| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Unnati Jain, Priyanka Srivastava, Ashwani Sharma, Subrata Sinha, Surabhi Johar. Impaired Fibroblast Growth Factor 21 (FGF21) Associated with Visceral Adiposity Leads to Insulin Resistance: The Core Defect in Diabetes Mellitus. Current diabetes reviews. 2024-04-27. PMID:38676505. |
tumor necrosis factor alpha (tnf-α), the cytokine released by adipocytes and inflammatory cells in response to chronic inflammation, is regarded major factor that reduces the expression of fgf21 and modulates underlying insulin resistance that causes imbalanced glucose homeostasis. |
2024-04-27 |
2024-04-30 |
Not clear |
| Xiaoli Liu, Huan Zhu, Yong Peng, Yaofeng Liu, Xiangrong Sh. Twenty-Four week Taichi training improves pulmonary diffusion capacity and glycemic control in patients with Type 2 diabetes mellitus. PloS one. vol 19. issue 4. 2024-04-18. PMID:38635535. |
stepwise multiple regression analysis was applied to predict diffusion capacity of the lungs for carbon monoxide (dlco) by fasting blood glucose, insulin, glycosylated hemoglobin (hba1c), tumour necrosis factor alpha (tnf-α), von willebrand factor (vwf), interleukin-6 (il-6), intercellular adhesion molecule 1 (icam-1), endothelial nitric oxide synthase (enos), nitric oxide (no), endothelin-1 (et-1), vascular endothelial growth factor, and prostaglandin i-2. |
2024-04-18 |
2024-04-21 |
Not clear |
| Alessandro D Genazzani, Christian Battipaglia, Laura Rusce, Greta Prampolini, Claudia Aio, Francesco Ricciardiello, Martina Foschi, Alessandra Sponzilli, Elisa Semprini, Tabatha Petrill. Alpha lipoic acid administration improved both peripheral sensitivity to insulin and liver clearance of insulin reducing potential risk of diabetes and nonalcoholic fatty liver disease in overweight/obese PCOS patients. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. vol 40. issue 1. 2024-04-16. PMID:38622970. |
alpha lipoic acid administration improved both peripheral sensitivity to insulin and liver clearance of insulin reducing potential risk of diabetes and nonalcoholic fatty liver disease in overweight/obese pcos patients. |
2024-04-16 |
2024-04-18 |
Not clear |
| Glyn M Noguchi, Vincent C Castillo, Cynthia J Donaldson, Marcus R Flisher, Ariana T Momen, Alan Saghatelian, Mark O Huisin. Urocortin3 contributes to paracrine inhibition of islet alpha cells in mice. The Journal of endocrinology. 2024-04-09. PMID:38593829. |
ucn3 thus inhibits insulin secretion via a negative feedback loop with delta cells, but its role with respect to alpha cells and glucagon secretion is not understood. |
2024-04-09 |
2024-04-12 |
mouse |
| Lingfeng Tong, Zhangbing Chen, Yangyang Li, Xinxia Wang, Changjie Yang, Yakui Li, Yemin Zhu, Ying Lu, Qi Liu, Nannan Xu, Sijia Shao, Lifang Wu, Ping Zhang, Guangyu Wu, Xiaoyu Wu, Xiaosong Chen, Junwei Fang, Renbing Jia, Tianle Xu, Bin Li, Liang Zheng, Junling Liu, Xuemei Ton. Transketolase promotes MAFLD by limiting inosine-induced mitochondrial activity. Cell metabolism. 2024-03-28. PMID:38547864. |
hyperinsulinemia promoted tkt expression through the insulin receptor-ccaat/enhancer-binding protein alpha axis. |
2024-03-28 |
2024-03-31 |
mouse |
| Gabriela M Soares, Sandra L Balbo, Gabriela A Bronczek, Jean F Vettorazzi, Carine Marmentini, Lucas Zangerolamo, Licio A Velloso, Everardo M Carneir. Vertical sleeve gastrectomy improves glucose-insulin homeostasis by enhancing beta cell function and survival via FGF15/19. American journal of physiology. Endocrinology and metabolism. 2023-12-20. PMID:38117265. |
using a diet-induced obese mice model, we demonstrate that vsg attenuates insulin hypersecretion in isolated pancreatic islets, likely due to morphological alterations in the endocrine pancreas such as reduction in islet, beta cell, and alpha cell mass. |
2023-12-20 |
2023-12-23 |
mouse |
| Lía Nattero-Chávez, Jorge Bondía, Héctor F Escobar-Morreale, Manuel Luque-Ramíre. Closed-loop systems in Type 1 diabetes and antitumor necrosis factor alpha therapy: Are currently available algorithms prepared for sudden changes in insulin sensitivity? Journal of diabetes. 2023-12-19. PMID:38112621. |
closed-loop systems in type 1 diabetes and antitumor necrosis factor alpha therapy: are currently available algorithms prepared for sudden changes in insulin sensitivity? |
2023-12-19 |
2023-12-23 |
Not clear |
| Tiffany M Richardson, Yasminye D Pettway, John T Walker, Heather A Nelson, Matthew Ishahak, Gregory Poffenberger, Radhika Aramandla, Conrad Reihsmann, Ashutosh Agarwal, Alvin C Powers, Marcela Brissov. Human Pseudoislet System for Synchronous Assessment of Fluorescent Biosensor Dynamics and Hormone Secretory Profiles. Journal of visualized experiments : JoVE. issue 201. 2023-11-20. PMID:37982512. |
the pancreatic islets of langerhans, which are small 3d collections of specialized endocrine and supporting cells interspersed throughout the pancreas, have a central role in the control of glucose homeostasis through the secretion of insulin by beta cells, which lowers blood glucose, and glucagon by alpha cells, which raises blood glucose. |
2023-11-20 |
2023-11-29 |
human |
| Manu Aggarwal, Deborah A Striegel, Manami Hara, Vipul Periwa. Geometric and topological characterization of the cytoarchitecture of islets of Langerhans. PLoS computational biology. vol 19. issue 11. 2023-11-09. PMID:37943957. |
insulin and glucagon, secreted by beta and alpha cells, respectively, are responsible for metabolic switching between fat and glucose utilization. |
2023-11-09 |
2023-11-20 |
Not clear |
| Shahanaj Ismail, Tajalli Ilm Chandel, Jaganathan Ramakrishnan, Rizwan Hasan Khan, Kumaradhas Poomani, Natarajan Devaraja. Phytochemical profiling, human insulin stability and alpha glucosidase inhibition of Gymnema latifolium leaves aqueous extract: Exploring through experimental and in silico approach. Computational biology and chemistry. vol 107. 2023-10-11. PMID:37820470. |
phytochemical profiling, human insulin stability and alpha glucosidase inhibition of gymnema latifolium leaves aqueous extract: exploring through experimental and in silico approach. |
2023-10-11 |
2023-10-15 |
human |
| Samnhita Raychaudhuri, Md Shahinozzaman, Si Fan, Opeyemi Ogedengbe, Ujjwol Subedi, Diana N Oband. Resistance to Diet Induced Visceral Fat Accumulation in C57BL/6NTac Mice Is Associated with an Enriched Lactococcus in the Gut Microbiota and the Phenotype of Immune B Cells in Intestine and Adipose Tissue. Microorganisms. vol 11. issue 9. 2023-09-28. PMID:37763997. |
the op mice with higher fat accumulation and insulin resistance harbored microbial communities with enhanced capacity for processing dietary sugars, lower alpha diversity, greater abundance of lactobacilli and low abundance of clostridia and desulfobacterota. |
2023-09-28 |
2023-10-07 |
mouse |
| Melpomeni Moustaki, Stavroula A Paschou, Elena Vakali, Paraskevi Xekouki, Georgia Ntali, Evanthia Kassi, Melpomeni Peppa, Theodora Psaltopoulou, Marinella Tzanela, Andromachi Vryonido. Secondary diabetes mellitus in pheochromocytomas and paragangliomas. Endocrine. 2023-09-21. PMID:37731140. |
the fact that surgical treatment of ppgls restores insulin sensitivity and secretion at greater extent compared to alpha and beta blockade, implies the existence of further, non-adrenergic mechanisms, possibly involving other hormonal co-secretion by these tumors. |
2023-09-21 |
2023-10-07 |
Not clear |
| Bibi Uhre Nielsen, Inger Hee Mabuza Mathiesen, Rikke Møller, Rikke Krogh-Madsen, Terese Lea Katzenstein, Tacjana Pressler, James A M Shaw, Christian Ritz, Michael R Rickels, Darko Stefanovski, Thomas Peter Almdal, Daniel Faurholt-Jepse. Characterization of impaired beta and alpha cell function in response to an oral glucose challenge in cystic fibrosis: a cross-sectional study. Frontiers in endocrinology. vol 14. 2023-09-18. PMID:37720541. |
hence, we aimed to describe and compare beta cell function (insulin and proinsulin) and alpha cell function (glucagon) in relation to glucose tolerance in adults with cf and to study whether hypoglycaemia following oral glucose challenge may represent an early sign of islet cell impairment. |
2023-09-18 |
2023-10-07 |
Not clear |
| Prisca K Lin, Gretchen M Koller, George E Davi. Elucidating the morphogenic and signaling roles of defined growth factors controlling human endothelial cell lumen formation versus sprouting behavior. The American journal of pathology. 2023-09-09. PMID:37689384. |
insulin, fibroblast growth factor-2 (fgf-2), stem cell factor (scf), interleukin-3 (il-3), and stromal-derived factor-1 alpha (sdf-1α)] in combination are necessary for human ecs to undergo tube morphogenesis, a process requiring both lumen formation and sprouting behavior. |
2023-09-09 |
2023-10-07 |
human |
| Xiue Wei, Wenhua Che, Qiufeng Wang, Lili Y. Evaluation of adiponectin and TNF-α expression in diabetic patients and its relationship with cardiovascular diseases. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 5. 2023-08-12. PMID:37571897. |
tumor necrosis factor alpha (tnf-α), a pro-inflammatory cytokine secreted from the tissue on the insulin signaling pathway, can play a role in causing fat resistance to insulin in type 2 diabetes patients. |
2023-08-12 |
2023-08-16 |
human |
| John D Douglass, Kelly M Ness, Martin Valdearcos, Alice Wyse-Jackson, Mauricio D Dorfman, Jeremy M Frey, Rachael D Fasnacht, Olivia D Santiago, Anzela Niraula, Jineta Banerjee, Megan Robblee, Suneil K Koliwad, Joshua P Thale. Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance. Cell metabolism. 2023-08-12. PMID:37572666. |
microglial regulation of glucose homeostasis involves a tumor necrosis factor alpha (tnf-α)-dependent mechanism that increases activation of pro-opiomelanocortin (pomc) and other hypothalamic glucose-sensing neurons, ultimately leading to a marked amplification of first-phase insulin secretion via a parasympathetic pathway. |
2023-08-12 |
2023-08-16 |
Not clear |
| Shaimaa Nasr Amin, Fida Asali, Iman Aolymat, Dua Abuquteish, Ola Abu Al Karsaneh, Walaa Bayoumie El Gazzar, Sherif Ahmed Shaltout, Yasmeen Jamal Alabdallat, Dalia Azmy Elberry, Samaa Samir Kamar, Sara Adel Hosny, Marwa Nagi Mehesen, Laila Ahmed Rashed, Ayman Mohamed Farag, Asmaa Mohammed ShamsEldee. Comparing MitoQ10 and heat therapy: Evaluating mechanisms and therapeutic potential for polycystic ovary syndrome induced by circadian rhythm disruption. Chronobiology international. 2023-08-07. PMID:37548004. |
furthermore, both interventions improved the elevated serum levels of anti-mullerian hormone (amh), kisspeptin, fibulin-1, a disintegrin and metalloproteinase with thrombospondin motifs 19 (adamts-19), lipid profile, homeostatic model assessment for insulin resistance (homa-ir), oxidative stress markers, androgen receptors (ar) and their transcription target genes, fkbp52 immunostaining in ovarian tissues, and uterine estrogen receptor alpha (er-α) and primmunostaining. |
2023-08-07 |
2023-08-14 |
rat |
| Sarah L Armour, Jade E Stanley, James Cantley, E Danielle Dean, Jakob G Knudse. Metabolic regulation of glucagon secretion. The Journal of endocrinology. 2023-07-31. PMID:37523232. |
since the discovery of glucagon 100 years ago, the hormone, and the pancreatic islet alpha cells that produce it, have remained enigmatic relative to insulin producing beta cells. |
2023-07-31 |
2023-08-14 |
Not clear |
| Yu-Te Yeh, Chandan Sona, Xin Yan, Yunxiao Li, Adrija Pathak, Mark I McDermott, Zhigang Xie, Liangwen Liu, Anoop Arunagiri, Yuting Wang, Amaury Cazenave-Gassiot, Adhideb Ghosh, Ferdinand von Meyenn, Sivarajan Kumarasamy, Sonia M Najjar, Shiqi Jia, Markus R Wenk, Alexis Traynor-Kaplan, Peter Arvan, Sebastian Barg, Vytas A Bankaitis, Matthew N Po. Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction. Nature communications. vol 14. issue 1. 2023-07-17. PMID:37460527. |
phosphatidylinositol transfer protein alpha (pitpna) stimulates activity of phosphatidylinositol (ptdins) 4-oh kinase to produce sufficient ptdins-4-phosphate (ptdins-4-p) in the trans-golgi network to promote insulin granule maturation. |
2023-07-17 |
2023-08-14 |
human |
| Reza Ataei Kachouei, Alireza Doagoo, Maral Jalilzadeh, Seyyed Hossein Khatami, Shima Rajaei, Ali Jahanbazi Jahan-Abad, Farzaneh Salmani, Roya Pakrad, Somayeh Mahmoodi Baram, Mitra Nourbakhsh, Mohammad-Amin Abdollahifar, Hojjat Allah Abbaszadeh, Shokoofeh Noori, Mitra Rezaei, Meisam Mahdavi, Mohammad Reza Shahmohammadi, Saeed Karim. Acetyl-11-Keto-Beta-Boswellic Acid Has Therapeutic Benefits for NAFLD Rat Models That Were Given a High Fructose Diet by Ameliorating Hepatic Inflammation and Lipid Metabolism. Inflammation. 2023-06-13. PMID:37310644. |
at the end of the study, various parameters were analyzed including liver tissues and serum levels of insulin, leptin, adiponectin, monocyte chemoattractant protein-1 (mcp-1), transforming growth factor beta (tgf-β), interferon gamma (inf-ϒ), interleukin-6 (il-6), and tumor necrosis factor alpha (tnf-α). |
2023-06-13 |
2023-08-14 |
rat |