| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sun Chenchen, Qian Xueqian, Lu Yahui, Yuan Yi, Zhang Hui, Bai Lanning, Cheng Min, Han Yangyan. STAT3 mediates ECM stiffness-dependent progression in ovarian cancer. Molecular and cellular biochemistry. 2024-04-16. PMID:38625514. |
based on our previous results combined with the crucial regulatory role of stat3 in the malignant progression of various cancer types, we want to investigate the relationship between stat3 and matrix stiffness in ovarian cancer and further explore the potential mechanisms. |
2024-04-16 |
2024-04-18 |
mouse |
| Sun Chenchen, Qian Xueqian, Lu Yahui, Yuan Yi, Zhang Hui, Bai Lanning, Cheng Min, Han Yangyan. STAT3 mediates ECM stiffness-dependent progression in ovarian cancer. Molecular and cellular biochemistry. 2024-04-16. PMID:38625514. |
western blotting, qrt-pcr, flow cytometry, ihc, edu assays, and tem were used to evaluate the effect of stat3 in vitro under different matrix stiffnesses. |
2024-04-16 |
2024-04-18 |
mouse |
| Sun Chenchen, Qian Xueqian, Lu Yahui, Yuan Yi, Zhang Hui, Bai Lanning, Cheng Min, Han Yangyan. STAT3 mediates ECM stiffness-dependent progression in ovarian cancer. Molecular and cellular biochemistry. 2024-04-16. PMID:38625514. |
the novel findings suggest that stat3, a potential therapeutic target for clinical diagnosis and treatment, is a mechanically responsive gene that responds to matrix stiffness, particularly regulation in migration and adhesion in the progression of ovarian cancer. |
2024-04-16 |
2024-04-18 |
mouse |
| Xuanhong Jin, Liangkun You, Jincheng Qiao, Weidong Han, Hongming Pa. Autophagy in colitis-associated colon cancer: exploring its potential role in reducing initiation and preventing IBD-Related CAC development. Autophagy. vol 20. issue 2. 2024-01-25. PMID:37723664. |
a. muciniphila: akkermansia muciniphila; aiec: adherent invasive escherichia coli; aom/dss: azoxymethane-dextran sodium sulfate; atg: autophagy related; becn1: beclin1, autophagy related; cac: colitis-associated colon cancer; ccdc50: coiled-coil domain containing 50; cldn2: claudin 2; copec: colibactin-producing escherichia coli; crc: colorectal cancer; damps: danger/damage-associated molecular patterns; dc: dendritic cell; dss: dextran sulfate sodium; dtp: drug-resistant persistent; er: endoplasmic reticulum; ern1/ire1α: endoplasmic reticulum to nucleus signaling 1; ibd: inflammatory bowel disease; iecs: intestinal epithelial cells; ikk: ikappab kinase; il: interleukin; irgm1: immunity-related gtpase family m member 1; isc: intestinal stem cell; lps: lipopolysaccharide; map1lc3/lc3: microtubule-associated protein 1 light chain 3; mapk: mitogen-activated protein kinase; mdp: muramyl dipeptide; melk: maternal embryonic leucine zipper kinase; mhc: major histocompatibility complex; mirna: microrna; mtor: mechanistic target of rapamycin kinase; nlrp3: nlr family, pyrin domain containing 3; nod2: nucleotide-binding oligomerization domain containing 2; nrbf2: nuclear receptor binding factor 2; pamps: pathogen-associated molecular patterns; pi3k: class i phosphoinositide 3-kinase; ptdins3k: class iii phosphatidylinositol 3-kinase; pycard/asc: pyd and card domain containing; ralgapa2/ralgapα2: ral gtpase activating protein protein, alpha subunit 2 (catalytic); ripk2/card3: receptor (tnfrsf)-interacting serine-threonine kinase 2; ripk3: receptor-interacting serine-threonine kinase 3; ros: reactive oxygen species; scrc: sporadic colorectal cancer; smarca4/brg1: swi/snf related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; sqstm1: sequestosome 1; stat3: signal transducer and activator of transcription 3; tnf/tnfa: tumor necrosis factor; ulk1: unc-51 like autophagy activating kinase 1; upr: unfolded protein response; wt: wild-type. |
2024-01-25 |
2024-01-27 |
Not clear |
| Da-He Qi, Hua Ma, Yuan-Yuan Chen, Ke-Xin Wang, Meng-Meng Ding, Yun-Long Hao, Ye Guo, Ling-Bo Kon. [Research progress in mechanism of puerarin in treating vascular dementia]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 48. issue 22. 2023-12-19. PMID:38114205. |
the pathways of action include activating nuclear factor erythroid 2-related factor 2(nrf2)/antioxidant response element(are), vascular endothelial growth factor(vegf), extracellular regulated protein kinases(erk), phosphatidylinositol-3-kinase(pi3k)/protein kinase b(akt), janus-activating kinase 2(jak2)/signal transducer and activator of transcription 3(stat3), amp-activated protein kinase(ampk), as well as inhibiting the tumor necrosis factor α(tnf-α), transient receptor potential melastatin 2(trpm2)/n-methyl-d-aspartate receptor(nmdar), p38 mitogen-activated protein kinase(p38 mapk), toll-like receptor 4(tlr4)/nuclear factor-kappab(nf-κb), early growth response 1(egr-1), and matrix metalloproteinase 9(mmp-9). |
2023-12-19 |
2023-12-23 |
Not clear |
| Suryaa Manoharan, Shreejit Saha, Krishnasanthiya Murugesan, Aksayakeerthana Santhakumar, Ekambaram Peruma. Natural bioactive compounds and STAT3 against hepatocellular carcinoma: An update. Life sciences. 2023-12-16. PMID:38103726. |
further, through stat3 inhibition, terpenes downregulate matrix metalloprotease 2 (mmp2), matrix metalloprotease 9 (mmp9) and vascular endothelial growth factor (vegf), modulating metastasis. |
2023-12-16 |
2023-12-21 |
Not clear |
| Susan Farmand, Vicky Sender, Jens Karlsson, Padryk Merkl, Staffan Normark, Birgitta Henriques-Normar. STAT3 Deficiency Alters the Macrophage Activation Pattern and Enhances Matrix Metalloproteinase 9 Expression during Staphylococcal Pneumonia. Journal of immunology (Baltimore, Md. : 1950). 2023-11-20. PMID:37982695. |
stat3 deficiency alters the macrophage activation pattern and enhances matrix metalloproteinase 9 expression during staphylococcal pneumonia. |
2023-11-20 |
2023-11-29 |
mouse |
| Susan Farmand, Vicky Sender, Jens Karlsson, Padryk Merkl, Staffan Normark, Birgitta Henriques-Normar. STAT3 Deficiency Alters the Macrophage Activation Pattern and Enhances Matrix Metalloproteinase 9 Expression during Staphylococcal Pneumonia. Journal of immunology (Baltimore, Md. : 1950). 2023-11-20. PMID:37982695. |
matrix metalloproteinase 9 was upregulated in staphylococcus-treated stat3-deficient bmdm and in lung tissues of stat3 knockout mice infected with s. aureus. |
2023-11-20 |
2023-11-29 |
mouse |
| Junyin Tan, Ronghao Fen. A pan-cancer analysis of STAT3 expression and genetic alterations in human tumors. Open medicine (Warsaw, Poland). vol 18. issue 1. 2023-09-19. PMID:37724127. |
the results of the ime analysis revealed that the immune and matrix scores of lggs were positively correlated with the expression of stat3 ( |
2023-09-19 |
2023-10-07 |
human |
| Jin Song, Junfeng Du, Lili Han, Xue Lin, Cibo Fan, Gang Che. The Effect of Metformin on Triple-Negative Breast Cancer Cells and Nude Mice. Alternative therapies in health and medicine. 2023-08-26. PMID:37632970. |
through the use of both enzyme-linked immunosorbent assay and real-time fluorescence quantification, it was ascertained that the expression of signal transducer and activator of transcription 3 (stat3) saw significant augmentation, while expressions of matrix metallopeptidase-2 (mmp-2), matrix metallopeptidase-9 (mmp-9), interleukin-6 (il-6), and interleukin-7 (il-7) decreased markedly. |
2023-08-26 |
2023-09-07 |
mouse |
| Shipra Kanti Jena, Shreya Das, Shreeta Chakraborty, Rupasri Ai. Molecular determinants of epithelial mesenchymal transition in mouse placenta and trophoblast stem cell. Scientific reports. vol 13. issue 1. 2023-07-06. PMID:37414855. |
further validation of array results using real time pcr and western blot analysis showed significant decrease in emt-associated genes that included (a) transcription factors (snai2, zeb1, stat3 and foxc2), (b) extracellular matrix and cell adhesion related genes (bmp1, itga5, vcan and col3a1), (c) migration and motility- associated genes (vim, msn and fn1) and (d) differentiation and development related genes (wnt5b, jag1 and cleaved notch-1) on e9.5. |
2023-07-06 |
2023-08-14 |
mouse |
| Ping-Chih Hsu, Jhy-Ming Li, Cheng-Ta Yan. Forced Overexpression of Signal Transducer and Activator of Transcription 3 (STAT3) Activates Yes-Associated Protein (YAP) Expression and Increases the Invasion and Proliferation Abilities of Small Cell Lung Cancer (SCLC) Cells. Biomedicines. vol 10. issue 7. 2023-03-08. PMID:35885009. |
we showed that stat3 overexpression promoted emt (epithelial−mesenchymal transition) with increased matrix metalloproteinase (mmp)-2 and mmp9 expression. |
2023-03-08 |
2023-08-16 |
mouse |
| Ying Shen, Jinling Ning, Lu Zhao, Wei Liu, Ting Wang, Jie Yu, Yiqiang Wan. Matrix remodeling associated 7 proteins promote cutaneous wound healing through vimentin in coordinating fibroblast functions. Inflammation and regeneration. vol 43. issue 1. 2023-01-16. PMID:36647132. |
quantitative pcr indicated that lack of mxra7 impaired the expression of several extracellular matrix genes (e.g., mmp-2) and inhibited signaling pathways (e.g., stat3) in healing ear tissues. |
2023-01-16 |
2023-08-14 |
mouse |
| Bowen Yang, Qiuwen Zhu, Xiaodong Wang, Jingxin Mao, Shuqing Zho. Using network pharmacology and molecular docking verification to explore the mechanism of ursolic acid in the treatment of osteoporosis. Medicine. vol 101. issue 49. 2023-01-10. PMID:36626454. |
a total of 24 core target genes were obtained, mainly including tumor protein p53 (tp53), vascular endothelial growth factor a (vegfa), interleukin-6 (il6), tumor necrosis factor (tnf), caspase3 (casp3), matrix metallo protein (mmp9), transcription factor ap-1 (jun), activator of transcription 3 (stat3), mitogen-activated protein kinase 8 (mapk8), and prostaglandin endoperoxidase 2 (ptgs2), respectively. |
2023-01-10 |
2023-08-14 |
Not clear |
| Qionghong Xie, Min Zhang, Xiaoyi Mao, Mingyue Xu, Shaojun Liu, Da Shang, Yunyu Xu, Ruiying Chen, Yi Guan, Xinzhong Huang, Roy Zent, Ambra Pozzi, Chuan-Ming Ha. Matrix protein Tenascin-C promotes kidney fibrosis via STAT3 activation in response to tubular injury. Cell death & disease. vol 13. issue 12. 2022-12-15. PMID:36522320. |
matrix protein tenascin-c promotes kidney fibrosis via stat3 activation in response to tubular injury. |
2022-12-15 |
2023-08-14 |
mouse |
| Xinyi Gong, Siyuan Sun, Yiling Yang, Xiangru Huang, Xin Gao, Anting Jin, Hongyuan Xu, Xijun Wang, Yuanqi Liu, Jingyi Liu, Qinggang Dai, Lingyong Jian. Osteoblastic STAT3 is Crucial for Orthodontic Force Driving Alveolar Bone Remodeling and Tooth Movement. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2022-11-12. PMID:36370067. |
according to rna-seq analysis of stat3-deleted bmscs under mechanical force, matrix metalloproteinase 3 (mmp3) was screened and predicted to be a downstream target of stat3. |
2022-11-12 |
2023-08-14 |
Not clear |
| Qian Liu, Jinli Ding, Qingzhen Xi. Regulatory Effects of Fyn on Trophoblast Cell Behaviors and Function. BioMed research international. vol 2022. 2022-11-04. PMID:36330453. |
the production of primary inflammatory cytokines, hla-g and active matrix metallopeptidase (mmp) 2/9, and the phosphorylation of erk1/2 and stat3 were evaluated by elisa, western blot, or gelatin zymography. |
2022-11-04 |
2023-08-14 |
human |
| Tadashi Yasuda, Shigeo Hara, Shinnosuke Yamashita, Sadaki Mitsuzawa, Yoshihiro Tsukamoto, Hisataka Takeuchi, Satoshi Ota, Eijiro Onish. Activation of STAT3 (signal transducer and activator of transcription 3) in synovial tissues from the hip joint in the early stage of rapidly destructive coxopathy. Biomedical research (Tokyo, Japan). vol 43. issue 5. 2022-10-16. PMID:36244795. |
interleukin-6 signaling activates signal transducer and activator of transcription 3 (stat3), resulting in matrix metalloproteinase-3 (mmp-3) production. |
2022-10-16 |
2023-08-14 |
Not clear |
| Lin Li, Mengxing Zhang, Tiantian Liu, Jing Li, Shili Sun, Junjie Chen, Zhenmi Liu, Zhirong Zhang, Ling Zhan. Quercetin-ferrum nanoparticles enhance photothermal therapy by modulating the tumor immunosuppressive microenvironment. Acta biomaterialia. 2022-10-15. PMID:36243377. |
the released quercetin from qfn could reduce programmed death ligand 1 (pd-l1) in tumor cells by inhibiting the phosphorylation of jak2 and stat3, and reshape extracellular matrix (ecm) by down-regulating α-sma |
2022-10-15 |
2023-08-14 |
Not clear |
| Beenu Moza Jalali, Pawel Likszo, Karolina Lukasi. STAT3 in porcine endometrium during early pregnancy induces changes in extracellular matrix components and promotes angiogenesis. Biology of reproduction. 2022-08-17. PMID:35977090. |
stat3 in porcine endometrium during early pregnancy induces changes in extracellular matrix components and promotes angiogenesis. |
2022-08-17 |
2023-08-14 |
mouse |