| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cian-Fen Jhuo, Chun-Jung Chen, Jason T C Tzen, Wen-Ying Che. Teaghrelin protected dopaminergic neurons in MPTP-induced Parkinson's disease animal model by promoting PINK1/Parkin-mediated mitophagy and AMPK/SIRT1/PGC1-α-mediated mitochondrial biogenesis. Environmental toxicology. 2024-04-16. PMID:38622810. |
tyrosine hydroxylase and dopamine transporter protein were found reduced in the striatum and midbrain of mptp-treated mice, and significantly mitigated by teaghrelin supplementation. |
2024-04-16 |
2024-04-18 |
mouse |
| Cian-Fen Jhuo, Chun-Jung Chen, Jason T C Tzen, Wen-Ying Che. Teaghrelin protected dopaminergic neurons in MPTP-induced Parkinson's disease animal model by promoting PINK1/Parkin-mediated mitophagy and AMPK/SIRT1/PGC1-α-mediated mitochondrial biogenesis. Environmental toxicology. 2024-04-16. PMID:38622810. |
tyrosine hydroxylase and dopamine transporter protein were found reduced in the striatum and midbrain of mptp-treated mice, and significantly mitigated by teaghrelin supplementation. |
2024-04-16 |
2024-04-18 |
mouse |
| Chunying Guo, Ting Wang, Haiyan Huang, Xiaolu Wang, Yugui Jiang, Jinan L. Plasminogen degrades α-synuclein, Tau and TDP-43 and decreases dopaminergic neurodegeneration in mouse models of Parkinson's disease. Scientific reports. vol 14. issue 1. 2024-04-13. PMID:38615036. |
the in vitro, ex vivo and in vivo results showed that the administered plasminogen crossed the blood‒brain barrier (bbb), entered cells, and migrated to the nucleus, increased plasmin activity intracellularly, bound to α-syn through lysine binding sites, significantly promoted α-syn, tau and tdp-43 clearance intracellularly and even intranuclearly in the brain, decreased dopaminergic neurodegeneration and increased the tyrosine hydroxylase levels in the substantia nigra and striatum, and improved motor function in pd mouse models. |
2024-04-13 |
2024-04-16 |
mouse |
| Amina Essawy Essawy, Oryhan Aly Abou-ElNaga, Radwa Ali Mehanna, Noha Mohammed Badae, Eman Sheta Elsawy, Ahmed Abdelmagied Soffa. Comparing the effect of intravenous versus intracranial grafting of mesenchymal stem cells against parkinsonism in a rat model: Behavioral, biochemical, pathological and immunohistochemical studies. PloS one. vol 19. issue 2. 2024-02-13. PMID:38349932. |
substantia nigra and striatum tissues were examined histologically and the molecular expression of dopa decarboxylase, tyrosine hydroxylase, and α-synuclein in neurons in these tissues were investigated. |
2024-02-13 |
2024-02-16 |
rat |
| Raman Kumar Tripathi, Lav Goyal, Shamsher Sing. Potential Therapeutic Approach Using Aromatic l-amino Acid Decarboxylase and Glial-derived Neurotrophic Factor Therapy Targeting Putamen in Parkinson's Disease. Current gene therapy. 2024-02-04. PMID:38310455. |
enhancing the enzymatic activity of tyrosine hydroxylase (th), glucocorticoid hormone (gch), and aadc in the striatum would be useful for external l-dopa to restore the dopamine (da) level. |
2024-02-04 |
2024-02-06 |
Not clear |
| Xi Chen, Zhao Wang, Weihua Yang, Yuejun F. Levodopa Improves Behavioral Deficits of Mice with Parkinson's Disease Symptoms via Curbing NLRP3 Inflammasome Activation and Enhancing Tyrosine Hydroxylase Levels in the Striatum and Substantia Nigra. Journal of integrative neuroscience. vol 23. issue 1. 2024-01-30. PMID:38287845. |
levodopa improves behavioral deficits of mice with parkinson's disease symptoms via curbing nlrp3 inflammasome activation and enhancing tyrosine hydroxylase levels in the striatum and substantia nigra. |
2024-01-30 |
2024-02-01 |
mouse |
| Xi Chen, Zhao Wang, Weihua Yang, Yuejun F. Levodopa Improves Behavioral Deficits of Mice with Parkinson's Disease Symptoms via Curbing NLRP3 Inflammasome Activation and Enhancing Tyrosine Hydroxylase Levels in the Striatum and Substantia Nigra. Journal of integrative neuroscience. vol 23. issue 1. 2024-01-30. PMID:38287845. |
this study aims to probe the action of l-dopa on nlr pyrin domain containing 3 (nlrp3) inflammasome activation and tyrosine hydroxylase (th) levels in the striatum (str) and substantia nigra (sn) of mice with pd symptoms. |
2024-01-30 |
2024-02-01 |
mouse |
| Kelli Somelar-Duracz, Monika Jürgenson, Janeli Viil, Alexander Zharkovsky, Külli Jaak. 'Unpredictable chronic mild stress does not exacerbate memory impairment or altered neuronal and glial plasticity in the hippocampus of middle-aged vitamin D deficient mice'. The European journal of neuroscience. 2024-01-25. PMID:38269959. |
moreover, tyrosine hydroxylase levels decreased in the striatum of vdd mice, but not in stressed vdd mice. |
2024-01-25 |
2024-01-27 |
mouse |
| Adedamola Bayo-Olugbami, AbdulRazaq Bidemi Nafiu, Abdulbasit Amin, Olalekan Michael Ogundele, Charles C Lee, Bamidele Victor Owoyel. Cholecalciferol (VD3) Attenuates L-DOPA-Induced Dyskinesia in Parkinsonian Mice Via Modulation of Microglia and Oxido-Inflammatory Mechanisms. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. vol 37. issue 2. 2024-01-20. PMID:38243560. |
using western blot, striatum was assessed for expression of dopamine metabolic enzymes: tyrosine hydroxylase (th) and monoamine oxidase-b (mao-b); cd11b, bax, p47phox, and il-1β. |
2024-01-20 |
2024-01-22 |
mouse |
| Jun Sung Park, Riaz Ahmad, Kyonghwan Choe, Min Hwa Kang, Tae Ju Park, Myeong Ok Ki. Immunization Effects of a Novel α-Synuclein-Based Peptide Epitope Vaccine in Parkinson's Disease-Associated Pathology. Vaccines. vol 11. issue 12. 2023-12-23. PMID:38140224. |
furthermore, vaccinated groups, especially ova and klh groups, showed decrease in α-syn levels and increased dopamine-related markers, i.e., tyrosine hydroxylase (th), vesicle monoamine transporter 2 (vmat2), and dopamine transporter (dat), and autophagy activities in the striatum and snpc. |
2023-12-23 |
2023-12-25 |
mouse |
| Rachael A Herlihy, Francisco Alicandri, Hudy Berger, Huda Rehman, Yifan Kao, Kainat Akhtar, Elizabeth Dybas, Emily Mahoney-Rafferty, Kassie Von Stein, Raven Kirby, Angela Tawfik, Rachel Skumurski, Paul J Feustel, Eric S Molho, Damian S Shi. Investigation of non-invasive focused ultrasound efficacy on depressive-like behavior in hemiparkinsonian rats. Experimental brain research. 2023-12-07. PMID:38059986. |
after, tyrosine hydroxylase immuno-staining was employed to visualize and quantify dopaminergic degeneration in the substantia nigra pars compacta, ventral tegmental area, and striatum. |
2023-12-07 |
2023-12-10 |
rat |
| Jong Mi Park, Masoud Rahmati, Sang Chul Lee, Jae Il Shin, Yong Wook Ki. Effects of mesenchymal stem cell on dopaminergic neurons, motor and memory functions in animal models of Parkinson's disease: a systematic review and meta-analysis. Neural regeneration research. vol 19. issue 7. 2023-12-05. PMID:38051903. |
the stem cell treatment group had significantly more tyrosine hydroxylase positive dopaminergic neurons in the striatum ([95% ci] = 1.04 [0.59 to 1.49], p = 0.0001, i2 = 65.1 %) and substantia nigra (smd [95% ci] = 1.38 [0.89 to 1.87], p = 0.0001, i2 = 75.3 %), indicating a protective effect on dopaminergic neurons. |
2023-12-05 |
2023-12-10 |
Not clear |
| Li-Min Mao, Khyathi Thallapureddy, John Q Wan. Effects of propofol on presynaptic synapsin phosphorylation in the mouse brain in vivo. Brain research. 2023-11-12. PMID:37952872. |
propofol also elevated synapsin phosphorylation at these sites in the striatum and s9 and s62/67 phosphorylation in the hippocampus, while propofol had no effect on tyrosine hydroxylase phosphorylation in striatal nerve terminals. |
2023-11-12 |
2023-11-20 |
mouse |
| Daiane Cattani, Paula Pierozan, Ariane Zamoner, Eva Brittebo, Oskar Karlsso. Long-Term Effects of Perinatal Exposure to a Glyphosate-Based Herbicide on Melatonin Levels and Oxidative Brain Damage in Adult Male Rats. Antioxidants (Basel, Switzerland). vol 12. issue 10. 2023-10-30. PMID:37891904. |
moreover, perinatal gbh exposure significantly increased the total number of neurons (20%) and tyrosine hydroxylase (th)-positive neurons (38%) in the adult striatum. |
2023-10-30 |
2023-11-08 |
rat |
| Sally Hamdon, Pol Fernandez-Gonzalez, Muhammad Yusof Omar, Marta González-Sepúlveda, Jordi Ortiz, Carles Gi. CHIR99021 causes inactivation of Tyrosine Hydroxylase and depletion of dopamine in rat brain striatum. Neuropharmacology. 2023-10-16. PMID:37844866. |
chir99021 causes inactivation of tyrosine hydroxylase and depletion of dopamine in rat brain striatum. |
2023-10-16 |
2023-11-08 |
rat |
| Sai Teja Meka, Sree Lalitha Bojja, Gautam Kumar, Sumit Raosaheb Birangal, C Mallikarjuna Ra. Novel HDAC inhibitors provide neuroprotection in MPTP-induced Parkinson's disease model of rats. European journal of pharmacology. 2023-09-26. PMID:37751833. |
mptp administration resulted in a marked rise in lipid peroxidation, and interleukin-1β concentration accompanied by reduced tyrosine hydroxylase and dopamine levels in the striatum compared to the sham group. |
2023-09-26 |
2023-10-07 |
rat |
| Tali Fishman-Jacob, Moussa B H Youdi. A sporadic Parkinson's disease model via silencing of the ubiquitin-proteasome/E3 ligase component, SKP1A. Journal of neural transmission (Vienna, Austria : 1996). 2023-08-29. PMID:37644186. |
the injected lv skp1shrna to mouse sn resulted in decreased expression of skp1 protein levels within daergic neurons and loss of tyrosine hydroxylase immunoreactivity (th-ir) in both snpc and striatum that was accompanied by time-dependent motor disabilities. |
2023-08-29 |
2023-09-07 |
mouse |
| Ella A Kasanga, Yoonhee Han, Marla K Shifflet, Walter Navarrete, Robert McManus, Caleb Parry, Arturo Barahona, Vicki A Nejtek, Fredric P Manfredsson, Jeffrey H Kordower, Jason R Richardson, Michael F Salvator. Nigral-specific increase in ser31 phosphorylation compensates for tyrosine hydroxylase protein and nigrostriatal neuron loss: Implications for delaying parkinsonian signs. Experimental neurology. 2023-08-27. PMID:37634696. |
compensatory mechanisms that augment dopamine (da) signaling are thought to mitigate onset of hypokinesia prior to major loss of tyrosine hydroxylase (th) in striatum that occurs in parkinson's disease. |
2023-08-27 |
2023-09-07 |
rat |
| Luis Fernando Narváez-Pérez, Francisco Paz-Bermúdez, José Arturo Avalos-Fuentes, Aurelio Campos-Romo, Benjamín Florán-Garduño, José Segovi. CRISPR/sgRNA-directed synergistic activation mediator (SAM) as a therapeutic tool for Parkinson´s disease. Gene therapy. 2023-08-04. PMID:37542151. |
as a proof-of-concept for the treatment of pd, we used sam, a crispr gene activation system, to activate the endogenous tyrosine hydroxylase gene (th) of astrocytes to produce dopamine (da) in the striatum of 6-ohda-lesioned rats. |
2023-08-04 |
2023-08-14 |
rat |
| Zhili Ren, Hong Sun, Shuangling Xiu, Nan Yang, Yanyong Liu, Piu Cha. Investigation of rhodamine derivative on behavioral impairment in a double neurotoxin lesion of substantia nigra and locus coeruleus dysfunctional mice. European journal of pharmacology. 2023-08-03. PMID:37536627. |
it rescued the levels of tyrosine hydroxylase in substantia nigra, and striatum. |
2023-08-03 |
2023-08-14 |
mouse |