| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Osman Sinen, Ayşegül Gemici Sinen, Narin Derin, Mutay Aydın Asla. Nasal Application of Kisspeptin-54 Mitigates Motor Deficits by Reducing Nigrostriatal Dopamine Loss in Hemiparkinsonian Rats. Behavioural brain research. 2024-05-04. PMID:38703793. |
the levels of dopamine in the striatum were determined with mass spectrometry. |
2024-05-04 |
2024-05-07 |
rat |
| Benneth Ben-Azu, Adaeze Adebesin, Goodes E Moke, Vivian O Ojiokor, Adebayo Olusegun, Thiophilus A Jarikre, Elizabeth T Akinluyi, Opajobi A Olukemi, Noah A Omeiza, Paul Nkenchor, Avwenayeri R Niemogha, Ejaita D Ewere, Chioma Igwoku, Favour Omamogh. Alcohol exacerbates psychosocial stress-induced neuropsychiatric symptoms: attenuation by geraniol. Neurochemistry international. 2024-05-04. PMID:38703789. |
in line with this, geraniol increased the levels of dopamine, serotonin, and glutamic-acid decarboxylase enzyme, accompanied by reduced monoamine oxidase-b and acetylcholinesterase activities in the prefrontal-cortex, hippocampus, and striatum. |
2024-05-04 |
2024-05-07 |
mouse |
| Jena Delaney, Sanya Nathani, Victor Tan, Carson Chavez, Alexander Orr, Joon Paek, Mojdeh Faraji, Barry Setlow, Nikhil M Ur. Enhanced cognitive flexibility and phasic striatal dopamine dynamics in a mouse model of low striatal tonic dopamine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-05-02. PMID:38698264. |
in a probabilistic reversal learning task, net-ko mice showed enhanced reversal learning, which was consistent with larger phasic dopamine transients (dlight) in the dorsomedial striatum (dms) during reward delivery and reward omission, compared to wt controls. |
2024-05-02 |
2024-05-05 |
mouse |
| Hong Chen, Xie Wang, Ze Chang, Juan Zhang, Daojun Xi. Genetic causal relationship between multiple immune cell phenotypes and Parkinson's disease: a two sample bidirectional Mendelian randomization study. Journal of neurophysiology. 2024-05-01. PMID:38690999. |
it is currently believed that its main pathological basis is a decrease in dopamine concentration in the striatum of the brain. |
2024-05-01 |
2024-05-04 |
Not clear |
| Yilin Tang, Yuting Li, Peiyu Cao, Yingbo Dong, Guoxin Xu, Qi Si, Runda Li, Yuxiu Su. Striatum and globus pallidus structural abnormalities in schizophrenia: A retrospective study of the different stages of the disease. Progress in neuro-psychopharmacology & biological psychiatry. 2024-05-01. PMID:38692473. |
the basal ganglia are important structures for the release of dopamine in the limbic circuits of the midbrain, and the striatum and globus pallidus are the major nuclei of the basal ganglia, and the dysfunction of these regions has been the basis of many models that have attempted to explain the underlying mechanisms of schizophrenia symptoms. |
2024-05-01 |
2024-05-04 |
Not clear |
| Leonardo Sportelli, Daniel P Eisenberg, Roberta Passiatore, Enrico D'Ambrosio, Linda A Antonucci, Jasmine S Bettina, Qiang Chen, Aaron L Goldman, Michael D Gregory, Kira Griffiths, Thomas M Hyde, Joel E Kleinman, Antonio F Pardiñas, Madhur Parihar, Teresa Popolizio, Antonio Rampino, Joo Heon Shin, Mattia Veronese, William S Ulrich, Caroline F Zink, Alessandro Bertolino, Oliver D Howes, Karen F Berman, Daniel R Weinberger, Giulio Pergol. Dopamine signaling enriched striatal gene set predicts striatal dopamine synthesis and physiological activity in vivo. Nature communications. vol 15. issue 1. 2024-04-30. PMID:38688917. |
a higher polygenic risk score for schizophrenia parsed by this set of genes predicts greater dopamine synthesis in the striatum and greater striatal activation during reward anticipation. |
2024-04-30 |
2024-05-03 |
Not clear |
| Hong-Bao Li, Meng-Lu Xu, Wen-Jie Xia, Yuan-Yuan Dong, Bo Peng, Qing Su, Xiao-Min Wang, Jia-Yue Yu, Ya-Nan Gao, Jun-Zhe Wu, Meng-Yue Xu, Jin-Bao Yang, Zhi-Ming Dai, Lei Chen, Ying Li, Juan Ba. Antihypertensive treatment during pregnancy induces long-term changes in gut microbiota and the behaviors of the attention deficit hyperactivity disorder offspring. Toxicology and applied pharmacology. 2024-04-28. PMID:38679241. |
lc-ms/ms and immunohistochemistry assays suggested elevated expression of brain derived neurotrophic factor (bdnf) and dopamine in the prefrontal cortex and striatum of offspring exposed to captopril/ labetalol, which may account for the improvement of the offspring's psychiatric functions. |
2024-04-28 |
2024-05-01 |
rat |
| Asier Aristieta, John E Parker, Ya Emma Gao, Jonathan E Rubin, Aryn H Gitti. Dopamine depletion weakens direct pathway modulation of SNr neurons. Neurobiology of disease. 2024-04-26. PMID:38670278. |
chronic loss of dopamine, as occurs in parkinson's disease, disrupts the balance of direct and indirect pathway neurons at the level of the striatum, but the question of how dopamine loss affects information propagation along these pathways outside of the striatum is less well understood. |
2024-04-26 |
2024-04-29 |
Not clear |
| Andrew Mah, Carla Golden, Christine Constantinopl. Mesolimbic dopamine encodes reward prediction errors independent of learning rates. bioRxiv : the preprint server for biology. 2024-04-25. PMID:38659861. |
these values are thought to be represented in synaptic weights in the striatum, and updated by dopamine-dependent plasticity, suggesting that dopamine release might reflect the product of the learning rate and rpe. |
2024-04-25 |
2024-04-28 |
rat |
| Tristan Hynes, Maxime Fouyssac, Mickaël Puaud, Dhaval Joshi, Chloe Chernoff, Sonja Stiebahl, Lola Michaud, David Beli. Pan-striatal reduction in the expression of the astrocytic dopamine transporter precedes the development of dorsolateral striatum dopamine-dependent incentive heroin seeking habits. The European journal of neuroscience. 2024-04-23. PMID:38650303. |
pan-striatal reduction in the expression of the astrocytic dopamine transporter precedes the development of dorsolateral striatum dopamine-dependent incentive heroin seeking habits. |
2024-04-23 |
2024-04-26 |
rat |
| Tristan Hynes, Maxime Fouyssac, Mickaël Puaud, Dhaval Joshi, Chloe Chernoff, Sonja Stiebahl, Lola Michaud, David Beli. Pan-striatal reduction in the expression of the astrocytic dopamine transporter precedes the development of dorsolateral striatum dopamine-dependent incentive heroin seeking habits. The European journal of neuroscience. 2024-04-23. PMID:38650303. |
the striatum is tiled by a syncytium of astrocytes that express the dopamine transporter (dat), the level of which is altered in individuals with heroin use disorder. |
2024-04-23 |
2024-04-26 |
rat |
| Hao Yang, XiaoLi Yang, SiLu Ya. A dynamic computational model of the parallel circuit on the basal ganglia-cortex associated with Parkinson's disease dementia. Biological cybernetics. 2024-04-21. PMID:38644417. |
more importantly, the spatiotemporal course of dopamine depletion in parkinson's disease patients is well simulated, which states that with the loss of dopaminergic neurons projecting to the striatum, motor dysfunction of parkinson's disease is first observed, whereas cognitive impairment occurs after a period of onset of motor dysfunction. |
2024-04-21 |
2024-04-24 |
Not clear |
| Cian-Fen Jhuo, Chun-Jung Chen, Jason T C Tzen, Wen-Ying Che. Teaghrelin protected dopaminergic neurons in MPTP-induced Parkinson's disease animal model by promoting PINK1/Parkin-mediated mitophagy and AMPK/SIRT1/PGC1-α-mediated mitochondrial biogenesis. Environmental toxicology. 2024-04-16. PMID:38622810. |
tyrosine hydroxylase and dopamine transporter protein were found reduced in the striatum and midbrain of mptp-treated mice, and significantly mitigated by teaghrelin supplementation. |
2024-04-16 |
2024-04-18 |
mouse |
| Cian-Fen Jhuo, Chun-Jung Chen, Jason T C Tzen, Wen-Ying Che. Teaghrelin protected dopaminergic neurons in MPTP-induced Parkinson's disease animal model by promoting PINK1/Parkin-mediated mitophagy and AMPK/SIRT1/PGC1-α-mediated mitochondrial biogenesis. Environmental toxicology. 2024-04-16. PMID:38622810. |
tyrosine hydroxylase and dopamine transporter protein were found reduced in the striatum and midbrain of mptp-treated mice, and significantly mitigated by teaghrelin supplementation. |
2024-04-16 |
2024-04-18 |
mouse |
| Koichi Tanaka, Mohammed E Choudhury, Satoshi Kikuchi, Ikuko Takeda, Kensuke Umakoshi, Noriyuki Miyaue, Kanta Mikami, Ayane Takenaga, Harumichi Yagi, Rintaro Shinabe, Hironori Matsumoto, Hajime Yano, Masahiro Nagai, Jun Takeba, Junya Tanak. A dopamine D1-like receptor-specific agonist improves the survival of septic mice. iScience. vol 27. issue 4. 2024-04-16. PMID:38623339. |
methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride reduced dopamine levels in the striatum and increased mortality in septic mice. |
2024-04-16 |
2024-04-18 |
mouse |
| Xiaomei Wu, Renxiang Yuan, Yichong Xu, Kai Wang, Hong Yuan, Tingting Meng, Fuqiang H. Functionalized lipid nanoparticles modulate the blood-brain barrier and eliminate α-synuclein to repair dopamine neurons. Asian journal of pharmaceutical sciences. vol 19. issue 2. 2024-04-11. PMID:38601010. |
motor symptoms of mice in lpc-bosa/cso-exe group are significantly improved, and the content of dopamine is 1.85 times (substantia nigra compacta) and 1.49 times (striatum) that of pd mice. |
2024-04-11 |
2024-04-13 |
mouse |
| Xin Yi Ng, Mian Ca. Dysfunction of synaptic endocytic trafficking in Parkinson's disease. Neural regeneration research. vol 19. issue 12. 2024-04-10. PMID:38595283. |
parkinson's disease is characterized by the selective degeneration of dopamine neurons in the nigrostriatal pathway and dopamine deficiency in the striatum. |
2024-04-10 |
2024-04-12 |
mouse |
| Liv Engel, Amy R Wolff, Madelyn Blake, Val L Collins, Sonal Sinha, Benjamin T Saunder. Dopamine neurons drive spatiotemporally heterogeneous striatal dopamine signals during learning. bioRxiv : the preprint server for biology. 2024-04-08. PMID:38585717. |
we used a fluorescent dopamine biosensor to monitor dopamine in the nucleus accumbens (nac) core and shell, dorsomedial striatum (dms), and dorsolateral striatum (dls). |
2024-04-08 |
2024-04-10 |
Not clear |
| Liv Engel, Amy R Wolff, Madelyn Blake, Val L Collins, Sonal Sinha, Benjamin T Saunder. Dopamine neurons drive spatiotemporally heterogeneous striatal dopamine signals during learning. bioRxiv : the preprint server for biology. 2024-04-08. PMID:38585717. |
together, our studies show broad dissociation in the fundamental prediction and reward-related information generated by different dopamine neuron populations and signaled by dopamine across the striatum. |
2024-04-08 |
2024-04-10 |
Not clear |
| Cesar C Ceballos, Lei Ma, Maozhen Qin, Haining Zhon. Prevalent co-release of glutamate and GABA throughout the mouse brain. bioRxiv : the preprint server for biology. 2024-04-08. PMID:38585864. |
although dopaminergic axons release both glutamate and gaba in the striatum, deletion of dopamine neurons did not eliminate biphasic minis, indicating that the co-release originates from another neuronal type. |
2024-04-08 |
2024-04-10 |
mouse |