| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Susan T Lubejko, Giulia Livrizzi, Stanley A Buczynski, Janki Patel, Jean C Yung, Tony L Yaksh, Matthew R Banghar. Inputs to the locus coeruleus from the periaqueductal gray and rostroventral medulla shape opioid-mediated descending pain modulation. Science advances. vol 10. issue 17. 2024-04-26. PMID:38669335. |
here, we establish that noradrenergic neurons of the locus coeruleus (lc) are essential for supraspinal opioid antinociception. |
2024-04-26 |
2024-04-29 |
Not clear |
| Alessandro Galgani, Francesco Lombardo, Francesca Frijia, Nicola Martini, Gloria Tognoni, Nicola Pavese, Filippo Sean Giorg. The degeneration of locus coeruleus occurring during Alzheimer's disease clinical progression: a neuroimaging follow-up investigation. Brain structure & function. 2024-04-16. PMID:38625557. |
the noradrenergic nucleus locus coeruleus (lc) is precociously involved in alzheimer's disease (ad) pathology, and its degeneration progresses during the course of the disease. |
2024-04-16 |
2024-04-18 |
Not clear |
| Irene Suárez-Pereira, Carolina López-Martín, Carmen Camarena-Delgado, Meritxell Llorca-Torralba, Francisco González-Saiz, Rocío Ruiz, Martiniano Santiago, Esther Berrocos. Nerve injury triggers time-dependent activation of the locus coeruleus, influencing spontaneous pain-like behavior in rats. Anesthesiology. 2024-04-11. PMID:38602502. |
dynamic changes in neuronal activity and in noradrenergic locus coeruleus (lc) projections have been proposed during the transition from acute to chronic pain. |
2024-04-11 |
2024-04-13 |
rat |
| Jingyun Lee, Zhong-Min Wang, María Laura Messi, Carol Milligan, Cristina M Furdui, Osvaldo Delbon. Sex differences in single neuron function and proteomics profiles examined by patch-clamp and mass spectrometry in the locus coeruleus of the adult mouse. Acta physiologica (Oxford, England). 2024-03-09. PMID:38459766. |
this study aimed to characterize the properties of locus coeruleus (lc) noradrenergic neurons in male and female mice. |
2024-03-09 |
2024-03-11 |
mouse |
| Kandatege Wimalasena, Oluwatosin Adetuyi, Maya Eldan. Metabolic energy decline coupled dysregulation of catecholamine metabolism in physiologically highly active neurons: implications for selective neuronal death in Parkinson's disease. Frontiers in aging neuroscience. vol 16. 2024-03-07. PMID:38450382. |
two main pathophysiological features of pd are the accumulation of inclusion bodies in the affected neurons and the predominant loss of neuromelanin-containing da neurons in substantia nigra pars compacta (snpc) and noradrenergic (ne) neurons in locus coeruleus (lc). |
2024-03-07 |
2024-03-09 |
Not clear |
| Yayun Yan, Mengchao Zhang, Wenhua Ren, Xiaoqi Zheng, Ying Chan. Neuromelanin-sensitive magnetic resonance imaging: Possibilities and promises as an imaging biomarker for Parkinson's disease. The European journal of neuroscience. 2024-03-05. PMID:38441250. |
parkinson's disease (pd) is an age-related progressive neurodegenerative disorder characterized by both motor and non-motor symptoms resulting from the death of dopaminergic neurons in the substantia nigra pars compacta (snpc) and noradrenergic neurons in the locus coeruleus (lc). |
2024-03-05 |
2024-03-07 |
Not clear |
| Alex I Wiesman, Victoria Madge, Edward A Fon, Alain Dagher, D Louis Collins, Sylvain Baille. Associations between neuromelanin depletion and cortical rhythmic activity in Parkinson's disease. medRxiv : the preprint server for health sciences. 2024-02-26. PMID:38405952. |
parkinson's disease (pd) is marked by the death of neuromelanin-rich dopaminergic and noradrenergic cells in the substantia nigra (sn) and the locus coeruleus (lc), respectively, resulting in motor and cognitive impairments. |
2024-02-26 |
2024-02-28 |
Not clear |
| Charles Rodenkirch, Qi Wan. Optimization of Temporal Coding of Tactile Information in Rat Thalamus by Locus Coeruleus Activation. Biology. vol 13. issue 2. 2024-02-23. PMID:38392298. |
the brainstem noradrenergic nucleus, the locus coeruleus (lc), exerts heavy influences on sensory processing, perception, and cognition through its diffuse projections throughout the brain. |
2024-02-23 |
2024-02-25 |
rat |
| Marcelo Mendonça-Dos-Santos, Thaís Cristina Teixeira Gonçalves, Luiz Luciano Falconi-Sobrinho, Tayllon Dos Anjos-Garcia, Ivair Matias, Rithiele Cristina de Oliveira, Maria de Fátima Dos Santos Sampaio, Fabrízio Dos Santos Cardoso, Wagner Ferreira Dos Santos, Helio Rubens Machado, Norberto Cysne Coimbr. GABAergic and glutamatergic inputs to the medulla oblongata and locus coeruleus noradrenergic pathways are critical for seizures and postictal antinociception neuromodulation. Scientific reports. vol 14. issue 1. 2024-02-20. PMID:38374419. |
we investigated the participation of the nucleus of the tractus solitarius (nts) in tonic‒clonic seizures and postictal antinociception control mediated by nmda receptors, the role of nts gabaergic interneurons and noradrenergic pathways from the locus coeruleus (lc) in these phenomena. |
2024-02-20 |
2024-02-22 |
rat |
| Stephanie L Grella, Tia N Donaldso. Contextual memory engrams, and the neuromodulatory influence of the locus coeruleus. Frontiers in molecular neuroscience. vol 17. 2024-02-20. PMID:38375501. |
we then outline a recent hypothesis involving noradrenergic and dopaminergic projections from the locus coeruleus (lc) to different subregions of the hippocampus, in sculpting contextual representations, giving a brief description of the neuroanatomical and physiological properties of the lc. |
2024-02-20 |
2024-02-22 |
Not clear |
| Claire Terrier, Juliette Greco-Vuilloud, Matthias Cavelius, Marc Thevenet, Nathalie Mandairon, Anne Didier, Marion Richar. Long-term olfactory enrichment promotes non-olfactory cognition, noradrenergic plasticity and remodeling of brain functional connectivity in older mice. Neurobiology of aging. vol 136. 2024-02-16. PMID:38364691. |
taking advantage of the ability of olfactory stimulation to activate noradrenergic neurons of the locus coeruleus, we used repeated olfactory enrichment sessions over the mouse lifespan to enable the cognitive reserve buildup. |
2024-02-16 |
2024-02-19 |
mouse |
| Milica Milicic, Balázs Gaszner, Gergely Berta, Erika Pintér, Viktória Kormo. The Lack of TRPA1 Ion Channel Does Not Affect the Chronic Stress-Induced Activation of the Locus Ceruleus. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339042. |
the noradrenergic locus ceruleus (lc) is also an important player in mood control. |
2024-02-10 |
2024-02-12 |
mouse |
| Chen-Pei Lin, Irene Frigerio, John G J M Bol, Maud M A Bouwman, Alex J Wesseling, Martin J Dahl, Annemieke J M Rozemuller, Ysbrand D van der Werf, Petra J W Pouwels, Wilma D J van de Berg, Laura E Jonkma. Microstructural integrity of the locus coeruleus and its tracts reflect noradrenergic degeneration in Alzheimer's disease and Parkinson's disease. Translational neurodegeneration. vol 13. issue 1. 2024-02-09. PMID:38336865. |
microstructural integrity of the locus coeruleus and its tracts reflect noradrenergic degeneration in alzheimer's disease and parkinson's disease. |
2024-02-09 |
2024-02-12 |
Not clear |
| Chen-Pei Lin, Irene Frigerio, John G J M Bol, Maud M A Bouwman, Alex J Wesseling, Martin J Dahl, Annemieke J M Rozemuller, Ysbrand D van der Werf, Petra J W Pouwels, Wilma D J van de Berg, Laura E Jonkma. Microstructural integrity of the locus coeruleus and its tracts reflect noradrenergic degeneration in Alzheimer's disease and Parkinson's disease. Translational neurodegeneration. vol 13. issue 1. 2024-02-09. PMID:38336865. |
degeneration of the locus coeruleus (lc) noradrenergic system contributes to clinical symptoms in alzheimer's disease (ad) and parkinson's disease (pd). |
2024-02-09 |
2024-02-12 |
Not clear |
| Qiuyu Lv, Xuanyi Wang, Pan Lin, Xiang Wan. Neuromelanin-sensitive magnetic resonance imaging in the study of mental disorder: A systematic review. Psychiatry research. Neuroimaging. vol 339. 2024-02-07. PMID:38325165. |
recent research suggests that neuromelanin-sensitive magnetic resonance imaging (nm-mri) techniques may overcome this limitation by enabling the non-invasive imaging of the substantia nigra (sn)/ ventral tegmental area (vta) dopaminergic and locus coeruleus (lc) noradrenergic systems. |
2024-02-07 |
2024-02-10 |
Not clear |
| Ana Perez-Villalba, María Salomé Sirerol-Piquer, Raúl Soriano-Cantón, Virginia Folgado, Azucena Pérez-Cañamás, Martina Kirstein, Isabel Fariñas, Francisco Pérez-Sánche. Dopaminergic neuron loss in mice due to increased levels of wild-type human α-Synuclein only takes place under conditions of accelerated aging. Scientific reports. vol 14. issue 1. 2024-01-30. PMID:38291230. |
these motor disturbances correlate with reduced dopamine (da) levels, increased da turnover, synaptic terminal loss, and notably, the depletion of dopaminergic neurons in the substantia nigra and noradrenergic neurons in the locus coeruleus. |
2024-01-30 |
2024-02-02 |
mouse |
| Marta Louçano, Ana Coelho, Sílvia Sousa Chambel, Cristina Prudêncio, Célia Duarte Cruz, Isaura Tavare. Noradrenergic Pathways Involved in Micturition in an Animal Model of Hydrocephalus-Implications for Urinary Dysfunction. Biomedicines. vol 12. issue 1. 2024-01-23. PMID:38255319. |
although the underlying etiology is not fully described, the effects of hydrocephalus in the neuronal network responsible for the control of urination, which involves periventricular areas, including the periaqueductal gray (pag) and the noradrenergic locus coeruleus (lc). |
2024-01-23 |
2024-01-25 |
rat |
| Cora E Smiley, Brittany S Pate, Samantha J Bouknight, Evelynn N Harrington, Aaron M Jasnow, Susan K Woo. The role of locus coeruleus neuroimmune signaling in the response to social stress in female rats. bioRxiv : the preprint server for biology. 2024-01-23. PMID:38260568. |
our previous work established that females selectively exhibit increased proinflammatory cytokine release within the noradrenergic locus coeruleus (lc) in response to witnessing social stress, which was associated with a hypervigilant phenotype. |
2024-01-23 |
2024-01-25 |
rat |
| Bedia Samanci, Sonny Tan, Stijn Michielse, Mark L Kuijf, Yasin Teme. THE HABENULA IN PARKINSON'S DISEASE: ANATOMY, FUNCTION, AND IMPLICATIONS FOR MOOD DISORDERS - A NARRATIVE REVIEW. Journal of chemical neuroanatomy. 2024-01-18. PMID:38237746. |
additionally, the locus coeruleus and its noradrenergic neurons are among the first areas to degenerate in pd and contribute to stress, emotional memory, motor, sensory, and autonomic symptoms. |
2024-01-18 |
2024-01-21 |
Not clear |
| Giovanni Palermo, Alessandro Galgani, Gabriele Bellini, Francesco Lombardo, Nicola Martini, Riccardo Morganti, Davide Paoli, Sara De Cori, Francesca Frijia, Gabriele Siciliano, Roberto Ceravolo, Filippo Sean Giorg. Neurogenic orthostatic hypotension in Parkinson's disease: is there a role for locus coeruleus magnetic resonance imaging? Journal of neural transmission (Vienna, Austria : 1996). vol 131. issue 2. 2024-01-16. PMID:38032367. |
locus coeruleus (lc) is the main noradrenergic nucleus of the brain, and degenerates early in parkinson's disease (pd). |
2024-01-16 |
2024-01-18 |
human |