| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maximillian N J Woodall, Ana-Maria Cujba, Kaylee B Worlock, Katie-Marie Case, Tereza Masonou, Masahiro Yoshida, Krzysztof Polanski, Ni Huang, Rik G H Lindeboom, Lira Mamanova, Liam Bolt, Laura Richardson, Batuhan Cakir, Samuel Ellis, Machaela Palor, Thomas Burgoyne, Andreia Pinto, Dale Moulding, Timothy D McHugh, Aarash Saleh, Eliz Kilich, Puja Mehta, Chris O'Callaghan, Jie Zhou, Wendy Barclay, Paolo DeCoppi, Colin R Butler, Mario Cortina-Borja, Heloise Vinette, Sunando Roy, Judith Breuer, Rachel C Chambers, Wendy E Heywood, Kevin Mills, Robert E Hynds, Sarah A Teichmann, Kerstin B Meyer, Marko Z Nikolić, Claire M Smit. Age-specific nasal epithelial responses to SARS-CoV-2 infection. Nature microbiology. 2024-04-15. PMID:38622380. |
we show that cell tropism of sars-cov-2, and expression of ace2 and tmprss2 in nasal epithelial cell subtypes, differ between age groups. |
2024-04-15 |
2024-04-18 |
Not clear |
| Paul Feinstei. Rapid Degradation of the Human ACE2 Receptor Upon Binding and Internalization of SARS-Cov-2-Spike-RBD Protein. bioRxiv : the preprint server for biology. 2024-03-18. PMID:38496410. |
it is widely accepted that the sars-cov-2 betacoronavirus infects humans through binding the human angiotensin receptor 2 (ace2) that lines the nasal cavity and lungs, followed by import into a cell utilizing the transmembrane protease, serine 2 (tmprss2) cofactor. |
2024-03-18 |
2024-03-20 |
human |
| Ke Xu, Xingyi Shi, Christopher Husted, Rui Hong, Yichen Wang, Boting Ning, Travis B Sullivan, Kimberly M Rieger-Christ, Fenghai Duan, Helga Marques, Adam C Gower, Xiaohui Xiao, Hanqiao Liu, Gang Liu, Grant Duclos, Michael Platt, Avrum E Spira, Sarah A Mazzilli, Ehab Billatos, Marc E Lenburg, Joshua D Campbell, Jennifer E Bean. Smoking modulates different secretory subpopulations expressing SARS-CoV-2 entry genes in the nasal and bronchial airways. Scientific reports. vol 12. issue 1. 2022-10-28. PMID:36307504. |
the similarities and differences of ve gene expression (ace2, tmprss2, and ctsl) across nasal and bronchial compartments have not been fully characterized using matched samples from large cohorts. |
2022-10-28 |
2023-08-14 |
Not clear |
| Alex J B Kreutzberger, Anwesha Sanyal, Anand Saminathan, Louis-Marie Bloyet, Spencer Stumpf, Zhuoming Liu, Ravi Ojha, Markku T Patjas, Ahmed Geneid, Gustavo Scanavachi, Catherine A Doyle, Elliott Somerville, Ricardo Bango Da Cunha Correira, Giuseppe Di Caprio, Sanna Toppila-Salmi, Antti Mäkitie, Volker Kiessling, Olli Vapalahti, Sean P J Whelan, Giuseppe Balistreri, Tom Kirchhause. Tracking infectious entry routes of SARS-CoV-2. bioRxiv : the preprint server for biology. 2022-06-15. PMID:35702155. |
we define a key role of an acidic environment for successful infection, found in endosomal compartments and at the surface of tmprss2 expressing cells in the acidic milieu of the nasal cavity. |
2022-06-15 |
2023-08-14 |
Not clear |
| Mohammad Rubayet Hasan, Muneera Naseer Ahmad, Soha Roger Dargham, Hatem Zayed, Alaa Al Hashemi, Nonhlanhla Ngwabi, Andres Perez Lopez, Simon Dobson, Laith Jamal Abu Raddad, Patrick Tan. Nasopharyngeal Expression of Angiotensin-Converting Enzyme 2 and Transmembrane Serine Protease 2 in Children within SARS-CoV-2-Infected Family Clusters. Microbiology spectrum. 2021-11-09. PMID:34730438. |
lower levels of angiotensin-converting enzyme 2 (ace2) and transmembrane serine protease 2 (tmprss2) in the nasal epithelium of children may be related to a lower incidence of severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infection, compared to adults. |
2021-11-09 |
2023-08-13 |
Not clear |
| Jeong-Yeon Ji, Ara Jo, Jina Won, Chan Hee Gil, Haeun Shin, Sujin Kim, Yung Jin Jeon, Hyun Jik Ki. The nasal symbiont iScience. vol 24. issue 10. 2021-10-23. PMID:34604720. |
the nasal symbiont emerging evidence indicates that severe acute respiratory syndrome-related coronavirus-2 (sars-cov-2) is transmitted through the human nasal mucosa via the principal entry factors angiotensin-converting enzyme 2 (ace2) and transmembrane serine protease 2 (tmprss2), which are highly expressed in the nasal epithelium. |
2021-10-23 |
2023-08-13 |
human |
| Yuan Hou, Yadi Zhou, Michaela U Gack, Justin D Lathia, Asha Kallianpur, Reena Mehra, Timothy A Chan, Jae U Jung, Lara Jehi, Charis Eng, Feixiong Chen. Multimodal single-cell omics analysis identifies epithelium-immune cell interactions and immune vulnerability associated with sex differences in COVID-19. Signal transduction and targeted therapy. vol 6. issue 1. 2021-08-09. PMID:34330889. |
we found that sars-cov-2 entry factors, including ace2, tmprss2, furin, and nrp1, have elevated expression in nasal squamous cells from male individuals with moderate and severe covid-19. |
2021-08-09 |
2023-08-13 |
Not clear |
| Carl A Pierce, Sharlene Sy, Benjamin Galen, Doctor Y Goldstein, Erika Orner, Marla J Keller, Kevan C Herold, Betsy C Herol. Natural mucosal barriers and COVID-19 in children. JCI insight. vol 6. issue 9. 2021-05-21. PMID:33822777. |
total protein, cytokines, and anti-sars-cov-2 igg and iga were quantified in nasal fluid.resultssars-cov-2 copies, angiotensin-converting enzyme 2, and tmprss2 gene expression were similar in children and adults, but children displayed higher expression of genes associated with ifn signaling, nlrp3 inflammasome, and other innate pathways. |
2021-05-21 |
2023-08-13 |
Not clear |
| Supinda Bunyavanich, Chantal Grant, Alfin Vicenci. Racial/Ethnic Variation in Nasal Gene Expression of Transmembrane Serine Protease 2 (TMPRSS2). JAMA. vol 324. issue 15. 2021-05-10. PMID:32910146. |
racial/ethnic variation in nasal gene expression of transmembrane serine protease 2 (tmprss2). |
2021-05-10 |
2023-08-13 |
Not clear |
| Moritz Klingenstein, Stefanie Klingenstein, Peter H Neckel, Andreas F Mack, Andreas P Wagner, Alexander Kleger, Stefan Liebau, Alfio Milazz. Evidence of SARS-CoV2 Entry Protein ACE2 in the Human Nose and Olfactory Bulb. Cells, tissues, organs. vol 209. issue 4-6. 2021-05-05. PMID:33486479. |
here, we provide a comprehensive expression landscape of ace2 and tmprss2 proteins across human postmortem nasal and olfactory tissue. |
2021-05-05 |
2023-08-13 |
human |
| Christoph Muus, Malte D Luecken, Gökcen Eraslan, Lisa Sikkema, Avinash Waghray, Graham Heimberg, Yoshihiko Kobayashi, Eeshit Dhaval Vaishnav, Ayshwarya Subramanian, Christopher Smillie, Karthik A Jagadeesh, Elizabeth Thu Duong, Evgenij Fiskin, Elena Torlai Triglia, Meshal Ansari, Peiwen Cai, Brian Lin, Justin Buchanan, Sijia Chen, Jian Shu, Adam L Haber, Hattie Chung, Daniel T Montoro, Taylor Adams, Hananeh Aliee, Samuel J Allon, Zaneta Andrusivova, Ilias Angelidis, Orr Ashenberg, Kevin Bassler, Christophe Bécavin, Inbal Benhar, Joseph Bergenstråhle, Ludvig Bergenstråhle, Liam Bolt, Emelie Braun, Linh T Bui, Steven Callori, Mark Chaffin, Evgeny Chichelnitskiy, Joshua Chiou, Thomas M Conlon, Michael S Cuoco, Anna S E Cuomo, Marie Deprez, Grant Duclos, Denise Fine, David S Fischer, Shila Ghazanfar, Astrid Gillich, Bruno Giotti, Joshua Gould, Minzhe Guo, Austin J Gutierrez, Arun C Habermann, Tyler Harvey, Peng He, Xiaomeng Hou, Lijuan Hu, Yan Hu, Alok Jaiswal, Lu Ji, Peiyong Jiang, Theodoros S Kapellos, Christin S Kuo, Ludvig Larsson, Michael A Leney-Greene, Kyungtae Lim, Monika Litviňuková, Leif S Ludwig, Soeren Lukassen, Wendy Luo, Henrike Maatz, Elo Madissoon, Lira Mamanova, Kasidet Manakongtreecheep, Sylvie Leroy, Christoph H Mayr, Ian M Mbano, Alexi M McAdams, Ahmad N Nabhan, Sarah K Nyquist, Lolita Penland, Olivier B Poirion, Sergio Poli, CanCan Qi, Rachel Queen, Daniel Reichart, Ivan Rosas, Jonas C Schupp, Conor V Shea, Xingyi Shi, Rahul Sinha, Rene V Sit, Kamil Slowikowski, Michal Slyper, Neal P Smith, Alex Sountoulidis, Maximilian Strunz, Travis B Sullivan, Dawei Sun, Carlos Talavera-López, Peng Tan, Jessica Tantivit, Kyle J Travaglini, Nathan R Tucker, Katherine A Vernon, Marc H Wadsworth, Julia Waldman, Xiuting Wang, Ke Xu, Wenjun Yan, William Zhao, Carly G K Ziegle. Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. Nature medicine. vol 27. issue 3. 2021-03-26. PMID:33654293. |
ace2, tmprss2 and ctsl are coexpressed in specific subsets of respiratory epithelial cells in the nasal passages, airways and alveoli, and in cells from other organs associated with coronavirus disease 2019 (covid-19) transmission or pathology. |
2021-03-26 |
2023-08-13 |
Not clear |
| Ming Wang, Xiangting Bu, Gaoli Fang, Ge Luan, Yanran Huang, Cezmi A Akdis, Chengshuo Wang, Luo Zhan. Distinct expression of SARS-CoV-2 receptor ACE2 correlates with endotypes of chronic rhinosinusitis with nasal polyps. Allergy. vol 76. issue 3. 2021-03-18. PMID:33210729. |
severe acute respiratory syndrome coronavirus 2 (sars-cov-2) entry factors, ace2 and tmprss2, are highly expressed in nasal epithelial cells. |
2021-03-18 |
2023-08-13 |
Not clear |
| Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Mashael Alabed, Mohamed-Hani Temsah, Saba Al Heialy, Qutayba Hamid, Rabih Halwan. Airways Expression of SARS-CoV-2 Receptor, ACE2, and TMPRSS2 Is Lower in Children Than Adults and Increases with Smoking and COPD. Molecular therapy. Methods & clinical development. vol 18. 2021-03-04. PMID:32537478. |
we have found a differential expression of ace2 and tmprss2 in nasal and bronchial airways relative to age and diseases status. |
2021-03-04 |
2023-08-13 |
human |
| Jyoti Goad, Joshua Rudolph, Aleksandar Rajkovi. Female reproductive tract has low concentration of SARS-CoV2 receptors. PloS one. vol 15. issue 12. 2021-02-12. PMID:33315943. |
recent data suggests a high concentration of sars-cov2 receptors, ace2 or tmprss2, in nasal epithelium and cornea, which explains person-to-person transmission. |
2021-02-12 |
2023-08-13 |
human |
| Yichuan Liu, Hui-Qi Qu, Jingchun Qu, Lifeng Tian, Hakon Hakonarso. Expression Pattern of the SARS-CoV-2 Entry Genes Viruses. vol 12. issue 10. 2020-11-05. PMID:33081421. |
tmprss2 is highly expressed in small airway epithelium and nasal epithelium and has lower expression in masticatory mucosa. |
2020-11-05 |
2023-08-13 |
Not clear |
| Magdalena Matusiak, Christian M Schürc. Expression of SARS-CoV-2 entry receptors in the respiratory tract of healthy individuals, smokers and asthmatics. Respiratory research. vol 21. issue 1. 2020-10-13. PMID:32993656. |
in asthmatics, ace2 tended to be downregulated in nasal epithelium, and tmprss2 was upregulated in the bronchi. |
2020-10-13 |
2023-08-13 |
human |
| Carly G K Ziegler, Samuel J Allon, Sarah K Nyquist, Ian M Mbano, Vincent N Miao, Constantine N Tzouanas, Yuming Cao, Ashraf S Yousif, Julia Bals, Blake M Hauser, Jared Feldman, Christoph Muus, Marc H Wadsworth, Samuel W Kazer, Travis K Hughes, Benjamin Doran, G James Gatter, Marko Vukovic, Faith Taliaferro, Benjamin E Mead, Zhiru Guo, Jennifer P Wang, Delphine Gras, Magali Plaisant, Meshal Ansari, Ilias Angelidis, Heiko Adler, Jennifer M S Sucre, Chase J Taylor, Brian Lin, Avinash Waghray, Vanessa Mitsialis, Daniel F Dwyer, Kathleen M Buchheit, Joshua A Boyce, Nora A Barrett, Tanya M Laidlaw, Shaina L Carroll, Lucrezia Colonna, Victor Tkachev, Christopher W Peterson, Alison Yu, Hengqi Betty Zheng, Hannah P Gideon, Caylin G Winchell, Philana Ling Lin, Colin D Bingle, Scott B Snapper, Jonathan A Kropski, Fabian J Theis, Herbert B Schiller, Laure-Emmanuelle Zaragosi, Pascal Barbry, Alasdair Leslie, Hans-Peter Kiem, JoAnne L Flynn, Sarah M Fortune, Bonnie Berger, Robert W Finberg, Leslie S Kean, Manuel Garber, Aaron G Schmidt, Daniel Lingwood, Alex K Shalek, Jose Ordovas-Montane. SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. Cell. vol 181. issue 5. 2020-06-05. PMID:32413319. |
we identify ace2 and tmprss2 co-expressing cells within lung type ii pneumocytes, ileal absorptive enterocytes, and nasal goblet secretory cells. |
2020-06-05 |
2023-08-13 |
mouse |