| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthew P Gunn, Gregory M Rose, Alexis E Whitton, Diego A Pizzagalli, David G Gilber. Smoking Progression and Nicotine-Enhanced Reward Sensitivity Predicted by Resting-State Functional Connectivity in Salience and Executive Control Networks. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2024-04-16. PMID:38624067. |
we hypothesized that high rsfc between brain areas with high densities of nicotinic receptors (insula, anterior cingulate cortex [acc], hippocampus, thalamus) and areas involved in reward-seeking (nucleus accumbens [nacc], prefrontal cortex [pfc]) would predict nicotine-enhanced reward sensitivity and smoking progression. |
2024-04-16 |
2024-04-18 |
Not clear |
| Eliza M Greiner, Mary E Witt, Stephanie J Moran, Gorica D Petrovic. Activation patterns in male and female forebrain circuitries during food consumption under novelty. Brain structure & function. 2024-01-09. PMID:38193917. |
novel context induced fos robustly in almost every region analyzed, including the central (cea) and basolateral complex nuclei of the amygdala, the thalamic paraventricular (pvt) and reuniens nuclei, the nucleus accumbens (acb), the medial prefrontal cortex prelimbic and infralimbic areas, and the dorsal agranular insular cortex (ai). |
2024-01-09 |
2024-01-10 |
rat |
| Eliza M Greiner, Mary E Witt, Stephanie J Moran, Gorica D Petrovic. Activation patterns in male and female forebrain circuitries during food consumption under novelty. Research square. 2023-10-04. PMID:37790415. |
novel context induced fos robustly in almost every region analyzed, including the central (cea) and basolateral complex nuclei of the amygdala, the thalamic paraventricular (pvt) and reuniens nuclei, the nucleus accumbens (acb), the medial prefrontal cortex prelimbic and infralimbic areas, and the dorsal agranular insular cortex (ai). |
2023-10-04 |
2023-10-07 |
rat |
| Erika M Vitale, Adrianna Kirckof, Adam S Smit. Partner-seeking and limbic dopamine system are enhanced following social loss in male prairie voles (Microtus ochrogaster). Genes, brain, and behavior. 2023-07-31. PMID:37519035. |
furthermore, we examined dopamine (da) receptor mrna expression in the anterior insula cortex (aic), nucleus accumbens (nac), and anterior cingulate (acc), regions with higher activation in grieving humans. |
2023-07-31 |
2023-08-14 |
Not clear |
| Dylan E Kirsch, Raquel Kosted, Vanessa Le, Jorge R C Almeida, Kim Fromme, Stephen M Strakowski, Elizabeth T C Lippar. Ventral prefrontal network response to alcohol in young adults with bipolar disorder: a within-subject randomized placebo-controlled alcohol administration study. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-07-20. PMID:37474761. |
acute alcohol was associated with reduced functional connectivity between the insula - subcallosal cingulate cortex, and increased connectivity between the left nucleus accumbens - ventromedial pfc in bipolar disorder, but with no change in functional connectivity between these regions in healthy peers. |
2023-07-20 |
2023-08-14 |
human |
| Laura Santana Cordón, Domingo Afonso-Oramas, Alejandro Lemus Mesa, Miriam González-Gómez, Pedro Barroso-Chine. Morphological study of neuropeptide Y expression in human and mouse anterior insular cortex: overexpression in the insular cortex and nucleus accumbens in obese mice on a long-term obesogenic diet. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 2023-06-24. PMID:37355144. |
the anterior lobe of the insular cortex (ains) is a cortical region that has reciprocal connections with limbic centers such as the anterior cingulate cortex, prefrontal cortex, amygdala and nucleus accumbens (nac). |
2023-06-24 |
2023-08-14 |
mouse |
| William Parsons, Eliza Greiner, Laura Buczek, Jennifer Migliaccio, Erin Corbett, Amanda M K Madden, Gorica D Petrovic. Sex differences in activation of extra-hypothalamic forebrain areas during hedonic eating. Brain structure & function. 2022-10-18. PMID:36258044. |
the fos induction analysis identified sex differences in recruitment of specific areas of the medial prefrontal cortex, paraventricular nucleus of the thalamus (pvt), nucleus accumbens (acb), and central nucleus of the amygdala (cea), and similar patterns across sexes in the insular cortex. |
2022-10-18 |
2023-08-14 |
rat |
| Ryan E Tyler, Maya N Bluitt, Kalynn Van Voorhies, Laura C Ornelas, Benjamin Z S Weinberg, Joyce Beshee. Predator odor (TMT) exposure potentiates interoceptive sensitivity to alcohol and increases GABAergic gene expression in the anterior insular cortex and nucleus accumbens in male rats. Alcohol (Fayetteville, N.Y.). 2022-09-23. PMID:36150613. |
predator odor (tmt) exposure potentiates interoceptive sensitivity to alcohol and increases gabaergic gene expression in the anterior insular cortex and nucleus accumbens in male rats. |
2022-09-23 |
2023-08-14 |
rat |
| Qi Wang, Jia-Jie Zhu, Lizhao Wang, Yan-Peng Kan, Yan-Mei Liu, Yan-Jiao Wu, Xue Gu, Xin Yi, Ze-Jie Lin, Qin Wang, Jian-Fei Lu, Qin Jiang, Ying Li, Ming-Gang Liu, Nan-Jie Xu, Michael X Zhu, Lu-Yang Wang, Siyu Zhang, Wei-Guang Li, Tian-Le X. Insular cortical circuits as an executive gateway to decipher threat or extinction memory via distinct subcortical pathways. Nature communications. vol 13. issue 1. 2022-09-21. PMID:36130959. |
using an auditory fear-conditioning and extinction paradigm in male mice, here we discovered that two distinct projection neuron subpopulations in physical proximity within the insular cortex (ic), targeting the central amygdala (cea) and nucleus accumbens (nac), respectively, to encode fear and extinction memories. |
2022-09-21 |
2023-08-14 |
mouse |
| Jason Yuen, Abbas Z Kouzani, Michael Berk, Susannah J Tye, Aaron E Rusheen, Charles D Blaha, Kevin E Bennet, Kendall H Lee, Hojin Shin, Jee Hyun Kim, Yoonbae O. Deep Brain Stimulation for Addictive Disorders-Where Are We Now? Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2022-04-12. PMID:35411483. |
animal studies showed that dbs of targets such as nucleus accumbens (nac), insula, and subthalamic nucleus reduces drug use and seeking. |
2022-04-12 |
2023-08-13 |
human |
| Kensuke Hirose, Yuka Nakaya, Kohei Kitano, Yasuhiko Saito, Ryosuke Kaneko, Yuchio Yanagawa, Kiyofumi Yamamoto, Tetsuo Shirakawa, Masayuki Kobayash. Differential regulation of medium spiny and cholinergic neurons in the nucleus accumbens core by the insular and medial prefrontal cortices in the rat. Pflugers Archiv : European journal of physiology. vol 473. issue 12. 2021-11-25. PMID:34724104. |
the nucleus accumbens (nac) receives cortical projections principally from the insular cortex (ic) and medial prefrontal cortex (mpfc). |
2021-11-25 |
2023-08-13 |
rat |
| Yu Tang, Maohua Wang, Ting Zheng, Fengying Yuan, Han Yang, Fugang Han, Guangxiang Che. Grey matter volume alterations in trigeminal neuralgia: A systematic review and meta-analysis of voxel-based morphometry studies. Progress in neuro-psychopharmacology & biological psychiatry. vol 98. 2021-11-22. PMID:31756417. |
the results revealed that tn patients had gm volume abnormalities mainly in the basal ganglia, including the putamen, nucleus accumbens (nac), caudate nucleus and amygdala, as well as the cingulate cortex (cc), thalamus, insula and superior temporal gyrus (stg). |
2021-11-22 |
2023-08-13 |
Not clear |
| Lauren M Sippel, Julianne C Flanagan, Paul E Holtzheimer, Megan M Moran-Santa-Maria, Kathleen T Brady, Jane E Josep. Effects of intranasal oxytocin on threat- and reward-related functional connectivity in men and women with and without childhood abuse-related PTSD. Psychiatry research. Neuroimaging. vol 317. 2021-11-09. PMID:34455213. |
using a double-blind, randomized, placebo-controlled crossover design, we tested whether intranasal oxytocin (24 international units) influenced functional coupling of the amygdala with the anterior insula (ai), dorsal anterior cingulate cortex, and nucleus accumbens in response to implicitly presented fearful, angry, and happy faces among childhood trauma-exposed individuals with (n = 16, 9 women) and without ptsd (n = 18, 12 women). |
2021-11-09 |
2023-08-13 |
Not clear |
| Josiah K Leong, Tiffany C Ho, Natalie L Colich, Lucinda Sisk, Brian Knutson, Ian H Gotli. White-matter tract connecting anterior insula to nucleus accumbens predicts greater future motivation in adolescents. Developmental cognitive neuroscience. vol 47. 2021-10-13. PMID:33373886. |
whereas activity in the nucleus accumbens (nacc) can predict approach toward incentive gain, activity in anterior insula (ains) is associated with avoidance of incentive loss. |
2021-10-13 |
2023-08-13 |
Not clear |
| Di Qi, Charlene L M Lam, Jing Jun Wong, Dorita H F Chang, Tatia M C Le. Positive affect is inversely related to the salience and emotion network's connectivity. Brain imaging and behavior. vol 15. issue 4. 2021-09-06. PMID:33033982. |
we observed that positive affect was negatively associated with connectivity within the salience and emotion network, particularly with the bidirectional connections spanning the left anterior insula and left nucleus accumbens. |
2021-09-06 |
2023-08-13 |
Not clear |
| Joyce T Da Silva, Christina Tricou, Youping Zhang, Amir Tofighbakhsh, David A Seminowicz, Jin Y R. Pain modulatory network is influenced by sex and age in a healthy state and during osteoarthritis progression in rats. Aging cell. vol 20. issue 2. 2021-09-06. PMID:33400367. |
young females exhibited widespread pag fc in the early phase, which includes connections to insula, caudal acc, and nucleus accumbens (nac). |
2021-09-06 |
2023-08-13 |
rat |
| Xingxing Zhu, Joey Ward, Breda Cullen, Donald M Lyall, Rona J Strawbridge, Laura M Lyall, Daniel J Smit. Phenotypic and genetic associations between anhedonia and brain structure in UK Biobank. Translational psychiatry. vol 11. issue 1. 2021-08-02. PMID:34282121. |
we found that state anhedonia was significantly associated with reduced total grey matter volume (gmv); increased total white matter volume (wmv); smaller volumes in thalamus and nucleus accumbens; reduced ct within the paracentral cortex, the opercular part of inferior frontal gyrus, precentral cortex, insula and rostral anterior cingulate cortex; and poorer integrity of many white matter tracts. |
2021-08-02 |
2023-08-13 |
human |
| Ileana Morales, Kent C Berridg. 'Liking' and 'wanting' in eating and food reward: Brain mechanisms and clinical implications. Physiology & behavior. vol 227. 2021-06-21. PMID:32846152. |
hedonic hotspots are found in nucleus accumbens medial shell, ventral pallidum, orbitofrontal cortex, insula cortex, and brainstem. |
2021-06-21 |
2023-08-13 |
Not clear |
| Marlou P Lasschuijt, Kees de Graaf, Monica Mar. Effects of Oro-Sensory Exposure on Satiation and Underlying Neurophysiological Mechanisms-What Do We Know So Far? Nutrients. vol 13. issue 5. 2021-05-26. PMID:33919044. |
oro-sensory exposure to food affects satiation by direct signaling via the brainstem to higher cortical regions involved in taste and reward, including the nucleus accumbens and the insula. |
2021-05-26 |
2023-08-13 |
Not clear |
| Sarah F Dean, Samantha J Fede, Nancy Diazgranados, Reza Momena. Addiction neurocircuitry and negative affect: A role for neuroticism in understanding amygdala connectivity and alcohol use disorder. Neuroscience letters. vol 722. 2021-04-19. PMID:32045624. |
the indirect effect of neuroticism was significant for the lvms of left amygdala connectivity with the nucleus accumbens (nacc), posterior insula, and dorsal anterior cingulate cortex (dacc). |
2021-04-19 |
2023-08-13 |
human |