| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sheng Li, Yanbing Liu, Sen Lu, Jiayi Xu, Xiaokun Liu, Di Yang, Yuxuan Yang, Lin Hou, Ning L. A crazy trio in Parkinson's disease: metabolism alteration, α-synuclein aggregation, and oxidative stress. Molecular and cellular biochemistry. 2024-04-16. PMID:38625515. |
parkinson's disease (pd) is an aging-associated neurodegenerative disorder, characterized by the progressive loss of dopaminergic neurons in the pars compacta of the substantia nigra and the presence of lewy bodies containing α-synuclein within these neurons. |
2024-04-16 |
2024-04-18 |
Not clear |
| Erind Alushaj, Nicholas Handfield-Jones, Alan Kuurstra, Anisa Morava, Ravi S Menon, Adrian M Owen, Manas Sharma, Ali R Khan, Penny A MacDonal. Increased iron in the substantia nigra pars compacta identifies patients with early Parkinson'sdisease: A 3T and 7T MRI study. NeuroImage. Clinical. vol 41. 2024-02-20. PMID:38377722. |
degeneration in the substantia nigra (sn) pars compacta (snc) underlies motor symptoms in parkinson's disease (pd). |
2024-02-20 |
2024-02-23 |
Not clear |
| Ramesha Hanumanthappa, Deepa Mugudthi Venugopal, Nethravathi P C, Ahesanulla Shaikh, Siddaiah B M, Geetha B Heggannavar, Akshay A Patil, Hemalatha Nanjaiah, D Suresh, Mahadevappa Y Kariduraganavar, Shamprasad Varija Raghu, Kuramkote Shivanna Devaraj. Polyvinylpyrrolidone-Capped Copper Oxide Nanoparticles-Anchored Pramipexole Attenuates the Rotenone-Induced Phenotypes in a ACS omega. vol 8. issue 50. 2023-12-25. PMID:38144104. |
the disease is characterized by the loss of dopaminergic neurons in the substantia nigra, pars compacta of the midbrain. |
2023-12-25 |
2023-12-27 |
Not clear |
| Nianping Zhang, Zhaoli Yan, Hua Xin, Shuai Shao, Song Xue, Raymond Cespuglio, Shijun Wan. Relationship among α‑synuclein, aging and inflammation in Parkinson's disease (Review). Experimental and therapeutic medicine. vol 27. issue 1. 2023-12-21. PMID:38125364. |
the main pathological characteristics of pd are the selective death of dopaminergic (da) neurons in the pars compacta of the substantia nigra and the presence of lewy bodies containing α-synuclein (α-syn) within these neurons. |
2023-12-21 |
2023-12-23 |
Not clear |
| Priyanshu Sharma, Payal Mitta. Paraquat (herbicide) as a cause of Parkinson's Disease. Parkinsonism & related disorders. 2023-11-26. PMID:38008593. |
the pathogenic causes of parkinsonism include lewy bodies, intracellular protein clumps of αsynuclein, and the degeneration of dopaminergic neurons in the substantia nigra's pars compacta region. |
2023-11-26 |
2023-11-28 |
Not clear |
| Jie Zhang, Jia Li, Cheng-Xi Liu, Huan Gui, Cheng-Dong Yuan, Yi Zhan. The role of intracerebral dopamine D1 and D2 receptors in sleep-wake cycles and general anesthesia. Ibrain. vol 8. issue 1. 2023-10-03. PMID:37786416. |
dopamine (da), a monoamine neurotransmitter, is synthesized and released mainly by neurons in the ventral tegmental area and the substantia nigra (sn) pars compacta of the midbrain. |
2023-10-03 |
2023-10-07 |
Not clear |
| Francesco Cavallieri, Rubens G Cury, Thiago Guimarães, Valentina Fioravanti, Sara Grisanti, Jessica Rossi, Edoardo Monfrini, Marialuisa Zedde, Alessio Di Fonzo, Franco Valzania, Elena Mor. Recent Advances in the Treatment of Genetic Forms of Parkinson's Disease: Hype or Hope? Cells. vol 12. issue 5. 2023-03-11. PMID:36899899. |
its pathology is characterized by a prominent early death of dopaminergic neurons in the pars compacta of the substantia nigra and the presence of lewy bodies with aggregated α-synuclein. |
2023-03-11 |
2023-08-14 |
Not clear |
| Tushar Kamath, Evan Z Macosk. Insights into Neurodegeneration in Parkinson's Disease from Single-Cell and Spatial Genomics. Movement disorders : official journal of the Movement Disorder Society. 2023-03-07. PMID:36881930. |
parkinson's disease (pd) is pathologically defined by the death of dopaminergic (da) neurons within the pars compacta of the substantia nigra. |
2023-03-07 |
2023-08-14 |
Not clear |
| Wei Liang, Lulu Yao, Jiahao Chen, Zhiying Chen, Xiling Wu, Xiaobo Huan. Therapeutic and Neuroprotective Effects of Bushen Jianpi Decoction on a Rotenone-Induced Rat Model of Parkinson's Disease. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-11-28. PMID:36437828. |
parkinson's disease (pd) is an age-related neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra (sn) pars compacta. |
2022-11-28 |
2023-08-14 |
rat |
| Dongling Zhang, Junye Yao, Junyan Sun, Qiqi Tong, Silei Zhu, Junling Wang, Lili Chen, Jinghong Ma, Hongjian He, Tao W. Quantitative Susceptibility Mapping and Free Water Imaging of Substantia Nigra in Parkinson's Disease. Journal of Parkinson's disease. 2022-11-21. PMID:36404557. |
the utility of imaging methods to detect iron content in the substantia nigra pars compacta (snc) and free water imaging in the posterior substantia nigra (psn) has the potential to be imaging markers for the detection of parkinson's disease (pd). |
2022-11-21 |
2023-08-14 |
Not clear |
| Sage S Frehner, Kip T Dooley, Michelle C Palumbo, Aaron L Smith, Mark M Goodman, Karen L Bales, Sara M Freema. Effect of sex and autism spectrum disorder on oxytocin receptor binding and mRNA expression in the dopaminergic pars compacta of the human substantia nigra. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 377. issue 1858. 2022-07-20. PMID:35858098. |
effect of sex and autism spectrum disorder on oxytocin receptor binding and mrna expression in the dopaminergic pars compacta of the human substantia nigra. |
2022-07-20 |
2023-08-14 |
human |
| Maximilian Wulf, Katalin Barkovits, Karin Schork, Martin Eisenacher, Peter Riederer, Manfred Gerlach, Britta Eggers, Katrin Marcu. Neuromelanin granules of the substantia nigra: proteomic profile provides links to tyrosine hydroxylase, stress granules and lysosomes. Journal of neural transmission (Vienna, Austria : 1996). 2022-07-19. PMID:35852604. |
neuromelanin is a black-brownish pigment, present in so-called neuromelanin granules (nmgs) in the cell bodies of dopaminergic neurons in the substantia nigra (sn) pars compacta. |
2022-07-19 |
2023-08-14 |
Not clear |
| Samir Kumar Beura, Abhishek Ramachandra Panigrahi, Pooja Yadav, Sunil Kumar Sing. Role of Platelet in Parkinson's Disease: Insights into Pathophysiology & Theranostic Solutions. Ageing research reviews. 2022-07-07. PMID:35798236. |
gradual death and progressive loss of dopaminergic neurons in the pars compacta region of substantia nigra results in striatal dopamine deficiency in pd. |
2022-07-07 |
2023-08-14 |
Not clear |
| Richard M Kostrzew. Neonatal 6-hydroxydopamine lesioning of rats and dopaminergic neurotoxicity: proposed animal model of Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). 2022-03-13. PMID:35279767. |
when given to rats, neonatal 6-ohda (n6-ohda) crosses the blood-brain barrier to destroy 90-99% of dopaminergic nerves in pars compacta substantia nigra (snpc). |
2022-03-13 |
2023-08-13 |
human |
| Zhijia Jin, Ying Wang, Mojtaba Jokar, Yan Li, Zenghui Cheng, Yu Liu, Rongbiao Tang, Xiaofeng Shi, Youmin Zhang, Jihua Min, Fangtao Liu, Naying He, Fuhua Yan, Ewart Mark Haack. Automatic detection of neuromelanin and iron in the midbrain nuclei using a magnetic resonance imaging-based brain template. Human brain mapping. 2022-01-24. PMID:35072301. |
parkinson disease (pd) is a chronic progressive neurodegenerative disorder characterized pathologically by early loss of neuromelanin (nm) in the substantia nigra pars compacta (snpc) and increased iron deposition in the substantia nigra (sn). |
2022-01-24 |
2023-08-13 |
human |
| Jing Zhang, Bohao Sun, Jifeng Yang, Zhuo Chen, Zhengzheng Li, Nan Zhang, Hongzhi Li, Luxi She. Comparison of the effect of rotenone and 1‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine on inducing chronic Parkinson's disease in mouse models. Molecular medicine reports. vol 25. issue 3. 2022-01-18. PMID:35039876. |
in the mptp group, the loss of dopaminergic (da) neurons in the substantia nigra (sn) pars compacta, the reduction of the tyrosine hydroxylase content in the sn and striatum and the astrocyte proliferation and microglial activation in the sn were more significant compared with the rotenone group. |
2022-01-18 |
2023-08-13 |
mouse |
| Niels Bergsland, Laura Pelizzari, Maria Marcella Laganá, Sonia Di Tella, Federica Rossetto, Raffaello Nemni, Mario Clerici, Francesca Bagli. Automated Assessment of the Substantia Nigra Pars Compacta in Parkinson's Disease: A Diffusion Tensor Imaging Study. Journal of personalized medicine. vol 11. issue 11. 2021-11-30. PMID:34834587. |
the substantia nigra (sn) pars compacta (snpc) and pars reticulata (snpr) are differentially affected in parkinson's disease (pd). |
2021-11-30 |
2023-08-13 |
Not clear |
| Inka Brockhausen, John Schutzbach, Jiabei Wang, Beth Fishwick, Jennifer Brockhause. Glycoconjugate journal special issue on: the glycobiology of Parkinson's disease. Glycoconjugate journal. 2021-11-10. PMID:34757539. |
this condition is characterized by the degeneration of dopaminergic neurons in the pars compacta region of the substantia nigra (snpc) and by aggregation of proteins, commonly α-synuclein (snca). |
2021-11-10 |
2023-08-13 |
Not clear |
| Fatema Currim, Jyoti Singh, Anjali Shinde, Dhruv Gohel, Milton Roy, Kritarth Singh, Shatakshi Shukla, Minal Mane, Hitesh Vasiyani, Rajesh Sing. Exosome Release Is Modulated by the Mitochondrial-Lysosomal Crosstalk in Parkinson's Disease Stress Conditions. Molecular neurobiology. vol 58. issue 4. 2021-10-27. PMID:33404982. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn) pars compacta region of the brain. |
2021-10-27 |
2023-08-13 |
Not clear |
| Dmitrii E Korzhevskii, Olga V Kirik, Valeriia V Guselnikova, Darya L Tsyba, Elena A Fedorova, Igor P Grigore. Changes in cytoplasmic and extracellular neuromelanin in human substantia nigra with normal aging. European journal of histochemistry : EJH. vol 65. issue s1. 2021-09-23. PMID:34468106. |
it is present in various areas of the human brain, most often in the substantia nigra (sn) pars compacta and the locus coeruleus, the main centers of dopaminergic and noradrenergic innervation, respectively. |
2021-09-23 |
2023-08-13 |
human |