| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kyrah M Thumbadoo, Birger V Dieriks, Helen C Murray, Molly E V Swanson, Ji Hun Yoo, Nasim F Mehrabi, Clinton Turner, Michael Dragunow, Richard L M Faull, Maurice A Curtis, Teepu Siddique, Christopher E Shaw, Kathy L Newell, Lyndal Henden, Kelly L Williams, Garth A Nicholson, Emma L Scotte. Hippocampal aggregation signatures of pathogenic UBQLN2 in amyotrophic lateral sclerosis and frontotemporal dementia. Brain : a journal of neurology. 2024-05-04. PMID:38703371. |
pathogenic variants in the ubqln2 gene cause x-linked dominant amyotrophic lateral sclerosis and/or frontotemporal dementia characterised by ubiquilin 2 aggregates in neurons of the motor cortex, hippocampus, and spinal cord. |
2024-05-04 |
2024-05-07 |
Not clear |
| Alex Kafkas, Andrew R Mayes, Daniela Montald. The hippocampus supports the representation of abstract concepts: Implications for the study of recognition memory. Neuropsychologia. 2024-05-02. PMID:38697557. |
interestingly, word recollection produced hippocampal activation regardless of word content, while the parahippocampal cortex was sensitive to concreteness of word representations, regardless of memory outcome. |
2024-05-02 |
2024-05-05 |
human |
| Dan Huang, Yunhui Fan, Jingjun Zhang, Qianfeng Wang, Ming Ding, Ruiqing Hou, Kewei Yu, Xiao Xiao, Yi Wu, Junfa W. Dorsal dentate gyrus mediated enriched environment-induced anxiolytic and antidepressant effects in cortical infarcted mice. Experimental neurology. 2024-04-30. PMID:38685308. |
compared to the mice housing in a standard environment, those subjected to acute ee stimulation had significantly increased alff and reho values in the bilateral somatosensory cortex (s1, s2), dorsal dentate gyrus (ddg), dorsal ca1 of hippocampus (dca1), lateral habenular nucleus (lhb), periaqueductal gray (pag), ipsilateral primary motor cortex (m1), retrosplenial cortex (rsc), parietal association cortex (pta), dorsal ca3 of hippocampus (dca3), claustrum (cl), ventral pallidum (vp), amygdala (amy), and contralateral auditory cortex (au). |
2024-04-30 |
2024-05-03 |
mouse |
| Sukriti Vishwas, Bushra Bashir, Devendra Birla, Nikhil Khandale, Motamarri Venkata Naga Lalitha Chaitanya, Dinesh Kumar Chellappan, Gaurav Gupta, Poonam Negi, Kamal Dua, Sachin Kumar Sing. Neuroprotective Role of Phytoconstituents-based Nanoemulsion for the Treatment of Alzheimer's Disease. Current topics in medicinal chemistry. 2024-04-27. PMID:38676489. |
presently, various phytomedicines and their bioactive compounds have been identified for their neuroprotective effects in reducing oxidative stress, alleviating neuroinflammation, and mitigating the accumulation of aβ and acetylcholinesterase enzymes in the hippocampus and cerebral cortex regions of the brain. |
2024-04-27 |
2024-04-30 |
mouse |
| Ratchaniporn Kongsui, Jinatta Jittiwa. Biomedical reports. vol 20. issue 6. 2024-04-26. PMID:38665422. |
the results indicated that 6-gingerol treatment for a duration of 7 days reverses morphological alterations, enhances catalase and glutathione peroxidase activities, reduces bax, caspase-3 and mapk expression, and increases bcl-xl and mfn2 expression in the cortex and hippocampus. |
2024-04-26 |
2024-04-28 |
rat |
| Josephin Wagner, Lauren M Park, Partha Mukhopadhyay, Csaba Matyas, Eszter Trojnar, Ruslan Damadzic, Jeesun Jung, Andrew S Bell, Lucas A Mavromatis, Ali M Hamandi, Daniel B Rosoff, Leandro F Vendruscolo, George F Koob, Pal Pacher, Falk W Lohof. PCSK9 inhibition attenuates alcohol-associated neuronal oxidative stress and cellular injury. Brain, behavior, and immunity. vol 119. 2024-04-25. PMID:38657842. |
alirocumab also mitigated ethanol-induced microglia recruitment in the cortex and hippocampus (iba1). |
2024-04-25 |
2024-04-28 |
rat |
| Charlotte S Herber, Karishma J B Pratt, Jeremy M Shea, Saul A Villeda, Lisa M Giocom. Spatial Coding Dysfunction and Network Instability in the Aging Medial Entorhinal Cortex. bioRxiv : the preprint server for biology. 2024-04-25. PMID:38659809. |
across species, spatial memory declines with age, possibly reflecting altered hippocampal and medial entorhinal cortex (mec) function. |
2024-04-25 |
2024-04-28 |
Not clear |
| Aya Hassouneh, Bradley Bazuin, Alessander Danna-Dos-Santos, Ilgin Acar, Ikhlas Abdel-Qade. Feature Importance Analysis and Machine Learning for Alzheimer's Disease Early Detection: Feature Fusion of the Hippocampus, Entorhinal Cortex, and Standardized Uptake Value Ratio. Digital biomarkers. vol 8. issue 1. 2024-04-23. PMID:38650695. |
feature importance analysis and machine learning for alzheimer's disease early detection: feature fusion of the hippocampus, entorhinal cortex, and standardized uptake value ratio. |
2024-04-23 |
2024-04-26 |
Not clear |
| Jit Poddar, Suresh B Rangasamy, Kalipada Paha. Therapeutic efficacy of cinnamein, a component of balsam of Tolu/Peru, in controlled cortical impact mouse model of TBI. Neurochemistry international. 2024-04-19. PMID:38641028. |
oral delivery of cinnamein through gavage brought down the activation of microglia and astrocytes to decrease the expression of inducible nitric oxide synthase (inos), glial fibrillary acidic protein (gfap) and ionized calcium binding adaptor molecule 1 (iba1) in hippocampus and cortex of tbi mice. |
2024-04-19 |
2024-04-22 |
mouse |
| Komal Bhandari, Harsh Kanodia, Flavio Donato, Pico Caron. Selective vulnerability of the ventral hippocampus-prelimbic cortex axis parvalbumin interneuron network underlies learning deficits of fragile X mice. Cell reports. vol 43. issue 5. 2024-04-17. PMID:38630591. |
by contrast, the functional axis linking the ventral hippocampus (vh) to the prelimbic cortex (prel) is selectively affected in constitutive fmr1y/- mice. |
2024-04-17 |
2024-04-20 |
mouse |
| Eliza M Greiner, Gorica D Petrovic. Recruitment of hippocampal and thalamic pathways to the central amygdala in the control of feeding behavior under novelty. Brain structure & function. 2024-04-16. PMID:38625554. |
recruitment of direct inputs from the paraventricular nucleus of the thalamus (pvt), the infralimbic cortex (ila), the agranular insular cortex (ai), the hippocampal ventral field ca1, and the bed nucleus of the stria terminals (bst) was assessed with combined retrograde tract tracing and fos induction analysis. |
2024-04-16 |
2024-04-18 |
rat |
| Ji-Yong Liu, Wen-Li Zhang, Jun Liao, Li-Juan Hu, Guo-Zuo Wang, Jin-Wen Ge, Zhi-Gang Me. [Effect of Naotaifang on microglial polarization and glial scar following cerebral ischemia reperfusion injury]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 4. 2024-04-15. PMID:38621906. |
compared with the sham, model 7 d and model 14 d groups showed cerebral infarction of different degrees, severe pathological injury of cerebral cortex and hippocampus, neurological impairment, reduced spatial learning and memory, cognitive dysfunction, severe anxiety, astrocyte hyperplasia, thickening penumbra glial scar, and up-regulated protein levels of il-1β, il-6, gfap, neurocan, phosphacan, cd206, and arg-1(p<0.01). |
2024-04-15 |
2024-04-18 |
rat |
| Paola Rocca, Claudio Brasso, Cristiana Montemagni, Elisa Del Favero, Silvio Bellino, Paola Bozzatello, Giulia Maria Giordano, Edoardo Caporusso, Leonardo Fazio, Giulio Pergola, Giuseppe Blasi, Mario Amore, Pietro Calcagno, Rodolfo Rossi, Alessandro Rossi, Alessandro Bertolino, Silvana Galderisi, Mario Ma. The relationship between the resting state functional connectivity and social cognition in schizophrenia: Results from the Italian Network for Research on Psychoses. Schizophrenia research. vol 267. 2024-04-13. PMID:38613864. |
we found five significant differences between sz patients and hvs: in the patients' group, the correlations between emotion recognition tasks and rsfc of the right entorhinal cortex (r-ec), left superior parietal lobule (l-spl), right caudal hippocampus (r-c-hipp), and the right caudal (r-c) and left rostral (l-r) middle temporal gyri (mtg) were lost. |
2024-04-13 |
2024-04-16 |
human |
| Punya Sachdeva, Kannan Badri Narayanan, Jitendra Kumar Sinha, Saurabh Gupta, Shampa Ghosh, Krishna Kumar Singh, Rakesh Bhaskar, Abdulmajeed G Almutary, James H Zothantluanga, Kranthi Kumar Kotta, Vinod Kumar Nelson, Ana Cláudia Paiva-Santos, Mosleh Mohammad Abomughaid, Mehnaz Kamal, Danish Iqbal, Mohammed Hamoud ALHarbi, Awadh Aedh ALMutairi, Saikat Dewanjee, Mohana Vamsi Nuli, Shanmugam Vippamakula, Saurabh Kumar Jha, Shreesh Ojha, Niraj Kumar Jh. Recent Advances in Drug Delivery Systems Targeting Insulin Signalling for the Treatment of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2024-04-12. PMID:38607755. |
insulin and the downstream insulin signaling molecules are found mainly in the hippocampus and cortex. |
2024-04-12 |
2024-04-15 |
Not clear |
| Neda Shafiee, Vladimir Fonov, Mahsa Dadar, R Nathan Spreng, D Louis Collin. Degeneration in Nucleus basalis of Meynert signals earliest stage of Alzheimer's disease progression. Neurobiology of aging. vol 139. 2024-04-12. PMID:38608458. |
nucleus basalis of meynert (nbm), a crucial source of cholinergic projection to the entorhinal cortex (ec) and hippocampus (hc), has shown sensitivity to neurofibrillary degeneration in the early stages of alzheimer's disease. |
2024-04-12 |
2024-04-15 |
human |
| Maciej Zadrozny, Patrycja Drapich, Anna Gasiorowska-Bien, Wiktor Niewiadomski, Charles R Harrington, Claude M Wischik, Gernot Riedel, Grazyna Niewiadomsk. Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model. Cells. vol 13. issue 7. 2024-04-12. PMID:38607082. |
the strongest phenotypic reversal coincided with a normalization of the tau load in the cortex and hippocampus of l1, suggesting that tau accumulation underpins the loss of cholinergic markers in the basal forebrain and its projection targets. |
2024-04-12 |
2024-04-14 |
mouse |
| Eid Abo Hamza, Richard Tindle, Simon Pawlak, Dalia Bedewy, Ahmed A Moustaf. The impact of poverty and socioeconomic status on brain, behaviour, and development: a unified framework. Reviews in the neurosciences. 2024-04-12. PMID:38607658. |
while there are many studies on the impact of low ses on the brain (including cortex, hippocampus, amygdala, and even neurotransmitters) and behaviours (including educational attainment, language development, development of psychopathological disorders), prior studies did not integrate behavioural, educational, and neural findings in one framework. |
2024-04-12 |
2024-04-14 |
Not clear |
| Eid Abo Hamza, Richard Tindle, Simon Pawlak, Dalia Bedewy, Ahmed A Moustaf. The impact of poverty and socioeconomic status on brain, behaviour, and development: a unified framework. Reviews in the neurosciences. 2024-04-12. PMID:38607658. |
impaired functioning of the amygdala can lead to the development of psychopathological disorders, while impaired hippocampus and cortex functions are associated with a delay in learning and language development as well as poor academic performance. |
2024-04-12 |
2024-04-14 |
Not clear |
| Wenyan Zhong, Jingjing Chen, Yumin He, Li Xiao, Chengfu Yua. The polysaccharides from Balanophora polyandra enhanced neuronal autophagy to ameliorate brain function decline in natural aging mice through the PI3K/AKT/mTOR signaling pathway. Neuroreport. 2024-04-10. PMID:38597274. |
furthermore, bpp upregulated autophagy-related proteins lc3 ii/i, parkin, and pink1 in the cortex and hippocampus of aging mice, and significantly decreased the expression of p62, pi3k, p-protein kinase b (akt), and p-mtor. |
2024-04-10 |
2024-04-12 |
mouse |
| Joseph M Schrader, Feng Xu, Kevin J Agostinucci, Nicholas A DaSilva, William E Van Nostran. Longitudinal markers of cerebral amyloid angiopathy and related inflammation in rTg-DI rats. Scientific reports. vol 14. issue 1. 2024-04-10. PMID:38600214. |
longitudinal brain regional proteomic analysis revealed increased differentially expressed proteins (dep) including anxa3, htra1, apoe, cst3, and clu, shared between the cortex, hippocampus, and thalamus, at both stages of disease in rtg-di rats. |
2024-04-10 |
2024-04-13 |
rat |