| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Tuba Kaya, G J Gert-Jan Braunstahl, J C C M Johannes In 't Veen, J H Jasper Kappen, J P M Hanna van der Val. The Fractional exhaled Nitric Oxide (FeNO)- test as add-on test in the diagnostic work-up of asthma: a study protocol. BMC pulmonary medicine. vol 24. issue 1. 2024-04-15. PMID:38622520. |
the global initiative of asthma guideline recommends a flowchart to diagnose asthma with first-step spirometry with reversibility and a bronchial challenge test (bpt) with histamine or methacholine as a second step [1]. |
2024-04-15 |
2024-04-18 |
Not clear |
| Peter Bradding, Celeste Porsbjerg, Andréanne Côté, Sven-Erik Dahlén, Teal S Hallstrand, Christopher E Brightlin. Airway hyperresponsiveness in asthma: the role of the epithelium. The Journal of allergy and clinical immunology. 2024-02-23. PMID:38395082. |
dysfunctional airway smooth muscle (asm) significantly contributes to ahr and is displayed as increased sensitivity to direct pharmacological bronchoconstrictor stimuli, such as inhaled histamine and methacholine (direct ahr), or to endogenous mediators released by activated airway cells such as mast cells (indirect ahr). |
2024-02-23 |
2024-02-26 |
human |
| Ajay P Nayak, Elham Javed, Dominic R Villalba, Yinna Wang, Henry P Morelli, Sushrut D Shah, Nicholas Kim, Rennolds S Ostrom, Reynold A Panettieri, Steven S An, Dale D Tang, Raymond B Pen. Prorelaxant E-type Prostanoid Receptors Functionally Partition to Different Procontractile Receptors in Airway Smooth Muscle. American journal of respiratory cell and molecular biology. vol 69. issue 5. 2023-11-01. PMID:37523713. |
we used ep2 and ep4 subtype-specific agonists (ono-259 and ono-329, respectively) in cell- and tissue-based models of human asm contraction-magnetic twisting cytometry (mtc), and precision-cut lung slices (pclss), respectively-to study the ep2 and ep4 regulation of asm contraction and signaling under conditions of histamine or methacholine (mch) stimulation. |
2023-11-01 |
2023-11-08 |
human |
| Ajay P Nayak, John M Lim, Eylon Arbel, Ruping Wang, Dominic R Villalba, Tahn L Nguyen, Niccole Schaible, Ramaswamy Krishnan, Dale D Tang, Raymond B Pen. Cooperativity between β-agonists and c-Abl inhibitors in regulating airway smooth muscle relaxation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 7. 2021-07-19. PMID:34115899. |
the cooperative effect of β-agonists (isoproterenol) and c-abl inhibitors (gnf-5, or imatinib) on contractile agonist (methacholine, or histamine) -induced asm contraction was assessed in cultured human asm cells (using fourier transfer traction microscopy), in murine precision cut lung slices, and in vivo (flexivent in mice). |
2021-07-19 |
2023-08-13 |
mouse |
| b' Paul G Lassmann-Klee, Britt-Marie Sundblad, Leo P Malmberg, Anssi R A Sovij\\xc3\\xa4rvi, P\\xc3\\xa4ivi Piiril\\xc3\\xa. Measurement of bronchial hyperreactivity: comparison of three Nordic dosimetric methods. Scandinavian journal of clinical and laboratory investigation. vol 80. issue 3. 2021-07-16. PMID:32031428.' |
we recruited 31 patients with suspected asthma and health care workers and performed bhr testing with methacholine according to malmberg and nieminen methods, and with histamine according to sovijärvi. |
2021-07-16 |
2023-08-13 |
Not clear |
| Myoung Kyu Lee, Hyoung Kyu Yoon, Sei Won Kim, Tae Hyung Kim, Seoung Ju Park, Young Min Le. Nonspecific Bronchoprovocation Test. Tuberculosis and respiratory diseases. vol 80. issue 4. 2020-10-01. PMID:28905530. |
direct bronchoprovocation testing using methacholine or histamine may have superior sensitivity as these substances directly stimulate the airway smooth muscle cells. |
2020-10-01 |
2023-08-13 |
Not clear |
| Brenda J Marsh, Allison D Fryer, David B Jacoby, Matthew G Drak. Transient receptor potential ankyrin-1 causes rapid bronchodilation via nonepithelial PGE American journal of physiology. Lung cellular and molecular physiology. vol 318. issue 5. 2020-07-24. PMID:32233794. |
tissues were contracted with methacholine, histamine, or potassium chloride and then treated with aitc or cinn. |
2020-07-24 |
2023-08-13 |
mouse |
| Gijs Ijpma, Chu Qiao Liang, Linda Kachmar, Alice Panariti, Andrea Benedetti, Jean-Pierre Lavoie, Anne-Marie Lauzo. Maintenance of contractile function of isolated airway smooth muscle after cryopreservation. American journal of physiology. Lung cellular and molecular physiology. vol 315. issue 5. 2019-09-06. PMID:30091377. |
we measured methacholine (mch), histamine, and isoproterenol (iso) dose-responses and electrical field stimulation (efs) and mch force-velocity curves. |
2019-09-06 |
2023-08-13 |
human |
| Gergely H Fodor, Adam L Balogh, Roberta Sudy, Orsolya Ivankovits-Kiss, Barna Babik, Ferenc Peta. Dopamine ameliorates bronchoconstriction induced by histaminergic and cholinergic pathways in rabbits. Respiratory physiology & neurobiology. vol 259. 2019-04-03. PMID:30367990. |
airway resistance, tissue damping and tissue elastance were measured in anesthetized mechanically ventilated rabbits under baseline conditions, during steady-state bronchoconstriction induced by methacholine or histamine, and following intravenous dopamine (5 and 15 μg/kg/min). |
2019-04-03 |
2023-08-13 |
Not clear |
| Gergely H Fodor, Adam L Balogh, Roberta Sudy, Orsolya Ivankovits-Kiss, Barna Babik, Ferenc Peta. Dopamine ameliorates bronchoconstriction induced by histaminergic and cholinergic pathways in rabbits. Respiratory physiology & neurobiology. vol 259. 2019-04-03. PMID:30367990. |
bronchoconstriction induced by methacholine and histamine was significantly ameliorated by dopamine (14.8 ± 2.9% and 14.9 ± 2.9%; p < 0.05 for both), with no difference between the mode of stimuli. |
2019-04-03 |
2023-08-13 |
Not clear |
| Lennart K A Lundblad, Nazey Gülec, Matthew E Poynter, Victoria L DeVault, Oliver Dienz, Jonathan E Boyson, Nirav Daphtary, Minara Aliyeva, Jennifer L Ather, Felix Scheuplein, Robert Schau. The role of iNKT cells on the phenotypes of allergic airways in a mouse model. Pulmonary pharmacology & therapeutics. vol 45. 2018-04-19. PMID:28483562. |
inkt cells and mast cells have both been implicated in the syndrome of allergic asthma through their activation-induced release of th2 type cytokines and secretion of histamine and other mediators, respectively, which can promote airways hyperresponsiveness (ahr) to agents such as methacholine. |
2018-04-19 |
2023-08-13 |
mouse |
| Tjitske A Oenema, Harm Maarsingh, Marieke Smit, Geny M M Groothuis, Herman Meurs, Reinoud Gosen. Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices. PloS one. vol 8. issue 6. 2017-10-10. PMID:23840342. |
mechanistic studies demonstrated that methacholine-induced bronchoconstriction mediated the release of biologically active tgf-β, which caused the increased contractile protein expression, as inhibition of actin polymerization (latrunculin a) or tgf-β receptor kinase (sb431542) prevented the methacholine effects, whereas other bronchoconstricting agents (histamine and kcl) mimicked the effects of methacholine. |
2017-10-10 |
2023-08-12 |
Not clear |
| Shao-Cheng Liu, Chun-Shu Lin, Shyi-Gen Chen, Yueng-Hsiang Chu, Fei-Peng Lee, Hsuan-Hsuan Lu, Hsing-Won Wan. Effect of budesonide and azelastine on histamine signaling regulation in human nasal epithelial cells. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. vol 274. issue 2. 2017-03-02. PMID:27623823. |
then, we used histamine and methacholine to stimulate the mucus secretion from hnepc and observed the muc5ac expression in culture supernatants. |
2017-03-02 |
2023-08-13 |
human |
| Shao-Cheng Liu, Chun-Shu Lin, Shyi-Gen Chen, Yueng-Hsiang Chu, Fei-Peng Lee, Hsuan-Hsuan Lu, Hsing-Won Wan. Effect of budesonide and azelastine on histamine signaling regulation in human nasal epithelial cells. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. vol 274. issue 2. 2017-03-02. PMID:27623823. |
histamine and methacholine stimulated muc5ac secretion was greater in cells treated with budesonide but was lesser in those treated with azelastine, as compared to controls. |
2017-03-02 |
2023-08-13 |
human |
| E Kovacova-Hanuskova, S Gavliakova, T Buday, P Kosutova, D Mokra, A Urbanova-Fulmekova, J Mokry, J Plevkov. The effect of selective antagonist of H4 receptor JNJ7777120 on nasal symptoms, cough, airway reactivity and inflammation in guinea pigs. Respiratory physiology & neurobiology. vol 216. 2016-05-04. PMID:26003849. |
this compound significantly inhibited airway reactivity to histamine, but not methacholine. |
2016-05-04 |
2023-08-13 |
Not clear |
| Saeideh Saadat, Mostafa Mohammadi, Maryam Fallahi, Rana Keyhanmanesh, Mohammad Reza Aslan. The protective effect of α-hederin, the active constituent of Nigella sativa, on tracheal responsiveness and lung inflammation in ovalbumin-sensitized guinea pigs. The journal of physiological sciences : JPS. vol 65. issue 3. 2016-04-22. PMID:25752254. |
the responsiveness of tracheal smooth muscle (tr) to methacholine, histamine and ovalbumin was assessed. |
2016-04-22 |
2023-08-13 |
Not clear |
| M Lluch-Bernal, M T Dordal, E Antón, P Campo, C Colás, I Dávila, A Del Cuvillo Bernal, B Fernández-Parra, R González, M L González, V Matheu, J Montoro, C Panizo, C Rondón, M C Sánchez, A Valero, F Vega, E Velázquez, A Navarr. Nasal Hyperreactivity: Nonspecific Nasal Provocation Tests. Review by the Rhinoconjunctivitis Committee of the Spanish Society of Allergy and Clinical Immunology. Journal of investigational allergology & clinical immunology. vol 25. issue 6. 2016-02-11. PMID:26817136. |
various stimuli (methacholine, histamine, adenosine 5'-monophosphate, cold air, mannitol, rapsaicin, phentolamine, and distilled water) have been used in an attempt to find the test that most reliably differentiates between healthy individuals and patients and also between different types of rhinitis. |
2016-02-11 |
2023-08-13 |
human |
| Laura Lucarini, Alessandro Pini, Elisabetta Gerace, Roberto Pellicciari, Emanuela Masini, Flavio Moron. Poly(ADP-ribose) polymerase inhibition with HYDAMTIQ reduces allergen-induced asthma-like reaction, bronchial hyper-reactivity and airway remodelling. Journal of cellular and molecular medicine. vol 18. issue 3. 2015-04-02. PMID:24444146. |
asthma-like signs, bronchial hyper-reactivity to methacholine, cytokine production, histamine release from mast cells, airway remodelling, collagen deposition and lung damage were evaluated. |
2015-04-02 |
2023-08-12 |
Not clear |
| Evelyne Israël Assayag, Marie-Josée Beaulieu, Yvon Cormie. Bronchodilatory and anti-inflammatory effects of ASM-024, a nicotinic receptor ligand, developed for the treatment of asthma. PloS one. vol 9. issue 1. 2014-11-04. PMID:24465890. |
in in vitro isometric studies, asm-024 elicited dose-dependent relaxation of isolated mouse tracheal, human, and dog bronchial preparations contracted with methacholine and guinea pig tracheas contracted with histamine. |
2014-11-04 |
2023-08-12 |
mouse |
| T Farkhondeh, M H Boskabady, S Jalali, G Bayram. The effect of lead exposure on tracheal responsiveness to methacholine and ovalbumin, total and differential white blood cells count, and serum levels of immunoglobulin E, histamine, and cytokines in guinea pigs. Human & experimental toxicology. vol 33. issue 3. 2014-09-30. PMID:23928832. |
the effect of lead exposure on tracheal responsiveness to methacholine and ovalbumin, total and differential white blood cells count, and serum levels of immunoglobulin e, histamine, and cytokines in guinea pigs. |
2014-09-30 |
2023-08-12 |
Not clear |