| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yao Wang, Yan-Chun Wang, Jun M. Effects of electroacupuncture on Sirt3/NLRP3/GSDMD signaling pathway in the substantia nigra of midbrain of rats with Parkinson's disease. Zhen ci yan jiu = Acupuncture research. vol 49. issue 4. 2024-04-22. PMID:38649206. |
to observe the effects on tyrosine hydroxylase (th), α-synaptic nucleoprotein (α-syn), sirtuin 3 (sirt3), nod-like receptor 3 (nlrp3) and gasdermin-d (gsdmd) in the substantia nigra of midbrain after electroacupuncture (ea) at "fengfu"(gv16), "taichong" (lr3) and "zusanli" (st36) in rats of parkinson's disease (pd), so as to explore the mechanism of ea in treatment of pd. |
2024-04-22 |
2024-04-26 |
rat |
| Cian-Fen Jhuo, Chun-Jung Chen, Jason T C Tzen, Wen-Ying Che. Teaghrelin protected dopaminergic neurons in MPTP-induced Parkinson's disease animal model by promoting PINK1/Parkin-mediated mitophagy and AMPK/SIRT1/PGC1-α-mediated mitochondrial biogenesis. Environmental toxicology. 2024-04-16. PMID:38622810. |
tyrosine hydroxylase and dopamine transporter protein were found reduced in the striatum and midbrain of mptp-treated mice, and significantly mitigated by teaghrelin supplementation. |
2024-04-16 |
2024-04-18 |
mouse |
| Cian-Fen Jhuo, Chun-Jung Chen, Jason T C Tzen, Wen-Ying Che. Teaghrelin protected dopaminergic neurons in MPTP-induced Parkinson's disease animal model by promoting PINK1/Parkin-mediated mitophagy and AMPK/SIRT1/PGC1-α-mediated mitochondrial biogenesis. Environmental toxicology. 2024-04-16. PMID:38622810. |
tyrosine hydroxylase and dopamine transporter protein were found reduced in the striatum and midbrain of mptp-treated mice, and significantly mitigated by teaghrelin supplementation. |
2024-04-16 |
2024-04-18 |
mouse |
| Chiara Prodani, Elaine E Irvine, Alessandro Sardini, Hannah J Gleneadie, Andrew Dimond, Mathew Van de Pette, Rosalind John, Michelle Kokkinou, Oliver Howes, Dominic J Withers, Mark A Ungless, Matthias Merkenschlager, Amanda G Fishe. Protein restriction during pregnancy alters Cdkn1c silencing, dopamine circuitry and offspring behaviour without changing expression of key neuronal marker genes. Scientific reports. vol 14. issue 1. 2024-04-12. PMID:38609446. |
exposure to lpd in utero resulted in significantly more tyrosine hydroxylase positive (dopaminergic) neurons in the midbrain of adult offspring as compared to age-matched, control-diet equivalents. |
2024-04-12 |
2024-04-15 |
mouse |
| Nicole Burkert, Shoumik Roy, Max Häusler, Dominik Wuttke, Sonja Müller, Johanna Wiemer, Helene Hollmann, Marvin Oldrati, Jorge Ramirez-Franco, Julia Benkert, Michael Fauler, Johanna Duda, Jean-Marc Goaillard, Christina Pötschke, Moritz Münchmeyer, Rosanna Parlato, Birgit Lis. Deep learning-based image analysis identifies a DAT-negative subpopulation of dopaminergic neurons in the lateral Substantia nigra. Communications biology. vol 6. issue 1. 2023-11-10. PMID:37950046. |
we utilised dlap to analyse subtypes of tyrosine hydroxylase (th)-positive dopaminergic midbrain neurons in mouse and human brain-sections. |
2023-11-10 |
2023-11-20 |
mouse |
| Yalan Chen, Junxin Kuang, Yimei Niu, Hongyao Zhu, Xiaoxia Chen, Kwok-Fai So, Anding Xu, Lingling Sh. Multiple factors to assist human-derived induced pluripotent stem cells to efficiently differentiate into midbrain dopaminergic neurons. Neural regeneration research. vol 19. issue 4. 2023-10-16. PMID:37843228. |
we further optimized the induction protocol by applying the small molecule inhibitor, chir99021 (chir).this helped facilitate the generation of midbrain dopaminergic neurons, and we obtained 31-74% midbrain dopaminergic neurons based on tyrosine hydroxylase and foxa2 staining. |
2023-10-16 |
2023-11-08 |
human |
| Yalan Chen, Junxin Kuang, Yimei Niu, Hongyao Zhu, Xiaoxia Chen, Kwok-Fai So, Anding Xu, Lingling Sh. Multiple factors to assist human-derived induced pluripotent stem cells to efficiently differentiate into midbrain dopaminergic neurons. Neural regeneration research. vol 19. issue 4. 2023-10-16. PMID:37843228. |
based on tyrosine hydroxylase and foxa2 immunostaining analysis, the chir, shh, and fgf8 combined protocol produces a much higher proportion of midbrain dopaminergic neurons, which could be an ideal resource for tackling midbrain-related diseases. |
2023-10-16 |
2023-11-08 |
human |
| Sibylle Frase, Julius Steddin, Enya Paschen, Maximilian Lenz, Pasquale Conforti, Carola A Haas, Andreas Vlachos, Christian Schachtrup, Jonas A Hos. Dense dopaminergic innervation of the peri-infarct cortex despite dopaminergic cell loss after a pure motor-cortical stroke in rats. Journal of neurochemistry. 2023-09-22. PMID:37735852. |
thus, dopaminergic midbrain neurons projecting into the pic were identified based on mr signal and immunoreactivity against tyrosine hydroxylase (th), a marker for dopaminergic neurons. |
2023-09-22 |
2023-10-07 |
rat |
| Charlotte Helf, Maria Kober, Franz Markert, Jennifer Lanto, Leonie Overhoff, Kathrin Badstübner-Meeske, Alexander Storch, Mareike Fause. Subthalamic nucleus deep brain stimulation induces nigrostriatal dopaminergic plasticity in a stable rat model of Parkinson's disease. Neuroreport. vol 34. issue 10. 2023-06-04. PMID:37270842. |
in the context of identifying disease-modifying effects of stn-dbs by prompting cellular plasticity in midbrain dopaminergic systems, we analyzed neuronal tyrosine hydroxylase and c-fos expression in the substantia nigra pars compacta (snpc) and ventral tegmental area (vta). |
2023-06-04 |
2023-08-14 |
rat |
| Vagdevi Hangarakatte Ramachandra, Senthilkumar Sivanesan, Anand Koppal, Shanmugam Anandakumar, Matthew D Howell, Ethirajan Sukumar, Rajagopalan Vijayaraghava. Embelin and levodopa combination therapy for improved Parkinson's disease treatment. Translational neuroscience. vol 13. issue 1. 2022-07-20. PMID:35855085. |
in the substantia nigra (midbrain), tyrosine hydroxylase (th) expression was examined by immunohistochemistry, and nurr1 expression was evaluated by western blotting. |
2022-07-20 |
2023-08-14 |
mouse |
| b' Joseane Morari, Roberta Haddad-T\\xc3\\xb3volli, Pedro Augusto Silva Nogueira, Caio Jord\\xc3\\xa3o Teixeira, Rafael Mar\\xc3\\xb3stica, Nat\\xc3\\xa1lia Tobar, Celso Dario Ramos, Licio Augusto Velloso, Vanessa Cristina Dias Bobbo, Gabriel Forato Anh\\xc3\\xa. Body mass variability in age-matched outbred male Swiss mice is associated to differential control of food intake by ghrelin. Molecular and cellular endocrinology. 2022-04-12. PMID:35413387.' |
on the other hand, the response to jmv3002 seen in pbmg was hallmarked by singular transcriptional response in the midbrain characterized by a simultaneous increase in both tyrosine hydroxylase (th) and proopiomelanocortin (pomc) expressions. |
2022-04-12 |
2023-08-13 |
mouse |
| Xin Liu, Zhong Rui Du, Xiong Wang, Xiang Rong Sun, Qing Zhao, Fang Zhao, Wing Tak Wong, Ka Hing Wong, Xiao-Li Don. Polymannuronic acid prebiotic plus Lacticaseibacillus rhamnosus GG probiotic as a novel synbiotic promoted their separate neuroprotection against Parkinson's disease. Food research international (Ottawa, Ont.). vol 155. 2022-04-11. PMID:35400445. |
our results found oral administration of prebiotic pm or lgg separately or in combination for 5 weeks could prevent dopaminergic neuronal loss via improving reduced walking distance and activity or weakened muscle strength in behavior tests by enhancing tyrosine hydroxylase (th) gene and/or protein expressions in the midbrain and striatum of pd mice. |
2022-04-11 |
2023-08-13 |
mouse |
| Aleksandar Rakovic, Dorothea Voß, Franca Vulinovic, Britta Meier, Ann-Katrin Hellberg, Carla Nau, Christine Klein, Enrico Leipol. Electrophysiological Properties of Induced Pluripotent Stem Cell-Derived Midbrain Dopaminergic Neurons Correlate With Expression of Tyrosine Hydroxylase. Frontiers in cellular neuroscience. vol 16. 2022-04-11. PMID:35401116. |
electrophysiological properties of induced pluripotent stem cell-derived midbrain dopaminergic neurons correlate with expression of tyrosine hydroxylase. |
2022-04-11 |
2023-08-13 |
Not clear |
| Qi Hu, Mei Hong, Mengyang Huang, Quan Gong, Xiaofan Zhang, Vladimir N Uversky, Francisco Pan-Montojo, Teng Huang, Honglian Zhou, Suiqiang Zh. Age-dependent aggregation of α-synuclein in the nervous system of gut-brain axis is associated with caspase-1 activation. Metabolic brain disease. 2022-01-28. PMID:35089485. |
whereas, the expression of tyrosine hydroxylase (th), the rate-limiting enzyme for dopamine synthesis, was decreased with aging in the midbrain. |
2022-01-28 |
2023-08-13 |
mouse |
| Abdelaati El Khiat, Omar El Hiba, Lahcen Tamegart, Hanane Rais, Naima Fdil, Souad Sellami, Mohamed Ait El Mokhtar, Halima Gamran. Time dependent alteration of locomotor behavior in rat with acute liver failure induced cerebellar neuroinflammation and neuro-astroglial damage. Journal of chemical neuroanatomy. vol 119. 2021-12-11. PMID:34863855. |
hepatic and renal functions were assessed via various biochemical and histopathological examinations, while the cerebellum and the midbrain were examined using histology and immunohistochemistry for tyrosine hydroxylase (th), cyclooxygenase-2 (cox-2) and glial fibrillary acidic protein (gfap). |
2021-12-11 |
2023-08-13 |
rat |
| Ling Qi, Yao Wang, Ya-Nan Li, Lei Guo, Jun M. [Electroacupuncture improves behavioral activities by suppressing neuroinflammation and TLR4/NF-κB signaling in substantia nigra of midbrain in Parkinson's disease rats]. Zhen ci yan jiu = Acupuncture research. vol 46. issue 11. 2021-12-08. PMID:34865329. |
to observe the effect of electroacupuncture(ea) at "fengfu" (gv16) and "taichong"(lr3) on the expression of tyrosine hydroxylase (th), α-synuclein (α-syn) and microglial-related microglial (mg), toll-like receptor 4（tlr4）/nuclear factor kappa b （nf-κb） signaling pathway in the substantia nigra (sn) of midbrain in rotenone-induced parkinson's disease (pd) rats, so as to explore its mechanisms underlying improvement of pd. |
2021-12-08 |
2023-08-13 |
rat |
| V Mesa-Infante, D Afonso-Oramas, J Salas-Hernández, J Rodríguez-Núñez, P Barroso-Chine. Long-term exposure to GDNF induces dephosphorylation of Ret, AKT, and ERK1/2, and is ineffective at protecting midbrain dopaminergic neurons in cellular models of Parkinson's disease. Molecular and cellular neurosciences. vol 118. 2021-12-07. PMID:34826608. |
the results showed that short-term or acute (15 min, 24 h, and 24 h (7 days)) gdnf treatment in rat midbrain neurons increases tyrosine hydroxylase (th) expression and the phosphorylation levels of ret (tyr 1062), akt (ser 473), erk1/2 (thr202/tyr204), s6 (ser 235/236), and gsk3-β (ser 9). |
2021-12-07 |
2023-08-13 |
rat |
| D Halperin, A Stavsky, R Kadir, M Drabkin, O Wormser, Y Yogev, V Dolgin, R Proskorovski-Ohayon, Y Perez, H Nudelman, O Stoler, B Rotblat, T Lifschytz, A Lotan, G Meiri, D Gitler, O S Bir. CDH2 mutation affecting N-cadherin function causes attention-deficit hyperactivity disorder in humans and mice. Nature communications. vol 12. issue 1. 2021-11-30. PMID:34702855. |
specific downstream molecular pathways were affected in both the ventral midbrain and prefrontal cortex, with reduced tyrosine hydroxylase expression and dopamine levels. |
2021-11-30 |
2023-08-13 |
mouse |
| Anna Maria Lavezz. Altered Development of Mesencephalic Dopaminergic Neurons in SIDS: New Insights into Understanding Sudden Infant Death Pathogenesis. Biomedicines. vol 9. issue 11. 2021-11-30. PMID:34829763. |
dopaminergic structures in midbrain sections of a large series of sudden infant deaths (36 sids and 26 controls) were identified using polyclonal rabbit antibodies against tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis, and the dopamine transporter, a membrane protein specifically expressed in dopaminergic cells. |
2021-11-30 |
2023-08-13 |
human |
| Xuezhu Cai, Ian C Harding, Aymen H Sadaka, Bradley Colarusso, Praveen Kulkarni, Eno Ebong, Ju Qiao, Nick R O'Hare, Craig F Ferri. Mild repetitive head impacts alter perivascular flow in the midbrain dopaminergic system in awake rats. Brain communications. vol 3. issue 4. 2021-11-23. PMID:34806002. |
the histology showed a significant level of neuroinflammation in the midbrain dopaminergic system 3 weeks post mild repetitive head impact but no loss in tyrosine hydroxylase. |
2021-11-23 |
2023-08-13 |
rat |