan Li, Yili Fu, Aixia Zhai, Changlong B. Long noncoding RNA H19 acts as a miR-29b sponge to promote wound healing in diabetic foot ulcer. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 1. 2021-06-15. PMID:33174326. |
silencing of lncrna h19 led to inhibited proliferation, migration, and enhanced apoptosis of fibroblasts, accompanied by downregulated fbn1 but upregulated mir-29b, which diminished the expression of tgf-β1, smad3, fn, and col-1 and reduced extracellular matrix accumulation. |
2021-06-15 |
2023-08-13 |
mouse |
| Xin Chen, Wansheng Peng, Rui Zhou, Zhen Zhang, Jiali X. Montelukast improves bronchopulmonary dysplasia by inhibiting epithelial‑mesenchymal transition via inactivating the TGF‑β1/Smads signaling pathway. Molecular medicine reports. vol 22. issue 3. 2021-04-26. PMID:32705209. |
western blotting and reverse transcription‑quantitative pcr were performed to measure the expression levels of surfactant protein c (sp‑c), e‑cadherin, n‑cadherin, vimentin, collagen i (col i), matrix metallopeptidase (mmp)1/3, transforming growth factor (tgf)‑β1 and smad3. |
2021-04-26 |
2023-08-13 |
rat |
| Mercedes N Munkonda, Shareef Akbari, Chloe Landry, Suzy Sun, Fengxia Xiao, Maddison Turner, Chet E Holterman, Rania Nasrallah, Richard L Hébert, Christopher R J Kennedy, Dylan Burge. Podocyte-derived microparticles promote proximal tubule fibrotic signaling via p38 MAPK and CD36. Journal of extracellular vesicles. vol 7. issue 1. 2020-10-01. PMID:29435202. |
treatment with podocyte mps increased p38 and smad3 phosphorylation and expression of the extracellular matrix (ecm) proteins fibronectin and collagen type iv. |
2020-10-01 |
2023-08-13 |
human |
| Weihao Li, Shurong Zhao, Hefeng Yang, Chao Zhang, Qiang Kang, Jie Deng, Yanhua Xu, Yu Ding, Song L. Potential Novel Prediction of TMJ-OA: MiR-140-5p Regulates Inflammation Through Smad/TGF-β Signaling. Frontiers in pharmacology. vol 10. 2020-09-30. PMID:30728776. |
the expression of matrix metallopeptidase (mmp)-13, mir-140-5p, nuclear factor (nf)-kb, smad3 and transforming growth factor (tgf)-β3 were examined by western blotting or quantitative reverse-transcription polymerase chain reaction (qrt-pcr). |
2020-09-30 |
2023-08-13 |
mouse |
| Yong-Ke You, Qi Luo, Wei-Feng Wu, Jiao-Jiao Zhang, Hong-Jian Zhu, Lixing Lao, Hui Y Lan, Hai-Yong Chen, Yong-Xian Chen. Petchiether A attenuates obstructive nephropathy by suppressing TGF-β/Smad3 and NF-κB signalling. Journal of cellular and molecular medicine. vol 23. issue 8. 2020-08-25. PMID:31211499. |
an in vivo study revealed that peta protected against renal inflammation and fibrosis by reducing the infiltration of macrophages, inhibiting the expression of proinflammatory cytokines (interleukin-1β and tumour necrosis factor-α) and reducing extracellular matrix deposition (α-smooth muscle actin, collagen i and fibronectin) in the obstructed kidney of uuo mice; these changes were associated with suppression of smad3 and nf-κb p65 phosphorylation. |
2020-08-25 |
2023-08-13 |
mouse |
| Yuanyuan Wang, Xiaohuan Zhang, Yanwen Mao, Luqun Liang, Lingling Liu, Wei Peng, Huiming Liu, Ying Xiao, Yingying Zhang, Fan Zhang, Mingjun Shi, Lirong Liu, Bing Gu. Smad2 and Smad3 play antagonistic roles in high glucose-induced renal tubular fibrosis via the regulation of SnoN. Experimental and molecular pathology. vol 113. 2020-07-20. PMID:31917288. |
diabetic nephropathy (dn) is a serious microvascular complication of diabetes mellitus.the main pathological features of dn include glomerular sclerosis and renal tubular interstitial fibrosis, which results in epithelial mesenchymal transition (emt) and excessive extracellular matrix (ecm) deposition.transforming growth factor-β1(tgf-β1) is a critical factor that regulates the manifestation of renal fibrosis.smad2 and smad3 are the main downstream of the tgf-β1 pathway. |
2020-07-20 |
2023-08-13 |
rat |
| He Li, Liu-Qing Qian, Xue Chen, Ning-Yu Zhang, Shan-Shan Lei, Bo Li, Gui-Yuan Lyu, Su-Hong Che. [Preventive effect and mechanism of ultrafine powder of Dendrobium candidum on photoaging model mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 21. 2020-01-14. PMID:31872664. |
the skin wrinkle grade,elastic parameters,skin microcirculation blood flow,skin structure and pathological changes(skin thickness,skin collagen fiber,elastic fiber) were observed,the skin transforming growth factor-β1(tgf-β1),smad3 levels were determined,and the type Ⅰ and type Ⅲ collagen,matrix metalloproteinase-1(mmp-1),activated protein-1(ap-1),vegf expression were detected. |
2020-01-14 |
2023-08-13 |
mouse |
| Rui Yang, Qiang Jia, Shan-Feng Ma, Ya Wang, Shomaila Mehmood, Yan Che. Exogenous H2S mitigates myocardial fibrosis in diabetic rats through suppression of the canonical Wnt pathway. International journal of molecular medicine. vol 44. issue 2. 2019-12-23. PMID:31198980. |
matrix metalloprotease (mmp)‑2, tissue inhibitor of metalloproteinase (timp)‑2, collagens, and canonical wnt and transforming growth factor (tgf)‑β1/smad family member 3 (smad3) pathway‑related proteins were assessed by western blotting. |
2019-12-23 |
2023-08-13 |
rat |
| Hiroyuki Ono, Hideharu Abe, Akiko Sakurai, Arisa Ochi, Tatsuya Tominaga, Masanori Tamaki, Seiji Kishi, Taichi Murakami, Kojiro Nagai, Masayuki Kohashi, Toshio Do. Novel Interplay Between Smad1 and Smad3 Phosphorylation via AGE Regulates the Progression of Diabetic Nephropathy. Scientific reports. vol 8. issue 1. 2019-11-25. PMID:30002389. |
extracellular matrix (ecm) protein overexpression and smad1 activation were observed in the glomeruli of db/db mice but were suppressed in the glomeruli of smad3 |
2019-11-25 |
2023-08-13 |
mouse |
| Tomislav Sarenac, Martin Trapecar, Lidija Gradisnik, Marjan Slak Rupnik, Dusica Paho. Single-cell analysis reveals IGF-1 potentiation of inhibition of the TGF-β/Smad pathway of fibrosis in human keratocytes in vitro. Scientific reports. vol 6. 2019-11-20. PMID:27687492. |
igf-1 alone decreased smad3 nuclearization and increased aldehyde dehydrogenase 3a1 expression, with favorable extracellular matrix proteoglycan composition. |
2019-11-20 |
2023-08-13 |
human |
| T Xu, Y X Wu, J X Sun, F C Wang, Z Q Cui, X H X. The role of miR-145 in promoting the fibrosis of pulmonary fibroblasts. Journal of biological regulators and homeostatic agents. vol 33. issue 5. 2019-11-06. PMID:31637903. |
in addition, the qpcr (quantitative real-time polymerase chain reaction) and western blot were applied to detect the mrna and protein expressions of mir-145, tgf-β1 (transforming growth factor beta 1), smad3, smad4, mmp2 (matrix metalloproteinase 2), fn1 (fibronectin 1), eln (elastin) and coli α1 (collagen type i alpha 1) signaling molecules in tgf-β/smad fibrosis pathway. |
2019-11-06 |
2023-08-13 |
Not clear |
| Matthew C Altman, Michelle A Gill, Elizabeth Whalen, Denise C Babineau, Baomei Shao, Andrew H Liu, Brett Jepson, Rebecca S Gruchalla, George T O'Connor, Jacqueline A Pongracic, Carolyn M Kercsmar, Gurjit K Khurana Hershey, Edward M Zoratti, Christine C Johnson, Stephen J Teach, Meyer Kattan, Leonard B Bacharier, Avraham Beigelman, Steve M Sigelman, Scott Presnell, James E Gern, Peter J Gergen, Lisa M Wheatley, Alkis Togias, William W Busse, Daniel J Jackso. Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children. Nature immunology. vol 20. issue 5. 2019-04-29. PMID:30962590. |
specifically, in both virus-associated and nonviral exacerbations, we demonstrate a set of core exacerbation modules, among which epithelial-associated smad3 signaling is upregulated and lymphocyte response pathways are downregulated early in exacerbation, followed by later upregulation of effector pathways including epidermal growth factor receptor signaling, extracellular matrix production, mucus hypersecretion, and eosinophil activation. |
2019-04-29 |
2023-08-13 |
Not clear |
| Nguyen P T Huynh, Jonathan M Brunger, Catherine C Gloss, Franklin T Moutos, Charles A Gersbach, Farshid Guila. Genetic Engineering of Mesenchymal Stem Cells for Differential Matrix Deposition on 3D Woven Scaffolds. Tissue engineering. Part A. vol 24. issue 19-20. 2019-04-08. PMID:29756533. |
this differential induction was performed by culturing cells on engineered three-dimensionally woven poly(ɛ-caprolactone) (pcl) scaffolds in a chondrogenic environment for cartilage-like matrix production while inhibiting tgfβ3 signaling through mothers against dpp homolog 3 (smad3) knockdown, in combination with overexpressing runx2, to achieve mineralization. |
2019-04-08 |
2023-08-13 |
human |
| Kais Hussein, Angelika Stucki-Koch, Hans Kreip. Profile of fibrosis-related gene transcripts and megakaryocytic changes in the bone marrow of myelodysplastic syndromes with fibrosis. Annals of hematology. vol 97. issue 11. 2018-10-09. PMID:29961094. |
mds-mf showed increased expression of thrombospondin 1 (thbs1), timp metallopeptidase inhibitor 1 (timp1), transforming growth factor beta 1 (tgfb1), matrix metallopeptidases 2 and 14 (mmp2, mmp14), smad family members 3 and 4 (smad3, smad4), and mir-146b. |
2018-10-09 |
2023-08-13 |
Not clear |