| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yijing Zhou, Vanessa B Sanchez, Peining Xu, Thomas Roule, Marco Flores-Mendez, Brianna Ciesielski, Donna Yoo, Hiab Teshome, Teresa Jimenez, Shibo Liu, Mike Henne, Tim O'Brien, Ye He, Clementina Mesaros, Naiara Akiz. Altered lipid homeostasis is associated with cerebellar neurodegeneration in SNX14 deficiency. JCI insight. 2024-04-16. PMID:38625743. |
we demonstrate that cerebellar purkinje cells (pcs) are selectively vulnerable to snx14 deficiency while forebrain regions preserve their neuronal content. |
2024-04-16 |
2024-04-18 |
mouse |
| Christopher H Chen, Leannah N Newman, Amanda P Stark, Katherine E Bond, Dawei Zhang, Stefano Nardone, Charles R Vanderburg, Naeem M Nadaf, Zhiyi Yao, Kefiloe Mutume, Isabella Flaquer, Bradford B Lowell, Evan Z Macosko, Wade G Regeh. A Purkinje cell to parabrachial nucleus pathway enables broad cerebellar influence over the forebrain. Nature neuroscience. vol 26. issue 11. 2023-11-03. PMID:37919612. |
we found that suppressing the firing of cerebellar purkinje cells (pcs) rapidly excites forebrain areas that contribute to such functions (including the amygdala, basal forebrain and septum), but that the classic cerebellar outputs, the deep cerebellar nuclei, do not directly project there. |
2023-11-03 |
2023-11-08 |
Not clear |
| Anastasia Rumyantseva, Milica Popovic, Aleksandra Trifunovi. CLPP deficiency ameliorates neurodegeneration caused by impaired mitochondrial protein synthesis. Brain : a journal of neurology. 2022-03-03. PMID:35240691. |
here, we build upon this finding by showing that clpp depletion is indeed beneficial in vivo for various types of neuronal populations, including purkinje cells in the cerebellum and cortical and hippocampal neurons in the forebrain, as it strongly improves distinct phenotypes of mitochondria encephalopathy, driven by the deficiency of the mitochondrial aspartyl trna synthase dars2. |
2022-03-03 |
2023-08-13 |
mouse |
| Anastasia Rumyantseva, Milica Popovic, Aleksandra Trifunovi. CLPP deficiency ameliorates neurodegeneration caused by impaired mitochondrial protein synthesis. Brain : a journal of neurology. 2022-03-03. PMID:35240691. |
this in turn leads to a decreased neuroinflammatory response and significantly improved motor functions in both double-deficient models (purkinje cell-specific or forebrain neuron-specific dars2/clpp double knockout mice). |
2022-03-03 |
2023-08-13 |
mouse |
| Lilla E Szabó, G Mark Marcello, Miklós Süth, Péter Sótonyi, Bence Rác. Distribution of cortactin in cerebellar Purkinje cell spines. Scientific reports. vol 11. issue 1. 2021-08-09. PMID:33446758. |
spines of cerebellar purkinje cells (pcs) are plastic, but they differ from forebrain spines in a number of important respects, and the mechanisms of spine plasticity differ between forebrain and cerebellum. |
2021-08-09 |
2023-08-13 |
Not clear |
| Young Rae Jo, Hye Ran Kim, So Young Jang, Hana Go, Min-Young Song, Da Kyeong Park, Yuna Oh, Juyeon Jo, Yoon Kyung Shin, Sung Joong Lee, Sang-Myung Cheon, Hyun Kyoung Lee, Kyung Eun Lee, Young Hye Kim, Hwan Tae Par. Potential neuron-autonomous Purkinje cell degeneration by 2',3'-cyclic nucleotide 3'-phosphodiesterase promoter/Cre-mediated autophagy impairments. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 35. issue 1. 2021-06-15. PMID:33337568. |
however, in this study, using rosa26-tdtomato-reporter/cnp-cre mice, we found that many forebrain neurons and cerebellar purkinje neurons belong to the lineages of cnp-expressing neuroglial stem cells. |
2021-06-15 |
2023-08-13 |
mouse |
| Carmen Rubio, Artemio Rosiles-Abonce, Cristina Trejo-Solis, Moises Rubio-Osornio, Cesar Mendoza, Veronica Custodio, Juan C Martinez-Lazcano, Edith Gonzalez, Carlos Pa. Increase Signaling of Wnt/β-Catenin Pathway and Presence of Apoptosis in Cerebellum of Kindled Rats. CNS & neurological disorders drug targets. vol 16. issue 7. 2018-07-18. PMID:28124605. |
the purkinje cells (pc), whose axons target the dentate and interpositus nuclei, form the main cerebellar output to forebrain structures involved in epilepsy. |
2018-07-18 |
2023-08-13 |
human |
| Lisa Cole Burnett, Gabriela Hubner, Charles A LeDuc, Michael V Morabito, Jayne F Martin Carli, Rudolph L Leibe. Loss of the imprinted, non-coding Snord116 gene cluster in the interval deleted in the Prader Willi syndrome results in murine neuronal and endocrine pancreatic developmental phenotypes. Human molecular genetics. vol 26. issue 23. 2018-05-24. PMID:28973544. |
in snord116p-/m+ mice, reduced primary forebrain neuron cell body size is apparent in embryonic day 15.5 fetuses, and persists until postnatal day 30 in cerebellar purkinje neurons. |
2018-05-24 |
2023-08-13 |
mouse |
| Jordan Norwood, Jade M Franklin, Dharmendra Sharma, Santosh R D'Mell. Histone deacetylase 3 is necessary for proper brain development. The Journal of biological chemistry. vol 289. issue 50. 2015-02-12. PMID:25339172. |
in contrast, conditional knockout of hdac3 in neurons of the forebrain and certain other brain regions, using thy1-cre and calcium/calmodulin dependent protein kinase ii α-cre for ablation, produces no overt abnormalities in the organization of cells within the cortex or of cerebellar purkinje neurons at birth. |
2015-02-12 |
2023-08-13 |
mouse |
| Misato Yasumura, Tomoyuki Yoshida, Sung-Jin Lee, Takeshi Uemura, Jae-Yeol Joo, Masayoshi Mishin. Glutamate receptor δ1 induces preferentially inhibitory presynaptic differentiation of cortical neurons by interacting with neurexins through cerebellin precursor protein subtypes. Journal of neurochemistry. vol 121. issue 5. 2012-06-22. PMID:22191730. |
glutamate receptor (glur) δ1 is widely expressed in the developing forebrain, whereas glurδ2 is selectively expressed in cerebellar purkinje cells. |
2012-06-22 |
2023-08-12 |
Not clear |
| Euiseok J Kim, James Battiste, Yasushi Nakagawa, Jane E Johnso. Ascl1 (Mash1) lineage cells contribute to discrete cell populations in CNS architecture. Molecular and cellular neurosciences. vol 38. issue 4. 2009-01-06. PMID:18585058. |
ascl1 lineage cells contribute to distinct cell types in each major brain division: the forebrain including the cerebral cortex, olfactory bulb, hippocampus, striatum, hypothalamus, and thalamic nuclei, the midbrain including superior and inferior colliculi, and the hindbrain including purkinje and deep cerebellar nuclei cells and cells in the trigeminal sensory system. |
2009-01-06 |
2023-08-12 |
Not clear |
| Joshua D Bell, Jinglu Ai, Yonghong Chen, Andrew J Bake. Mild in vitro trauma induces rapid Glur2 endocytosis, robustly augments calcium permeability and enhances susceptibility to secondary excitotoxic insult in cultured Purkinje cells. Brain : a journal of neurology. vol 130. issue Pt 10. 2007-11-13. PMID:17664176. |
purkinje neurons of the cerebellum are selectively vulnerable to brain trauma, including indirect remote trauma to the forebrain. |
2007-11-13 |
2023-08-12 |
Not clear |
| Benjamin R Walker, Katia S Diefenbach, Tanvi N Parik. Inhibition within the nucleus tractus solitarius (NTS) ameliorates environmental exploration deficits due to cerebellum lesions in an animal model for autism. Behavioural brain research. vol 176. issue 1. 2007-03-01. PMID:16971000. |
saporin injections specifically targeting purkinje cells, but not after the addition of saporin-induced cholinergic forebrain lesions (experiment 2). |
2007-03-01 |
2023-08-12 |
rat |
| Yuval B Nitzan, Israel Sekler, Michal Hershfinkel, Arie Moran, William F Silverma. Postnatal regulation of ZnT-1 expression in the mouse brain. Brain research. Developmental brain research. vol 137. issue 2. 2002-11-26. PMID:12220707. |
while the parallel development of zinc and znt-1 in forebrain regions supports a direct role for synaptic zinc in regulating znt-1 expression, znt-1 in cerebellar purkinje cells could indicate that expression of this zinc transporter may also be regulated by a non-synaptic pool of zinc or by other mechanism(s). |
2002-11-26 |
2023-08-12 |
mouse |
| E Traiffort, D Charytoniuk, L Watroba, H Faure, N Sales, M Rua. Discrete localizations of hedgehog signalling components in the developing and adult rat nervous system. The European journal of neuroscience. vol 11. issue 9. 1999-11-24. PMID:10510184. |
in the adult, shh-positive cells were mainly observed in forebrain structures, in the purkinje cells of the cerebellum and in motor neurons. |
1999-11-24 |
2023-08-12 |
rat |
| A Furuta, J D Rothstein, L J Marti. Glutamate transporter protein subtypes are expressed differentially during rat CNS development. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 21. 1997-11-20. PMID:9334410. |
eaat4 had a region-specific distribution; eaat4 was mainly in cerebellum, localized to purkinje cells, with much lower levels in forebrain. |
1997-11-20 |
2023-08-12 |
rat |
| H G Knaus, C Schwarzer, R O Koch, A Eberhart, G J Kaczorowski, H Glossmann, F Wunder, O Pongs, M L Garcia, G Sper. Distribution of high-conductance Ca(2+)-activated K+ channels in rat brain: targeting to axons and nerve terminals. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 3. 1996-02-28. PMID:8558264. |
slo immunoreactivity was highly concentrated in terminal areas of prominent fiber tracts: the substantia nigra pars reticulata, globus pallidus, olfactory system, interpeduncular nucleus, hippocampal formation including mossy fibers and perforant path terminals, medial forebrain bundle and pyramidal tract, as well as cerebellar purkinje cells. |
1996-02-28 |
2023-08-12 |
rat |
| A F Struyk, P D Canoll, M J Wolfgang, C L Rosen, P D'Eustachio, J L Salze. Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 3 Pt 2. 1995-04-17. PMID:7891157. |
neurotrimin is expressed at high levels in several developing projection systems: in neurons of the thalamus, subplate, and lower cortical laminae in the forebrain and in the pontine nucleus, cerebellar granule cells, and purkinje cells in the hindbrain. |
1995-04-17 |
2023-08-12 |
mouse |
| S B Glantz, J A Amat, C S Rubi. cAMP signaling in neurons: patterns of neuronal expression and intracellular localization for a novel protein, AKAP 150, that anchors the regulatory subunit of cAMP-dependent protein kinase II beta. Molecular biology of the cell. vol 3. issue 11. 1993-01-08. PMID:1333841. |
akap 150 is abundant in purkinje cells and in neurons of the olfactory bulb, basal ganglia, cerebral cortex, and other forebrain regions. |
1993-01-08 |
2023-08-11 |
rat |
| E Kordeli, V Bennet. Distinct ankyrin isoforms at neuron cell bodies and nodes of Ranvier resolved using erythrocyte ankyrin-deficient mice. The Journal of cell biology. vol 114. issue 6. 1991-10-18. PMID:1832678. |
(b) ankyrinro missing from nb/nb mice is selectively associated with neuronal cell bodies and dendrites, excluded from myelinated axons, and displays a selective pattern of expression in the nervous system whereby expression is almost ubiquitous in neurons of the cerebellum (purkinje and granule cells) and spinal cord, and restricted to a very minor subset of neurons in hippocampus and neocortex of forebrain. |
1991-10-18 |
2023-08-11 |
mouse |